Peptidylarginine deiminase 3 modulates response to neratinib in HER2 positive breast cancer [0.03%]
肽基精氨脱亚胺酶3调节HER2阳性乳腺癌对耐拉替尼的反应
Inés Romero-Pérez,Elena Díaz-Rodríguez,Laura Sánchez-Díaz et al.
Inés Romero-Pérez et al.
Neratinib is a tyrosine kinase inhibitor that is used for the therapy of patients with HER2+ breast tumors. However, despite its clinical benefit, resistance to the drug may arise. Here we have created cellular models of neratinib resistanc...
Combined Inhibition of PI3K and STAT3 signaling effectively inhibits bladder cancer growth [0.03%]
PI3K和STAT3信号联合抑制可有效阻止膀胱癌生长
Weidong Peng,Haojie Zhang,Mingwei Yin et al.
Weidong Peng et al.
Bladder cancer is characterized by aberrant activation of the phosphatidylinositol-3-OH kinase (PI3K) signaling, underscoring the significance of directing therapeutic efforts toward the PI3K pathway as a promising strategy. In this study, ...
Merel Elise van Luyk,Ana Krotenberg Garcia,Maria Lamprou et al.
Merel Elise van Luyk et al.
Adult tissues set the scene for a continuous battle between cells, where a comparison of cellular fitness results in the elimination of weaker "loser" cells. This phenomenon, named cell competition, is beneficial for tissue integrity and ho...
USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway [0.03%]
USP32通过去泛素化BAG3并激活RAF-MEK-ERK信号通路促进非小细胞肺癌进展
Shuang Li,Lina Yang,Xiaoyan Ding et al.
Shuang Li et al.
The regulatory significance of ubiquitin-specific peptidase 32 (USP32) in tumor is significant, nevertheless, the biological roles and regulatory mechanisms of USP32 in non-small cell lung cancer (NSCLC) remain unclear. According to our res...
YAP/TAZ interacts with RBM39 to confer resistance against indisulam [0.03%]
YAP/TAZ与RBM39互作以增强细胞对吲哚环素的耐药性
Toshinori Ando,Kento Okamoto,Yume Ueda et al.
Toshinori Ando et al.
The Hippo pathway and its downstream effectors, Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ), are essential for cell growth and organ development. Emerging evidence revealed that the Hippo pathway and ...
Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients [0.03%]
Fanconi贫血症患者的头颈部癌症化疗中的吉西他滨疗法
Anne M van Harten,Ronak Shah,D Vicky de Boer et al.
Anne M van Harten et al.
Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical for the effective repair of DNA interstrand crosslinks (ICLs). The disease is characterized by congenital abnormalitie...
Giovana Carrasco,Ifigeneia Stavrou,Mairi Treanor-Taylor et al.
Giovana Carrasco et al.
Kindler syndrome (KS) is a rare genodermatosis resulting from loss-of-function mutations in FERMT1, the gene that encodes Kindlin-1. KS patients have a high propensity to develop aggressive and metastatic cutaneous squamous cell carcinoma (...
USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling [0.03%]
USP21通过激活Wnt/β-catenin信号促进G3BP1稳定并加速食管鳞癌增殖和转移
Jiazhong Guo,Yunpeng Zhao,Huacong Sui et al.
Jiazhong Guo et al.
Lacking effective therapeutic targets heavily restricts the improvement of clinical prognosis for patients diagnosed with esophageal squamous cell carcinoma (ESCC). Ubiquitin Specific Peptidase 21 (USP21) is dysregulated in plenty of human ...
Comprehensive multi-omics analysis of breast cancer reveals distinct long-term prognostic subtypes [0.03%]
乳腺癌的全面多组学分析揭示了不同的长期预后亚型
Abhibhav Sharma,Julia Debik,Bjørn Naume et al.
Abhibhav Sharma et al.
Breast cancer (BC) is a leading cause of cancer-related death worldwide. The diverse nature and heterogeneous biology of BC pose challenges for survival prediction, as patients with similar diagnoses often respond differently to treatment. ...
Activated platelet-derived exosomal LRG1 promotes multiple myeloma cell growth [0.03%]
活化的血小板源外泌体LRG1促进多发性骨髓瘤细胞的增殖
Meng Gao,Hang Dong,Siyi Jiang et al.
Meng Gao et al.
The hypercoagulable state is a hallmark for patients with multiple myeloma (MM) and is associated with disease progression. Activated platelets secrete exosomes and promote solid tumor growth. However, the role of platelet-derived exosomes ...