Apoptosis-driven chromosomal rearrangements in cancer: CAD cleavage, nuclear architecture, and microhomology-mediated end joining [0.03%]
癌症中由细胞凋亡驱动的染色体重排：CAD切割、核结构和微同源介导的末端连接
Sang-Nee Tan
Sang-Nee Tan
Chromosomal rearrangements are hallmarks of many cancers, yet the mechanisms governing breakpoint selection remain incompletely understood. Emerging evidence suggests that sublethal apoptotic signaling may contribute to structural genome re...
Lung adenocarcinoma cell-derived lactate activates CAFs to promote macrophage M2 polarization via exosomal miR-214-5p [0.03%]
肺腺癌细胞来源的乳酸通过外泌体miR-214-5p激活CAF促进巨噬M2极化
Leilei Tao,Fengbiao Guo,Xiaobei Liu et al.
Leilei Tao et al.
Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment that can drive cancer progression and immune evasion. Here, we identify a novel pathway in which lactate produced by lung adenocarcinoma (LUAD) cells acti...
Combined therapy with ALK inhibitors and a novel EGFR-targeting antibody‒drug conjugate as a strategy for ALK-rearranged non-small cell lung cancers [0.03%]
ALK抑制剂与新型EGFR靶向抗体偶联药物联合治疗在ROS1重排非小细胞肺癌中的应用策略
Lanwen Zhang,Xiaofan Wu,Jingfei Gao et al.
Lanwen Zhang et al.
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death. Targeted monotherapies against the actionable oncogenic drivers, including anaplastic lymphoma kinase (ALK) rearrangement and epidermal growth factor rece...
Obesity-driven extracellular vesicle signaling in cancer: mechanistic insights and clinical implications [0.03%]
肥胖驱动的癌症细胞外囊泡信号传导：机制见解与临床意义
Lakshmi Narasimhan Chakrapani,Jessica Velasquez,Joshika Suresh et al.
Lakshmi Narasimhan Chakrapani et al.
Obesity is a rapidly escalating global health challenge and a major, modifiable driver of cancer risk and poor outcomes across at least 13 malignancies, including endometrial, colorectal, breast, pancreatic, hepatic, renal, ovarian, and eso...
Integrated scRNA-Seq and functional profiling reveal CD52 as a driver of pancreatic ductal adenocarcinoma metastasis and immunosuppression [0.03%]
整合scRNA-Seq和功能谱分析揭示CD52是胰腺导管腺癌转移和免疫抑制的驱动因素
Zeyu Zhang,Jinxin Tao,Yifan Fu et al.
Zeyu Zhang et al.
Pancreatic ductal adenocarcinoma (PDAC) remains a highly aggressive malignancy driven by rapid metastasis and a profoundly immunosuppressive microenvironment. While the surface glycoprotein CD52 is a known immunoregulator, its precise role ...
Shensi Shen
Shensi Shen
Editorial Expression of Concern: Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo [0.03%]
撤稿声明：雌激素受体β激活损害线粒体氧化代谢并影响体内外恶性间皮瘤细胞增殖
A G Manente,D Valenti,G Pinton et al.
A G Manente et al.
Extracellular matrix stiffness determines the phenotypic behavior of dedifferentiated melanoma cells through a DDR1/2-dependent YAP mechanotransduction pathway [0.03%]
细胞外基质刚度通过DDR1/2依赖的YAP机械信号转导途径决定黑色素瘤去分化细胞表型行为
Margaux Lecacheur,Ilona Berestjuk,Alexandrine Carminati et al.
Margaux Lecacheur et al.
Extracellular matrix (ECM) stiffening is a biophysical hallmark of solid tumors. Cutaneous melanoma is an aggressive malignancy characterized by high heterogeneity and phenotypic plasticity in which melanoma cells switch from a proliferativ...
Testican-1 activates Wnt/β-Catenin signaling to drive colorectal cancer progression [0.03%]
测试ican-1通过激活Wnt / β-catenin信号传导促进结直肠癌的发展
Yi Li,Chuying Huang,Chu Zhang et al.
Yi Li et al.
Colorectal cancer (CRC) ranks second in cancer-related mortality worldwide. Its clinical intractability and chemoresistance pose significant challenges, often driven by cancer stem cells (CSCs). Wnt/β-catenin signaling is a lynchpin of CSC...
CAF-derived PTGDS drives pancreatic cancer neuroendocrine differentiation and chemoresistance via PAQR9-MAPK [0.03%]
CAF衍生的PTGDS通过PAQR9-MAPK驱动胰腺癌神经内分泌分化和化学耐药性
Jingwen Liang,Wang Peng,Zhou Luan et al.
Jingwen Liang et al.
The tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), critically influences pancreatic ductal adenocarcinoma (PDAC) progression. Neuroendocrine differentiation (NED) is associated with aggressive tumor behavior and ...