Metabolic modulation of immune cell function: mechanisms and therapeutic implications in cancer immunotherapy [0.03%]
代谢调控免疫细胞功能：癌症免疫疗法中的机制和治疗意义
Nina Fenouille,Camille Lobry,Lina Benajiba et al.
Nina Fenouille et al.
Immune cell function is remarkably plastic, allowing T cells, NK cells, and macrophages to transition from resting or quiescent states to proliferative, cytotoxic, or inflammatory programs. These functional shifts are tightly coupled to met...
Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU [0.03%]
泛素特异性蛋白酶11通过调节ISCU的泛素化和稳定性抑制结直肠癌细胞中铜死亡
Hailin Ke,Guowei Zhang,Weili Lin et al.
Hailin Ke et al.
Colorectal cancer (CRC) remains one of the most common and deadly malignancies, with limited effective treatment options. Cuproptosis is a novel regulated cell death triggered by mitochondrial copper overload (Cu2+) and has been implicated ...
HPCAL1 promotes colorectal cancer progression via TCF7/p65-mediated Wnt ligand upregulation and Wnt/β-catenin pathway activation [0.03%]
HPCAL1通过TCF7/p65介导的Wnt配体上调和Wnt/β-catenin信号激活促进结直肠癌进展
Linna Cheng,Huiyang Zhang,Liqun Guo et al.
Linna Cheng et al.
Abnormal Wnt/β-catenin pathway activation drives colorectal cancer (CRC) tumorigenesis, yet effective targeted therapies remain elusive. Given HPCAL1's established dual tumor-suppressive and oncogenic roles in other cancers, this study inv...
Inhibition of LIMK by Cofilin-1 peptidomimetics enhances actin depolymerization and reduces metastasis of non-small cell lung cancer [0.03%]
考利fin-1肽模拟物抑制LIMK促进非小细胞肺癌的微管解聚和降低其转移性
Min-Ying Lin,Jyh-Der Leu,Chun-Yi Wu et al.
Min-Ying Lin et al.
Metastasis is a major contributor to the mortality and morbidity of human non-small cell lung cancer (NSCLC), driven by actin cytoskeletal rearrangements that enhance cancer cell motility and invasiveness. Cofilin-1 (CFL-1), a key actin-bin...
Vinzent L Lindemann,Nazek Noureddine,Raphael J Morscher
Vinzent L Lindemann
Metabolic reprogramming is a defining feature of malignant transformation and cancer cell growth. Pediatric cancers arise from genetic disruptions hijacking developmental programs by aberrant transcriptional networks. This coordinated rewir...
Adam P Dommer,Robert Kyne,Jianxin Wang et al.
Adam P Dommer et al.
CCNE1 (cyclin E) is frequently amplified or overexpressed in triple-negative breast cancer (TNBC) as compared with luminal subtypes. Cyclin E is associated with chromosomal instability and poor outcome, and overexpression promotes replicati...
PRMT6-mediated EZH2 arginine methylation is critical for breast cancer development [0.03%]
PRMT6介导的EZH2精氨酸甲基化对乳腺癌发生发展至关重要
Xue Han,Maoxiang Zhang,Chao Lu et al.
Xue Han et al.
Enhancer of zeste homologue 2 (EZH2), as a key histone methyltransferase, is elevated in multiple malignant tumours, which leads to poor prognosis. However, the underlying mechanisms for mediation of EZH2 enzyme activity remain elusive. Her...
Metastasis suppressing properties of the cell-surface anchored serine protease prostasin: new functional and mechanistic insights from breast cancer [0.03%]
乳腺癌中前列腺素的新功能和机制见解：细胞表面锚定丝氨酸蛋白酶抑制转移的特性
Joseph G Lundgren,Michael G Flynn,Ani R Winkler et al.
Joseph G Lundgren et al.
Serine proteases play multifaceted roles in cancer, affecting tumor formation, progression, and metastasis. While most serine proteases studied act as tumor promoters by remodeling the extracellular matrix and activating signaling pathways,...
SREBP2 regulates CCDC25 expression and promotes tumor metastasis in Triple-Negative Breast Cancer [0.03%]
SREBP2通过调节CCDC25表达促进三阴性乳腺癌转移
Xingxian Lv,Hao Wang,Beibei Liang et al.
Xingxian Lv et al.
This study investigates how cholesterol metabolism promotes metastasis in triple-negative breast cancer (TNBC). By integrating public databases, we identified a positive correlation between the cholesterol metabolism transcription factor SR...
Correction: Oncogenic PI3K/AKT promotes the step-wise evolution of combination BRAF/MEK inhibitor resistance in melanoma [0.03%]
订正：致癌性PI3K/AKT促进组合BRAF/MEK抑制剂在黑色素瘤中产生耐药性的逐步进化
Mal Irvine,Ashleigh Stewart,Bernadette Pedersen et al.
Mal Irvine et al.
Published Erratum
Oncogenesis. 2026 Apr 10;15(1):18. DOI:10.1038/s41389-026-00616-2 2026