Aberrant insula activity to negative and reduced learning from positive feedback underlie maladaptive self-beliefs in depression [0.03%]
抑郁症患者杏仁核活动异常以及从正向反馈中习得能力下降导致适应性较差的自我信念
Nora Czekalla,Alexander Schröder,Annalina V Mayer et al.
Nora Czekalla et al.
Background: Maladaptive self-beliefs are a core symptom of major depressive disorder. These beliefs are perpetuated by a negatively biased integration of self-related feedback. Understanding the neurocomputational mechani...
Cardiac vagal activity during in-vivo threat exposure is associated with within-session inhibition of fear and avoidance [0.03%]
在体威胁暴露期间的心脏迷走神经活动与恐惧和回避的消退有关
Christoph Szeska,Kai Klepzig,Alfons O Hamm et al.
Christoph Szeska et al.
Laboratory research suggests that the attenuation of defensive responses during threat exposure relies on the inhibition of subcortical defense circuits orchestrated by the prefrontal cortex. This process may be reflected by increased vagal...
Frequency of therapeutic drug monitoring in inpatient precision depression care and duration of hospitalization [0.03%]
精准住院制抑郁症治疗中药物治疗监测频率与住院时间的关系
Chantal Hampf,Jürgen Deckert,Sebastian Walther et al.
Chantal Hampf et al.
In psychiatry, therapeutic drug monitoring (TDM) is routinely used to improve treatment safety and efficacy, yet its association with hospitalization duration and cost-effectiveness remains unclear. We hypothesized that the frequency of rou...
Disrupted hierarchical functional brain organization in affective and psychotic disorders: insights from functional brain gradients [0.03%]
情感和精神分裂症障碍中紊乱的功能性大脑组织：来自功能性脑梯度的启示
Hannah Hacker,Linnea Hoheisel,Madalina-Octavia Buciuman et al.
Hannah Hacker et al.
Individuals with psychosis and depression show widespread alterations in brain resting-state functional connectivity (rs-FC), affecting both sensory and higher-order brain regions. In this study, we investigate disruptions in the hierarchic...
Early life adversity shapes neural and behavioural responses to oxytocin during altruistic decision-making [0.03%]
早期逆境会塑造亲社会决策过程中催产素的神经和行为效应
Nina Marsh,Vanessa Jeske,Mari Babasiz et al.
Nina Marsh et al.
What makes some people willing to help strangers at a personal cost, while others are more hesitant or selective? Early life adversity - such as neglect or abuse - may shape how we respond to strangers in need later in life, yet the underly...
Tactile stimulus discrimination in adolescents with anorexia nervosa: a behavioral and neurophysiological study [0.03%]
青少年神经性厌食症患者的触觉刺激辨别能力的行为学和神经生理学研究
Jule Romea Lammers,Hugo Romero Frausto,Anke Dalhoff et al.
Jule Romea Lammers et al.
Body image disturbance (BID) is a key symptom of anorexia nervosa (AN) and involves body size overestimation. Although this overestimation might be related to perceptual deficits, little is known about tactile perception in AN. To clarify t...
Cell deformability of peripheral blood mononuclear cells is reduced in individuals with major depressive disorder [0.03%]
抑郁症患者外周血单个核细胞的变形能力下降
Lisa Kwapich,Tobias Neckernuss,Daniel Geiger et al.
Lisa Kwapich et al.
Major depressive disorder (MDD) is a complex mental disorder with a pathophysiology that remains only partly understood and involves, among other factors, alterations in immune system function. One of the main risk factors for mental disord...
Single-cell long- and short-read transcriptomics sheds light on high-altitude adaptation in the porcine cerebral cortex [0.03%]
单细胞长读段和短读段转录组揭示了猪大脑皮层的高原适应性
Yongcheng Chang,Bofang Duan,Hailong Huo et al.
Yongcheng Chang et al.
The cerebral cortex is highly sensitive to oxygen availability and thus serves as an ideal model for studying neural adaptation to hypoxia. Here, we integrated long-read (Oxford Nanopore) and short-read (Illumina) single-cell RNA sequencing...
Understanding neuroinflammation in post-COVID-19 syndrome: biological mechanisms, diagnostic biomarkers, and therapeutic prospects [0.03%]
理解新冠后遗症的神经炎症：生物机制、诊断生物标志物和治疗前景
Daniel Martins,Danielle Beckman,Marco Loggia et al.
Daniel Martins et al.
Post-COVID-19 syndrome (PCS) is an escalating global health concern, marked by persistent cognitive, neurological, and psychiatric symptoms following acute SARS-CoV-2 infection. Although its underlying mechanisms remain incompletely underst...
Temporal interference stimulation: A new paradigm for non-invasive deep brain stimulation-mechanistic insights, clinical advances, and future directions [0.03%]
时间干扰刺激：非侵入性深部脑刺激的新范式-机制见解，临床进展和未来方向
Wenjiang Wang,Missey Florian,Chenxi Ling et al.
Wenjiang Wang et al.
Neurological and psychiatric disorders frequently arise from dysfunctional deep-brain circuits, yet targeting these subcortical structures with conventional non-invasive neuromodulation remains a significant challenge due to the lack of foc...