SLC6A19-mediated tryptophan uptake suppresses renal cell carcinoma metastasis via activating NAD+-dependent deacetylase SIRT1 [0.03%]
SLC6A19介导的色氨酸摄取通过激活NAD +依赖性去乙酰酶SIRT1抑制肾细胞癌转移
Ziyi Chen,Runjie Duan,Zeqing Chen et al.
Ziyi Chen et al.
Metastasis is the hallmark of lethal renal cell carcinoma (RCC), and the underlying mechanism driving RCC metastasis remains insufficiently understood. Amino acid metabolism remodeling plays a key role in the matastasis of RCC. In this stud...
NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression [0.03%]
NFATc1介导的戊糖磷酸途径和细胞周期失调共同驱动肿瘤进展
Suyang Zhang,Guangyao Xu,Tianyu Cao et al.
Suyang Zhang et al.
The pentose phosphate pathway (PPP) supplies abundant reducing equivalents and biosynthetic precursors to support the rapid proliferation of tumor cells. An increased PPP flux is a hallmark of metabolic reprogramming in tumors. Although nuc...
Editorial Expression of Concern: Overexpression of miR-26a-2 in human liposarcoma is correlated with poor patient survival [0.03%]
撤稿声明：人脂肪肉瘤中miR-26a-2高表达与患者预后不良相关性研究
D H Lee,S Amanat,C Goff et al.
D H Lee et al.
Non canonical BRCA1 promotes cell survival via modulating PARP13-mediated SEC61G mRNA decay [0.03%]
非经典型BRCA1通过调节PARP1介导的SEC61G信使RNA降解促进细胞存活
Binghe Sun,Yuting Li,Yue Wu et al.
Binghe Sun et al.
BRCA1, a well-known tumor suppressor, maintains genomic integrity by facilitating homologous recombination (HR) repair and protecting DNA replication forks. However, its roles beyond DNA repair and replication remain largely unexplored. Her...
Investigation of lncRNA expression in newly diagnosed multiple myeloma reveals a LINC01432-CELF2 axis as an inhibitor of apoptosis [0.03%]
新的lncRNA表达调查发现一种LINC01432-CELF2轴可作为新诊断多发性骨髓瘤的凋亡抑制剂
Richa Mishra,Prasanth Thunuguntla,Dhanusha Duraiyan et al.
Richa Mishra et al.
Multiple myeloma (MM) is an incurable malignancy of plasma cells, with over 35,000 new cases diagnosed annually in the United States. Despite an expanding arsenal of approved therapies, nearly all patients relapse, and mechanisms underlying...
GlycoRNAs are abundant in glioma and involved in glioma cell proliferation [0.03%]
糖基化RNA在胶质瘤中大量存在并与胶质瘤细胞增殖有关
Benkai Xin,Jiajun Chen,Xin Hu et al.
Benkai Xin et al.
Recent studies have identified glycosylated RNAs (glycoRNAs) as a novel class of biomolecules potentially involved in cancers and immunological diseases. However, their presence and functional roles in glioma remain unexplored. GlycoRNAs we...
Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse [0.03%]
利用强效配体PROTAC靶向孕烷X受体以延缓结肠癌复发
Lucile Bansard,Guillaume Laconde,Vanessa Delfosse et al.
Lucile Bansard et al.
Tumor recurrence is frequently attributed to drug-tolerant cancer cells. We previously demonstrated that downregulation of the Pregnane X Receptor (PXR, NR1I2) reduces chemoresistance and prevents colorectal cancer recurrence in xenograft m...
A dominant SRCAP truncating mutation promotes squamous cell carcinoma progression [0.03%]
SRCAP截短突变促进鳞状细胞癌进展
Stephenie H Droll,Elena I O Dewar,Celia Xue et al.
Stephenie H Droll et al.
The majority of life-threatening cancers arise from epithelial tissues. These epithelial cancers include cutaneous squamous cell carcinoma (cSCC), the second-most common cancer. cSCC is highly invasive and accounts for an estimated 15,000 d...
BRG1 inhibits glycolysis by promoting SHP1-mediated dephosphorylation of PKM2 in non-small cell lung cancer [0.03%]
BRG1通过促进SHP1介导的PKM2去磷酸化抑制非小细胞肺癌糖酵解作用
Wenli Zhan,Haokun Zhang,Xiaowei She et al.
Wenli Zhan et al.
Glucose metabolic reprogramming serves as a regulatory mechanism to support tumor growth. Here, we identified that BRG1, a subunit of the SWI/SNF chromatin remodeling complex encoded by SMARCA4, can inhibit the glycolysis and proliferation ...
Peroxisomal lipid metabolism inhibits Pimozide-induced cancer cell death by regulating ATP homeostasis [0.03%]
过氧化物酶体脂质代谢通过调节ATP稳态抑制匹莫齐诱导的癌细胞死亡
Zihang Pan,Fazhi Yu,Weiyi You et al.
Zihang Pan et al.
Antipsychotic drugs have been shown to suppress tumor growth and induce cell death, but their clinical application remains limited. Pimozide, an FDA-approved antipsychotic, holds significant potential for cancer treatment. However, the mech...