Amelioration of the brain structural connectivity is accompanied with changes of gut microbiota in a tuberous sclerosis complex mouse model [0.03%]
结节性硬化症小鼠模型中大脑结构连接的改善伴随着肠道微生物群的变化
Christine Chin-Jung Hsieh,Yu-Chun Lo,Hsin-Hui Wang et al.
Christine Chin-Jung Hsieh et al.
Tuberous sclerosis complex (TSC) is a genetic disease that causes benign tumors and dysfunctions in many organs, including the brain. Aside from the brain malformations, many individuals with TSC exhibit neuropsychiatric symptoms. Among the...
Maureen McHugo,Maxwell J Roeske,Simon N Vandekar et al.
Maureen McHugo et al.
Hippocampal volume is smaller in schizophrenia, but it is unclear when in the illness the changes appear and whether specific regions (anterior, posterior) and subfields (CA1, CA2/3, dentate gyrus, subiculum) are affected. Here, we used a h...
Potential causal association between gut microbiome and posttraumatic stress disorder [0.03%]
肠道菌群和创伤后应激障碍之间的潜在因果关联
Qiang He,Wenjing Wang,Dingkang Xu et al.
Qiang He et al.
Background: The causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential causal association using mendelian randomization ...
Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder [0.03%]
成人双相情感障碍患者自杀企图的血液表观遗传全基因组关联研究
Salahudeen Mirza,Camila N C Lima,Alexandra Del Favero-Campbell et al.
Salahudeen Mirza et al.
Suicide attempt (SA) risk is elevated in individuals with bipolar disorder (BD), and DNA methylation patterns may serve as possible biomarkers of SA. We conducted epigenome-wide association studies (EWAS) of blood DNA methylation associated...
Sahar Yassine,Sourour Almarouk,Ute Gschwandtner et al.
Sahar Yassine et al.
Anxiety is a common non-motor symptom in Parkinson's disease (PD) occurring in up to 31% of the patients and affecting their quality of life. Despite the high prevalence, anxiety symptoms in PD are often underdiagnosed and, therefore, under...
Multiomic analysis implicates nuclear hormone receptor signalling in clustering epilepsy [0.03%]
多组学分析揭示核激素受体信号与癫痫的分类有关
Rebekah de Nys,Clare L van Eyk,Tarin Ritchie et al.
Rebekah de Nys et al.
Clustering Epilepsy (CE) is an epileptic disorder with neurological comorbidities caused by heterozygous variants of the X chromosome gene Protocadherin 19 (PCDH19). Recent studies have implicated dysregulation of the Nuclear Hormone Recept...
A zinc finger transcription factor enables social behaviors while controlling transposable elements and immune response in prefrontal cortex [0.03%]
一个锌指转录因子通过控制前额皮质中的可移动元素和免疫反应来促进社会行为
Natalie L Truby,R Kijoon Kim,Gabriella M Silva et al.
Natalie L Truby et al.
The neurobiological origins of social behaviors are incompletely understood. Here we utilized synthetic biology approaches to reprogram the function of ZFP189, a transcription factor whose expression and function in rodent prefrontal cortex...
The effect of continuous theta burst stimulation on antipsychotic-induced weight gain in first-episode drug-naive individuals with schizophrenia: a double-blind, randomized, sham-controlled feasibility trial [0.03%]
连续theta爆发刺激对初发未用药的 schizophrenia患者抗精神病药物引起的体重增加的影响：一项双盲随机假刺激对照可行性试验
Dongyu Kang,Chuhan Song,Xingjie Peng et al.
Dongyu Kang et al.
Antipsychotic intake may induce weight gain in drug-naive individuals with schizophrenia, leading to poor compliance in clinical management. However, there is still a lack of effective approaches to treat or prevent this side-effect. Theref...
Randomized Controlled Trial
Translational psychiatry. 2024 Jan 25;14(1):61. DOI:10.1038/s41398-024-02770-w 2024
Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we? [0.03%]
精神障碍中免疫功能障碍的因果关系的遗传学证据：我们现在处于什么位置？
Olena Iakunchykova,Esten H Leonardsen,Yunpeng Wang
Olena Iakunchykova
The question of whether immune dysfunction contributes to risk of psychiatric disorders has long been a subject of interest. To assert this hypothesis a plethora of correlative evidence has been accumulated from the past decades; however, a...
Identification of a novel perifornical-hypothalamic-area-projecting serotonergic system that inhibits innate panic and conditioned fear responses [0.03%]
鉴定一种新型的抑制先天性恐慌和条件性恐惧反应的位于腹侧帆间区-下丘脑区域的多巴胺能系统
Cristian S Bernabe,Izabela F Caliman,Aline R R de Abreu et al.
Cristian S Bernabe et al.
The serotonin (5-HT) system is heavily implicated in the regulation of anxiety and trauma-related disorders such as panic disorder and post-traumatic stress disorder, respectively. However, the neural mechanisms of how serotonergic neurotra...