Chronic postoperative pain induces contextual fear extinction dysfunction through hippocampal NMDAR/BDNF/TrkB signaling pathway in mice [0.03%]
慢性术后疼痛通过小鼠海马NMDAR/BDNF/TrkB信号通路诱导情境恐惧消退障碍
Jiawei Zhang,Xiaoting Zheng,Gaoyan Zhang et al.
Jiawei Zhang et al.
Post-traumatic stress disorder (PTSD) is a common disorder in clinical practice, characterized by various manifestations, with fear extinction dysfunction being a typical one. Postoperative persistent pain, a form of chronic pain following ...
The molecular mechanisms through which psilocybin prevents suicide: evidence from network pharmacology and molecular docking analyses [0.03%]
网络药理学和分子对接分析证明裸盖菇素的抑止自杀分子机制研究
Ying Zhang,Lei Yang,Qiuyu Zhang et al.
Ying Zhang et al.
Psilocybin is among the most extensively studied psychedelics, with previous research suggesting its potential therapeutic role in suicide prevention. However, the precise mechanisms through which psilocybin may aid in suicide prevention re...
Evaluation of behavioural and neurochemical effects of psilocybin in mice subjected to chronic unpredictable mild stress [0.03%]
评估慢性轻度不可预测应激小鼠体内裸盖菇素的行为学和神经化学效应
Ines Erkizia-Santamaría,Igor Horrillo,Nerea Martínez-Álvarez et al.
Ines Erkizia-Santamaría et al.
Depression and anxiety are disabling and high incidence mental disorders characterized by phenotypic heterogeneity. Currently available treatments show severe limitations. Thus, there is an urgent need for effective treatments in this popul...
Multilevel brain functional connectivity and task-based representations explaining heterogeneity in major depressive disorder [0.03%]
用于解释抑郁症功能异质性的多层次脑功能连接和任务相关表征
Qi Liu,Xinqi Zhou,Chunmei Lan et al.
Qi Liu et al.
Major depressive disorder (MDD) is a devastating mental disorder characterized by considerable clinical and biological heterogeneity. While comparable clinical symptoms may represent a common pathological endpoint, it is conceivable that di...
Synergistic behavioral and neuroplastic effects of psilocybin-NMDAR modulator administration [0.03%]
裸露素和NMDAR调节剂联合给药的协同行为和神经可塑性效应
Tom Ben-Tal,Ilana Pogodin,Alexander Botvinnik et al.
Tom Ben-Tal et al.
The full therapeutic potential of serotonergic psychedelics (SP) in treating neuropsychiatric disorders, such as depression and schizophrenia, is limited by possible adverse effects, including perceptual disturbances and psychosis, which re...
CBT treatment delivery formats for generalized anxiety disorder: a systematic review and network meta-analysis of randomized controlled trials [0.03%]
认知行为疗法在通用焦虑症治疗中的交付方式：系统回顾和随机对照试验网络meta分析
Shiyu Liu,Hongqi Xiao,Yingxu Duan et al.
Shiyu Liu et al.
Objectives: To assess the comparative efficacy and acceptability of different delivery formats of cognitive behavior therapy (CBT) in treating generalized anxiety disorder (GAD). ...
Concentration-dependent effect of delta-9-tetrahydrocannabinol on epigenetic DNA modifiers in human peripheral blood mononuclear cells [0.03%]
Δ-9四氢大麻酚对人外周血单个核细胞表观遗传DNA修饰酶的影响具有浓度依赖性效应
Kerda Pulk,Kelli Somelar-Duracz,Mikk Rooden et al.
Kerda Pulk et al.
Cannabis is among the most used illicit substances in the world, and approximately 10% of regular cannabis users are estimated to be susceptible to developing cannabis use disorder (CUD). We examined the effect of different concentrations o...
A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing [0.03%]
一项关于血清素系统与情绪处理相互作用的大型多模态研究
Manfred Klöbl,Matej Murgaš,Murray Bruce Reed et al.
Manfred Klöbl et al.
Considering the complexity of serotonergic influence on emotions, we conducted a comprehensive investigation of the interplay between emotion processing and the serotonergic system using simultaneous functional and molecular neuroimaging du...
Randomized Controlled Trial
Translational psychiatry. 2025 Jun 11;15(1):196. DOI:10.1038/s41398-025-03407-2 2025
Exploring individual differences in fear extinction in male and female mice: insights from HPA axis, microbiota, and transcriptomics [0.03%]
从HPA轴、微生物群和转录组学探讨雄性和雌性小鼠恐惧消退的个体差异：洞察
Marc Ten-Blanco,María Ponce-Renilla,Inmaculada Pereda-Pérez et al.
Marc Ten-Blanco et al.
Exposure to traumatic life events may compromise physical and mental health of specific subjects. While some individuals extinguish fear appropriately, others exhibit an inefficient and persistent fear response, with remarkable differences ...
Revealing differential psychotic symptoms in schizophrenia and bipolar I disorder by manifold learning and network analyses [0.03%]
利用流形学习和网络分析揭示精神分裂症和I型躁郁症的差异性精神病理症状
Young Hoon Kim,Jinhyeok Jang,Nuree Kang et al.
Young Hoon Kim et al.
The field of psychiatry has encountered ongoing challenges in understanding the intricate nature of psychotic symptoms, particularly when they manifest in individuals diagnosed with bipolar disorder or schizophrenia. In this study, we emplo...