Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis [0.03%]
流体剪切应力通过激活可靶向的机械-转移性级联促进髓母细胞瘤转移
Hyun-Kee Min,Hongyu Zhao,Alexander Bahcheli et al.
Hyun-Kee Min et al.
Biofluid flow generates fluid shear stress (FSS), a mechanical force widely present in the tissue microenvironment. How brain tumour growth alters the conduit of biofluid and impacts FSS-regulated cancer progression is unknown. Disseminatio...
Distributed battery-free bioelectronic implants with improved network power transfer efficiency via magnetoelectrics [0.03%]
基于磁电效应的分布式无电池生物电子植入器件及其高效的网络供能方法
Joshua E Woods,Fatima Alrashdan,Ellie C Chen et al.
Joshua E Woods et al.
Networks of miniature implants could enable simultaneous sensing and stimulation at different locations in the body, such as the heart and central or peripheral nervous system. This capability would support precise disease tracking and trea...
A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity [0.03%]
一种模块化疫苗平台，可优化脂质纳米颗粒mRNA的免疫原性
Zhenhao Fang,Valter S Monteiro,Changin Oh et al.
Zhenhao Fang et al.
Certain messenger RNA antigens in mRNA vaccines elicit an insufficient immune response due to challenges in cell surface translocation (CST) of the antigens. Here we develop a modular vaccine platform (MVP) to enhance the immunogenicity of ...
Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells [0.03%]
基于定向进化的靶向CAR-T细胞体内刺激的配体筛选方法
Tomasz M Grzywa,Alexandra Neeser,Ranjani Ramasubramanian et al.
Tomasz M Grzywa et al.
Chimeric antigen receptor (CAR) T cell therapy targeting CD19 elicits remarkable clinical efficacy in B cell malignancies, but many patients relapse owing to failed expansion and/or progressive loss of CAR-T cells. We recently reported a st...
Multiparametric cellular and spatial organization in cancer tissue lesions with a streamlined pipeline [0.03%]
具有精简管线的癌组织损伤中的多参数细胞和空间组织
Mark Buckup,Igor Figueiredo,Giorgio Ioannou et al.
Mark Buckup et al.
Multiplex immunostaining analysis remains fragmented, underperforming and labour intensive despite tissue proteomic methodologies achieving ever-increasing marker complexity. Here we propose an open-source, user-guided automated pipeline th...
Junhao Wen
Junhao Wen
Zakary S Singer,Jonathan Pabón,Hsinyen Huang et al.
Zakary S Singer et al.
The ability of bacteria and viruses to selectively replicate in tumours has led to synthetic engineering of new microbial therapies. Here we design a cooperative strategy whereby Salmonella typhimurium bacteria transcribe and deliver the Se...
GenomePAM directs PAM characterization and engineering of CRISPR-Cas nucleases using mammalian genome repeats [0.03%]
利用哺乳动物基因组重复序列表征和改造CRISPR-Cas核酸酶的PAM GenomePAM
Miao Yu,Limei Ai,Bang Wang et al.
Miao Yu et al.
Characterizing the protospacer adjacent motif (PAM) requirements of different Cas enzymes is a bottleneck in the discovery of Cas proteins and their engineered variants in mammalian cell contexts. Here, to overcome this challenge and to ena...
Author Correction: Small circular RNAs as vaccines for cancer immunotherapy [0.03%]
作者更正：作为癌症免疫疗法疫苗的小圆rna
Yu Zhang,Xiang Liu,Tingting Shen et al.
Yu Zhang et al.
Published Erratum
Nature biomedical engineering. 2025 Aug 12. DOI:10.1038/s41551-025-01490-w 2025
In vivo genome editing of human haematopoietic stem cells for treatment of blood disorders using mRNA delivery [0.03%]
使用mRNA递送对人类造血干细胞进行体内基因组编辑以治疗血液疾病
Saijuan Xu,Dan Liang,Qiudao Wang et al.
Saijuan Xu et al.
Ex vivo autologous haematopoietic stem cell (HSC) gene therapy provides a promising treatment option for haematological disorders. However, current methods involve complex processes and chemotherapeutic conditioning, leading to limited acce...