Myeloma mesenchymal stem cells' bioenergetics afford a novel selective therapeutic target [0.03%]
骨髓瘤间充质干细胞的生物能量学提供了新的选择性治疗靶点
Oded Komemi,Elina Orbuch,Osnat Jarchowsky-Dolberg et al.
Oded Komemi et al.
Bone-marrow mesenchymal stem cells (BM-MSCs) rely on glycolysis, yet their trafficked mitochondria benefit recipient cells' bioenergetics in regenerative and cancerous settings, most relevant to BM-resident multiple myeloma (MM) cells. Fiss...
A HOTAIR-associated super-enhancer orchestrates glioblastoma malignancy via MEST [0.03%]
HOTAIR相关超级增强子通过MEST调控胶质母细胞瘤恶性表型
Peng Li,Yang Yang,Chunpeng Luan et al.
Peng Li et al.
Glioblastoma (GBM) is one of the most malignant primary brain tumors, and factors governing its progression are not fully characterized. Recent research suggests that the long non-coding RNA (lncRNA) HOTAIR and super-enhancers (SEs) contrib...
FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD+ acute myeloid leukemia [0.03%]
FLT3抑制上调OCT4/NANOG以促进FLT3-ITD+急性髓系白血病的维持和TKI耐药性
Qi Zhou,Zijian Li,Pingping Zhao et al.
Qi Zhou et al.
Up to 30% of acute myeloid leukemia (AML) patients face unfavorable outcomes due to the FMS-like receptor tyrosine kinase-3 (FLT3) internal tandem duplication (ITD) mutation. Although FLT3 inhibitors show encouraging outcomes in treatment, ...
Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming [0.03%]
肿瘤细胞衍生的ISG15通过依赖CD11a的糖酵解重编程促进口腔鳞状细胞癌成纤维细胞募集
Ssu-Han Wang,Yu-Lin Chen,Shih-Han Huang et al.
Ssu-Han Wang et al.
Cancer-associated fibroblast (CAF) recruitment and activation within the tumor microenvironment (TME) are increasingly acknowledged as drivers of oral squamous cell carcinoma (OSCC) tumor growth and metastasis. Therefore, the mechanisms und...
CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma [0.03%]
CENPF (+) 癌细胞促进早期TP53突变肺腺癌的恶性进展
Yanlu Xiong,Jie Lei,Miaomiao Wen et al.
Yanlu Xiong et al.
The prevention and precise treatment of early-stage lung adenocarcinoma (LUAD) characterized by small nodules (stage IA) remains a significant challenge for clinicians, which is due largely to the limited understanding of the oncogenic mech...
STAG2 expression imparts distinct therapeutic vulnerabilities in muscle-invasive bladder cancer cells [0.03%]
STAG2的表达赋予肌层浸润性膀胱癌细胞不同的治疗易感性
Sarah R Athans,Henry Withers,Aimee Stablewski et al.
Sarah R Athans et al.
Expression of stromal antigen 2 (STAG2), a member of the cohesin complex, is associated with aggressive tumor characteristics and worse clinical outcomes in muscle invasive bladder cancer (MIBC) patients. The mechanism by which STAG2 acts i...
Proteomic meta-analysis unveils new frontiers for biomarkers research in pancreatic carcinoma [0.03%]
蛋白质组学荟萃分析揭示了胰腺癌生物标志物研究的新领域
Federica Di Marco,Maria Concetta Cufaro,Verena Damiani et al.
Federica Di Marco et al.
Pancreatic carcinoma (PC) is the sixth leading cause of cancer death in both sexes in 2022, responsible for almost 5% of all cancer deaths worldwide; it is characterized by a poor prognosis since most patients present with an unresectable a...
Subtype-specific role for Jagged1 in promoting or inhibiting breast tumor formation [0.03%]
Jagged1通过促进或抑制乳腺肿瘤的形成在亚型中具有特定作用
Wen-Cheng Chung,Wei Wang,Lavanya Challagundla et al.
Wen-Cheng Chung et al.
Notch signaling is altered in breast cancer. Recent studies highlighted both tumor-suppressive and oncogenic roles for Notch in this tissue. The function of Jagged1, the most highly expressed Notch ligand in the mammary gland, is not well d...
P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker [0.03%]
P4HB维持胶质母细胞瘤干细胞中的Wnt依赖性干性作为精确治疗靶点和血清标志物
Zheng Yuan,Hongbo Jing,Yilin Deng et al.
Zheng Yuan et al.
Glioblastoma stem cells (GSCs) are pivotal in the recurrence and drug resistance of glioblastoma multiforme (GBM). However, precision therapeutic and diagnostic markers for GSCs have not been fully established. Here, using bioinformatics an...
Retraction Note: MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells [0.03%]
撤回 notice:MEK 抑制剂通过 FoxO3a 依赖型诱导 PUMA 在结直肠癌细胞中引起凋亡
Lin Lin,Dapeng Ding,Yanmei Jiang et al.
Lin Lin et al.
Retraction of Publication
Oncogenesis. 2024 Nov 21;13(1):41. DOI:10.1038/s41389-024-00543-0 2024