Targeting macrophage migration inhibitory factor as a potential therapeutic strategy in colorectal cancer [0.03%]
靶向巨噬细胞迁移抑制因子作为结直肠癌潜在的治疗策略
Kim Lucia Schneider,Luisa Claus,Richard Bucala et al.
Kim Lucia Schneider et al.
Survival rates for patients with late-stage colorectal cancer (CRC) remain low due to limited efficacy of current therapeutic regimens. To overcome these challenges, novel drug targets are urgently needed. Macrophage migration inhibitory fa...
Inhibition of LDHB triggers DNA damage and increases cisplatin sensitivity in pleural mesothelioma [0.03%]
抑制LDHB可诱发DNA损伤并增加顺铂对胸膜间皮瘤的敏感性
Yantang Lin,Christelle Dubey,Tereza Losmanova et al.
Yantang Lin et al.
Pleural mesothelioma (PM) is an aggressive, asbestos-linked cancer with limited treatment options and a poor prognosis. Lactate dehydrogenase B (LDHB) converts lactate to pyruvate, and its silencing reduces mitochondrial metabolism, particu...
Novel CDK2/CDK9 inhibitor fadraciclib targets cell survival and DNA damage pathways and synergizes with encorafenib in human colorectal cancer cells with BRAF(V600E) [0.03%]
新型CDK2/CDK9抑制剂fadraciclib靶向细胞存活和DNA损伤通路，并与encorafenib在人结直肠癌BRAF(V600E)细胞中协同作用
Md Mohiuddin,Vanda Póvoa,Rita Fior et al.
Md Mohiuddin et al.
The oncogenic BRAF(V600E) mutation activates the ERK1/2 pathway and is detected in 10% of human colorectal cancers (CRCs) where it is associated with poor prognosis. Inhibitors of BRAF have shown only modest efficacy in patients with CRC du...
Targeting SLC7A5 in lung squamous cell carcinoma: implications for cancer metabolism shift and boron neutron capture therapy resistance [0.03%]
SLC7A5在肺鳞癌中的作用：对肿瘤代谢转变及硼中子俘获治疗抗性的影响
Yen-Ju Lin,Yu-Cheng Wu,Yu-Jui Liu et al.
Yen-Ju Lin et al.
Squamous cell carcinoma (SCC) poses a significant global health challenge due to the lack of effective treatments. Boron neutron capture therapy (BNCT), a targeted particle therapy, has shown promising results in various cancers. SLC7A5, a ...
Ketone drink enhances therapeutic efficacy in prostate cancer by targeting EZH2 [0.03%]
酮饮通过靶向EZH2增强前列腺癌的治疗效果
Chaehyun Yum,Richard A Schaefer,Rui Wang et al.
Chaehyun Yum et al.
It is well established that EZH2, a lysine methyltransferase, is upregulated in most aggressive cancers, highlighting the importance of EZH2 in cancer progression. Recent research has shown that metabolic reprogramming is pivotal in various...
GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells [0.03%]
GSK-3和BCL-XL抑制可缓解APC突变结直肠癌细胞的竞争优势
Le Zhang,Lidia Atencia Taboada,Selami Baglamis et al.
Le Zhang et al.
BCL-XL is a crucial anti-apoptotic protein that supports survival of intestinal cells during the progression and in established colorectal cancer (CRC). While targeting BCL-XL with BH3 mimetics is effective, its significant toxicity highlig...
Collagen type IV alpha 6 promotes tumor progression and chemoresistance in ovarian cancer by activating the discoidin domain receptor 1 pathway [0.03%]
IV型胶原α6通过激活盘状结构域受体1通路促进卵巢癌的进展和耐药性
Yi-Hui Wu,Pei-Ying Wu,Yu-Fang Huang et al.
Yi-Hui Wu et al.
Biomarkers that predict disease progression may assist in the development of better therapeutic strategies for aggressive cancers, such as ovarian cancer. This study aimed to investigate the role of collagen type IV alpha 6 (COL4A6) in cell...
Lipid droplet-associated hydrolase (LDAH) knockdown enhances TAG hydrolysis and promotes ovarian cancer progression and chemoresistance [0.03%]
脂肪滴相关水解酶(LDAH)敲低可增强三酰甘油水解并促进卵巢癌进展及耐药性生成
Bhawna Deswal,Sameera Nallanthighal,Elahe Nikpayam et al.
Bhawna Deswal et al.
Lipid droplet-associated hydrolase (LDAH) is a lipid hydrolase abundantly expressed in adipose and ovarian tissues and macrophages. However, LDAH's functions in ovarian cancer are largely unknown. Analysis of publicly available patient data...
CD147-high extracellular vesicles promote gastric cancer metastasis via VEGF/AKT/eNOS and AKT/mTOR pathways [0.03%]
CD147高表达外泌体通过VEGF/AKT/eNOS和AKT/mTOR途径促进胃癌转移
Chen-Li Zhang,Chan-Yuan Zhao,Jia-Ming Dong et al.
Chen-Li Zhang et al.
Extracellular vesicles (EVs) play a pivotal role in intercellular communication and are closely linked to cancer progression and metastasis. Our previous studies have shown that gastric cancer cell-derived EVs can promote tumor metastasis b...
ONC201 enhances the cytotoxic effect of cisplatin through ATF3/ATF4/CHOP in head and neck squamous cell carcinoma cells [0.03%]
ONC201通过ATF3/ATF4/CHOP增强顺铂对头颈鳞状细胞癌细胞的毒性作用
Hui-Ching Chuang,Ming-Hsien Tsai,Jiin-Haur Chuang et al.
Hui-Ching Chuang et al.
Head and neck squamous cell carcinoma (HNSCC) remains a prevalent and challenging cancer to treat due to its genetic heterogeneity. Cisplatin resistance is one of important causes in treatment failure of locally advanced HNSCC. ONC201, a se...