DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer [0.03%]
DAB2IP通过调节乳腺癌缺氧条件下的HIF-1α泛素化抑制葡萄糖摄取
Hongliang Dong,Weiyi Jia,Weijian Meng et al.
Hongliang Dong et al.
Metabolic reprogramming has become increasingly important in tumor biology research. The glucose metabolic pathway is a major energy source and is often dysregulated in breast cancer. DAB2IP is widely reported to be a tumor suppressor that ...
Retraction Note: PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas [0.03%]
撤回 notice:PI3K/Akt 途径和 Nanog 在肉瘤癌干细胞的维持中的作用
Changhwan Yoon,Jun Lu,Brendan C Yi et al.
Changhwan Yoon et al.
Retraction of Publication
Oncogenesis. 2024 May 29;13(1):18. DOI:10.1038/s41389-024-00519-0 2024
Retraction Note: Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas [0.03%]
撤回 notice: 血小板源性生长因子受体- α 和 - β 在肉瘤中促进癌症干细胞表型
Kevin K Chang,Changhwan Yoon,Brendan C Yi et al.
Kevin K Chang et al.
Retraction of Publication
Oncogenesis. 2024 May 29;13(1):19. DOI:10.1038/s41389-024-00520-7 2024
Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway [0.03%]
有丝分裂期MTH1抑制剂TH1579通过cGAS-STING信号通路诱导PD-L1表达和炎症反应
Jianyu Shen,Emilio Guillén Mancina,Shenyu Chen et al.
Jianyu Shen et al.
The mitotic MTH1 inhibitor TH1579 is a dual inhibitor that inhibits mitosis and incorporation of oxidative DNA damage and leads to cancer-specific cell death. The response to immune checkpoint inhibitor (ICI) treatment is often augmented by...
An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α [0.03%]
E3泛素连接酶TRIM1通过K63连接的泛素化和活化HIF1α促进结直肠癌进展
Liuliu Shi,Xianglan Fang,Lijie Du et al.
Liuliu Shi et al.
Accumulating studies have shown that E3 ligases play crucial roles in regulating cellular biological processes and signaling pathways during carcinogenesis via ubiquitination. Tripartite-motif (TRIM) ubiquitin E3 ligases consist of over 70 ...
NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development [0.03%]
NAC1转录激活的LDHA诱导乙肝病毒免疫逃逸致肝硬化和肝细胞癌发生
Wenbiao Chen,Liliangzi Guo,Huixuan Xu et al.
Wenbiao Chen et al.
Our study aimed to elucidate the molecular mechanisms underlying NAC1 (nucleus accumbens associated 1) transcriptional regulation of LDHA and its role in HBV immune evasion, thus contributing to the development of cirrhosis and hepatocellul...
Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain [0.03%]
BCL2跨膜结构域癌基因相关体细胞突变表型研究
Diego Leiva,Estefanía Lucendo,Alicia Belén García-Jareño et al.
Diego Leiva et al.
The BCL2 family of proteins controls cell death by modulating the permeabilization of the mitochondrial outer membrane through a fine-tuned equilibrium of interactions among anti- and pro-apoptotic members. The upregulation of anti-apoptoti...
Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development [0.03%]
酸杆菌通过 skewing 中性粒细胞分化和诱导 Th17 极化促进肺腺癌发生发展
Joshua K Stone,Natalia von Muhlinen,Chenran Zhang et al.
Joshua K Stone et al.
Change within the intratumoral microbiome is a common feature in lung and other cancers and may influence inflammation and immunity in the tumor microenvironment, affecting growth and metastases. We previously characterized the lung cancer ...
RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway [0.03%]
RIOK3通过依赖HSP90α通路在葡萄糖缺乏条件下维持结直肠癌细胞生存
Nan Zhang,Lu Dong,Tingting Ning et al.
Nan Zhang et al.
Glucose oxidation via the pentose phosphate pathway serves as the primary cellular mechanism for generating nicotinamide adenine dinucleotide phosphate (NADPH). The central regions of solid tumors typically experience glucose deficiency, em...
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling [0.03%]
基于疗效/毒性整合和二分网络模型设计以患者为中心的急性髓系白血病联合治疗方案
Mehdi Mirzaie,Elham Gholizadeh,Juho J Miettinen et al.
Mehdi Mirzaie et al.
Acute myeloid leukemia (AML), a heterogeneous and aggressive blood cancer, does not respond well to single-drug therapy. A combination of drugs is required to effectively treat this disease. Computational models are critical for combination...