Identification of susceptibility modules and genes through WGCNA and ceRNA network analysis in neuropathic pain-induced anxiodepression [0.03%]
Yongtao He,Yaowei Xu,Fei Xing et al.
Yongtao He et al.
Neuropathic pain (NP) is frequently comorbid with anxiety and depression, yet the underlying molecular mechanisms in the brain remain poorly understood, hindering the development of targeted therapies. This study aimed to identify key trans...
Augmenting extinction with counterconditioning strengthens and sustains neural safety representations in PTSD [0.03%]
Samuel E Cooper,Nicole E Keller,Elizabeth A Bauer et al.
Samuel E Cooper et al.
Because extinction forms the empirical foundation of exposure therapy, strategies to enhance extinction could lead to more effective interventions for posttraumatic stress disorder (PTSD). Here, we used functional MRI to compare immediate a...
Concurrent maternal stress and THC exposure alters maternal regulation and downstream adolescent corticolimbic programs [0.03%]
Jimmy Olusakin,Mahima Dewan,Atul Kashyap et al.
Jimmy Olusakin et al.
Cannabis use during pregnancy is increasing, often to alleviate stress and anxiety, yet the impact of prenatal cannabis exposure alone, or in combination with psychosocial stress on maternal regulation and downstream offspring neurodevelopm...
Paving the way for precision treatment of psychiatric symptoms with functional connectivity neurofeedback [0.03%]
J E Taylor,T Oka,M Murakami et al.
J E Taylor et al.
Treatment for Major Depressive Disorder (MDD) remains relatively homogeneous, despite patients having heterogeneous subsets of symptoms with differing underlying neural aberrations. Demonstrating potential for a more individualised treatmen...
Jack Keady,Richard Charnigo,Jakob D Shaykin et al.
Jack Keady et al.
The "loss of control" over drug consumption, known as escalation of intake in opioid use disorder (OUD), is well-established in preclinical rodent models. However, little is known about how antecedent behavioral characteristics, such as val...
Establishment and validation of an Alzheimer's disease diagnostic model on the basis of exhaled volatile organic compound characteristics [0.03%]
Peng Liu,Yanwei Xu,Ping Che et al.
Peng Liu et al.
Exhaled volatile organic compounds (VOCs) have been investigated in some diseases, including cognitive impairment, in pilot studies. The present study aimed to explore the role of exhaled VOCs in identifying and differentiating patients wit...
A case-series of oral acetate supplementation for gut microbiota alteration and metabolic improvement in patients with affective disorders on psychotropics [0.03%]
Kait F Al,Michael Wammes,Michael Warren et al.
Kait F Al et al.
Mental illnesses affect one in five Canadians and often require psychotropic medications. While effective, many psychotropic medications can cause weight gain and metabolic side effects. The gut microbiota, influenced by short-chain fatty a...
Subcallosal cingulate functional connectivity in depression: a systematic review of brain stimulation-induced changes and pretreatment connectivity predictors [0.03%]
Adèle Henensal,David Attali,Jean-François Aubry et al.
Adèle Henensal et al.
Major depressive episode (MDE) is a common mental disorder that severely impacts patients' lives and carries a high suicide risk. About 30% of patients are resistant to oral antidepressants, necessitating alternative approaches such as neur...
Thalamocortical functional connectivity alterations and peripheral immune transcriptomic dysregulation in major depressive disorder patients with suicidal ideation [0.03%]
Min Wang,Jinxue Wei,Yushun Yan et al.
Min Wang et al.
Suicidal ideation (SI) in major depressive disorder (MDD) presents a serious clinical concern, yet its underlying biological mechanisms remain poorly understood. Using an exploratory, multimodal design, this study included 98 MDD patients w...
Subanesthetic doses of ketamine to rats and monkeys rapidly increases radioligand binding in brain to phosphodiesterase-4, an indirect marker of cAMP [0.03%]
Paul A Parcon,Amanda Bardhoshi,Amanda Olsen-Dufour et al.
Paul A Parcon et al.
The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine is a robust, rapid-acting antidepressant whose molecular effects have not been fully elucidated. Phosphodiesterase-4 (PDE4), which terminates cyclic adenosine monophosphate (cAMP)...