Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer [0.03%]
胰腺癌中防止复发的药物耐受性休眠细胞适应氧化还原代谢的脆弱性
Nadine Abdel Hadi,Gabriela Reyes-Castellanos,Tristan Gicquel et al.
Nadine Abdel Hadi et al.
Pancreatic Ductal Adenocarcinoma (PDAC) remains a major unresolved disease because of its remarkable therapeutic resistance. Even patients who respond to initial therapy experience relapse in most cases. The mechanisms underlying therapy-ac...
Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma [0.03%]
靶向线粒体磷脂酰乙醇胺可改变肝细胞癌中的线粒体代谢和增殖
Melina C Mancini,Cameron P McCall,Robert C Noland et al.
Melina C Mancini et al.
Mitochondrial metabolism is crucial for hepatocellular carcinoma (HCC) to thrive. Although phospholipids modulate mitochondrial metabolism, their impact on metabolism in HCC remains unknown. Here we report that the mitochondrial phospholipi...
CD9, a tetraspanin in cancer: biology and therapeutic promise in acute leukemia [0.03%]
癌症中的四跨膜蛋白CD9：急性白血病中的生物学和治疗潜力
Océane Guého,Elie Cousin,Jérémie Rouger-Gaudichon et al.
Océane Guého et al.
Tetraspanins are transmembrane proteins that organize into functional structures known as tetraspanin-enriched microdomains, where they coordinate interactions with key partner proteins and modulate cellular processes such as adhesion, sign...
Stabilization of FASN by USP5-mediated deubiquitination promotes hepatocellular carcinoma progression [0.03%]
去泛素化酶USP5通过稳定FASN促进肝细胞癌进展
Qinliang Fang,Changhong Luo,Yuyan Lu et al.
Qinliang Fang et al.
The deubiquitinating enzyme Ubiquitin specific peptidase 5 (USP5) has attracted substantial notice for its vital role in cancer progression. However, the USP5-mediated deubiquitination of corresponding protein substrates and its functional ...
ACSL6 modulates docosahexaenoic acid-induced cytotoxicity to potentiate chemotherapy response in colorectal and breast cancer [0.03%]
乙醇胺衍生的溶血磷脂酰胆碱LPC 18:0靶向并杀死胰腺癌细胞
I-Sung Chen,Chi-Che Hsieh,Chun-Chun Li et al.
I-Sung Chen et al.
Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, exhibits anticancer properties by modulating cell membrane composition, inducing oxidative stress, and triggering ferroptosis. Acyl-CoA synthetase long chain family member 6...
Zhenyu Guan,Wendong Li,Yuting He et al.
Zhenyu Guan et al.
RNA modification, a prominent epigenetic mechanism, has been implicated in regulating RNA function, stability, processing, and interactions, including pseudouridylation, acetylation, and methylation. Recent evidence highlights that 5-methyl...
Jason A Powell,Stuart M Pitson
Jason A Powell
Cancer stem cells (CSCs) are considered the head of a hierarchical organisation of carcinogenesis, exhibiting heightened cell survival properties, an ability to endlessly self-renew and undergo attenuated differentiation to maintain the bul...
Pannexin 1 induces Rhabdomyosarcoma cell fusion by downregulating APOBEC2 [0.03%]
泛素1通过下调APOBEC2诱导横纹肌肉瘤细胞融合
Alexandra Welten,Amit Bera,Stéphanie Langlois et al.
Alexandra Welten et al.
Rhabdomyosarcoma (RMS) is an aggressive cancer thought to arise from impaired myogenesis. This can be substantially overcome by increasing the levels of pannexin 1 (PANX1), a critical component of the myogenic program, but the mechanism inv...
YTHDF3 promotes breast cancer osteolytic bone metastasis by enhancing the translation of ZEB1 and SMAD5 [0.03%]
YTHDF3通过增强ZEB1和SMAD5的翻译促进乳腺癌溶骨性骨转移
Lun Xu,Qian Yu,Xu Peihang et al.
Lun Xu et al.
Bone metastsis in advanced breast cancer patients are usually osteolytic. A better understanding of the mechanisms in osteolytic metastasis is critical for the development of new therapies. YTH domain-containing family protein 3 (YTHDF3) ha...
CMKLR1/PKA signaling reinforces sonic hedgehog pathway to promote medulloblastoma pathogenesis [0.03%]
CMKLR1/PKA信号通过增强Sonic Hedgehog通路来促进小脑星形细胞瘤的发生发展
Shan Wang,Tongtong Jiang,Tao Wang et al.
Shan Wang et al.
Aberrant Hedgehog signaling is a key driver of malignancies like medulloblastoma (MB), the most common pediatric brain tumor originating from cerebellar granule neuron progenitors with largely uncharacterized mechanisms. We found here that ...