Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint blockade [0.03%]
深度学习确定了一种T细胞耗竭依赖性转录标志物，可预测临床结果和免疫检查点封锁反应
Zicheng Zhang,Hongyan Chen,Dongxue Yan et al.
Zicheng Zhang et al.
Immune checkpoint blockade (ICB) therapies have brought unprecedented advances in cancer treatment, but responses are limited to a fraction of patients. Therefore, sustained and substantial efforts are required to advance clinical and trans...
MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5 [0.03%]
MLK4通过CREB介导的磷酸烯醇式丙酮酸羧基酶活化促进肺腺癌中的葡萄糖代谢，并由KLF5调节
Alvin Ho-Kwan Cheung,Kit-Yee Wong,Xiaoli Liu et al.
Alvin Ho-Kwan Cheung et al.
MLK4, a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, has been implicated in cancer progression. However, its role in lung adenocarcinoma has not been characterized. Here, we showed that MLK4 was overexpressed...
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice [0.03%]
肿瘤抑制基因CREBBP与致癌基因MYCN在小鼠中合作诱发恶性脑肿瘤
Melanie Schoof,Gefion Dorothea Epplen,Carolin Walter et al.
Melanie Schoof et al.
The tumor suppressor and chromatin modifier cAMP response element-binding protein binding protein (CREBBP) and v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN), a member of the MYC oncogene family, are critic...
Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12 [0.03%]
化疗诱导的执行者半胱天冬酶活化通过表观遗传去激活CDH12增加乳腺癌恶性程度
Yuxing Wang,Ru Wang,Xiaohe Liu et al.
Yuxing Wang et al.
Cancer relapse and metastasis are major obstacles for effective treatment. One important mechanism to eliminate cancer cells is to induce apoptosis. Activation of executioner caspases is the key step in apoptosis and was considered "a point...
Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response [0.03%]
基于抗体的结合域与TCRγ链融合可增强T细胞细胞毒性以实现有效的抗肿瘤反应
Zhao Chen,Changyou Lin,Hong Pei et al.
Zhao Chen et al.
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoietic malignancies. However, the application of CAR-T in solid tumors has been limited due in part to the expression of i...
WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines [0.03%]
WDR5促进N-MYC结合神经母细胞瘤系中保守的WDR5基因靶点
Leigh A Bumpous,Kylie C Moe,Jing Wang et al.
Leigh A Bumpous et al.
Collectively, the MYC family of oncoprotein transcription factors is overexpressed in more than half of all malignancies. The ability of MYC proteins to access chromatin is fundamental to their role in promoting oncogenic gene expression pr...
Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma [0.03%]
单细胞和批量RNA测序数据的综合分析揭示了骨肉瘤肿瘤血栓免疫刺激性微环境
Tao Ji,Qianyu Shi,Song Mei et al.
Tao Ji et al.
Tumor thrombus of bone sarcomas represents a unique reservoir for various types of cancer and immune cells, however, the investigation of tumor thrombus at a single-cell level is very limited. And it is still an open question to identify th...
Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity [0.03%]
AKT介导的IWS1磷酸化通过维持癌干细胞表型和间充质上皮可塑性来保持脂肪肉瘤异质性
Yu Wang,Hongji Zhang,Alessandro La Ferlita et al.
Yu Wang et al.
Chemotherapy remains the mainstay of treatment for patients with advanced liposarcoma (LPS), but response rates are only 25% and the overall survival at 5 years is dismal at 20-34%. Translation of other therapies have not been successful an...
CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer [0.03%]
CDK4/6抑制剂和pRB-E2F1轴通过下调PVR和PD-L1表达抑制三阴性乳腺癌
Mariusz Shrestha,Dong-Yu Wang,Yaacov Ben-David et al.
Mariusz Shrestha et al.
Immune-checkpoint (IC) modulators like the poliovirus receptor (PVR) and programmed death ligand 1 (PD-L1) attenuate innate and adaptive immune responses and are potential therapeutic targets for diverse malignancies, including triple-negat...
Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data [0.03%]
Circlehunter：一种从ATAC-seq数据中识别细胞器环状DNA的工具
Manqiu Yang,Shufan Zhang,Rong Jiang et al.
Manqiu Yang et al.
In cancer, extrachromosomal circular DNA (ecDNA), or megabase-pair amplified circular DNA, plays an essential role in intercellular heterogeneity and tumor cell revolution because of its non-Mendelian inheritance. We developed circlehunter ...