Postmortem brain single-nucleus and bulk gene expression analyses identify shared and distinct abnormalities in bipolar disorder and major depressive disorder [0.03%]
死后单核和批量基因表达分析识别双相情感障碍和重大抑郁障碍的相同及不同异常现象
Rongwei Gao,Ikuo Otsuka,Toshiyuki Shirai et al.
Rongwei Gao et al.
Bipolar disorder (BD) and major depressive disorder (MDD) are severe and chronic mood disorders which impairs the psychosocial functioning of patients. Besides manic or hypomanic episodes, many patients with BD also experience depressive ep...
Associations of stable psychological traits with multi-omic subtypes of Alzheimer's dementia [0.03%]
稳定的心理特征与阿尔茨海默病多组学亚型的关联研究
Andrea R Zammit,Lei Yu,Victoria N Poole et al.
Andrea R Zammit et al.
Psychological traits reflecting neuroticism, depressive symptoms, loneliness, and purpose in life are risk factors of AD dementia; however, the underlying biological mechanisms remain largely unknown. Using multi-omic data from the dorsolat...
Hydrogen sulfide mitigates spatial learning deficits in angiotensin II-Induced hypertension via inhibition of endothelial NOX2 and neuroinflammation [0.03%]
硫化氢通过抑制内皮NOX2和神经炎症缓解血管紧张素Ⅱ诱导的高血压小鼠空间学习能力下降
Gaurav Kumar,Shalini Mishra,Shyamal Goswami et al.
Gaurav Kumar et al.
Hypertension (HTN), when prolonged, extends beyond the cardiovascular system, impairs neurovascular function, and progresses into cognitive impairment. Thus, it is essential to understand the mechanism that drives HTN-induced brain pathogen...
Impact of NRSN2 deficiency on memory: Altered excitatory synaptic plasticity associated with reduced expression of NMDA receptor subunits and impaired LTP in the hippocampus [0.03%]
NRSN2缺乏对记忆的影响：与NMDA受体亚基表达降低和海马区长时程增强受损相关的兴奋性突触可塑性改变
Jialu Wei,Yongkang Wu,Yuan Yi et al.
Jialu Wei et al.
Our earlier human studies identified NRSN2 (Neurensin-2), a neuronal-specific vesicular protein, as a candidate gene contributing to 20p13 microdeletion syndrome, yet the functional consequences of NRSN2 deficiency in the nervous system rem...
Rethinking EEG biomarkers of brain disorders: a transdiagnostic dimensional view [0.03%]
从跨诊断维度视角重新思考脑疾病EEG生物标志物
Paul Theo Zebhauser,Henrik Heitmann,Peter Henningsen et al.
Paul Theo Zebhauser et al.
Developing clinically useful brain-based biomarkers remains a central challenge in translational psychiatry and neurology. Traditional approaches focusing on disorder-specific signals have shown limited clinical utility. EEG, a scalable and...
Vagus nerve-dependent antidepressant effects of ineupatorolide B via gut microbiota modulation in a mouse model of depression [0.03%]
迷走神经介导的恩郁定B通过调节肠道菌群在抑郁小鼠模型中的抗抑郁作用
Siming Wang,Yuqian Zhang,Ningning Wu et al.
Siming Wang et al.
Ineupatorolide B (InB), a sesquiterpene lactone with anti-inflammatory and anti-tumor properties, has not previously been evaluated for antidepressant effects. Given the central role of the gut-brain axis in stress-related mood disorders, w...
Mapping behavioural mechanisms linking childhood maltreatment, cognition, impulsivity, and suicidality in bipolar disorder: A network approach [0.03%]
采用网络方法研究童年虐待通过行为机制与双相障碍患者认知、冲动性和自杀性之间的关联
Natalia E Fares-Otero,Astrid E Iversen,Alfonso Gutiérrez-Zotes et al.
Natalia E Fares-Otero et al.
Childhood maltreatment (CM) has been consistently associated with increased risk and poorer outcomes in bipolar disorder (BD). However, the behavioural and cognitive mechanisms linking CM and suicidality remain poorly understood, limiting t...
A systematic narrative review of the form, process, and function of sensory hyposensitivity in depression [0.03%]
系统性叙述审查抑郁症感觉 hypo敏感性的形式、过程和功能
Christopher F Sharpley,G Lorenzo Odierna,Vicki Bitsika et al.
Christopher F Sharpley et al.
As well as the key diagnostic symptoms that define Major Depressive Disorder (MDD), there is also evidence that some aspects of sensory sensitivity may decrease concurrently with MDD. However, although various individual studies have report...
Blood IL-6 is a critical trigger of depressive symptoms in a mouse model for human atopic dermatitis [0.03%]
血清中IL-6是小鼠人类特应性皮炎模型中诱发抑郁症状的关键因素
Kenshiro Matsuda,Ryo Muko,Changjong Moon et al.
Kenshiro Matsuda et al.
Patients with atopic dermatitis (AD) often suffer from mental health issues such as depression. Crosstalk between proinflammatory cytokines and hippocampal circuits may be a potent risk factor for behavioral abnormalities in depression, inc...
Prenatal tobacco exposure and adult offspring brain health: the mediating role of leukocyte telomere length in a large population-based cohort [0.03%]
孕期烟草暴露与后代大脑健康：基于大量人群的队列研究中关于白细胞端粒长度介导作用的影响
Zirui Wang,Xingyu Zhang,Xianglu Meng et al.
Zirui Wang et al.
Maternal smoking during pregnancy (MSDP) has been linked to adverse effects on offspring brain health. However, the underlying mechanisms remain unclear. Given that offspring exposed to MSDP exhibit shortened leukocyte telomere length (LTL)...