EU's fragmented early-stage medical device study requirements need reform [0.03%]
欧盟碎片化的早期阶段医疗器械研究要求需要改革
Muhammad Ibtsaam Qadir,Juliane Wober,Ali McDonnell et al.
Muhammad Ibtsaam Qadir et al.
Sulfated polysaccharides target RANK Lys97 to inhibit osteoclast differentiation and reverse osteoporosis [0.03%]
硫酸化多糖靶向RANK-Lys97抑制破骨细胞分化及治疗骨质疏松症
Xiaogang Wang,Luli Ji,Yuanman Yu et al.
Xiaogang Wang et al.
Current osteoporosis treatments fail to balance bone resorption and formation. Here we show that engineered 2-N,6-O-sulfated chitosan (26SCS), a synthetic pentasaccharide, restores 115% bone mass (therapeutic) and prevents 66% bone loss, su...
Shounak Roy,Akhilesh K Gaharwar
Shounak Roy
Anett Schönfelder,Alastair K Denniston,Alejandro F Frangi et al.
Anett Schönfelder et al.
Shraddha Shirguppe,Michael Gapinske,Devyani Swami et al.
Shraddha Shirguppe et al.
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat within exon 1 of the huntingtin (HTT) gene, resulting in a mutant protein that drives neuronal dysfunction and loss. A key event in the pathoge...
Sequencing-free spatial profiling of post-transcriptional regulation in fresh tissues using nanoneedle arrays [0.03%]
基于纳米针阵列的组织切片转录后调控空间分布分析技术
Xianglin Ji,Peilin Fang,Youyang Wan et al.
Xianglin Ji et al.
Spatial transcriptomics has transformed tissue analysis but remains constrained by high cost, complex workflows, sequencing dependence and limited access to post-transcriptional regulation in fresh tissues. Here we present a sequencing-free...
A PET reporter ligand for quantitative imaging of gene expression in the brain [0.03%]
一种用于大脑基因表达定量成像的正电子发射断层扫描报告分子ligand
Sophie Stotz,Gina Dunkel,Sabrina Haas et al.
Sophie Stotz et al.
The lack of brain penetrant and biologically stable positron emission tomography reporter systems hampers the development of neurological disease models and the monitoring of gene delivery because existing approaches depend on endogenous re...
Atmospheric water harvesting for humidity control in medical devices for global health [0.03%]
用于全球卫生医疗设备的湿度控制型大气水采集技术
Weixin Guan,Yaxuan Zhao,Bozhi Tian et al.
Weixin Guan et al.
Atmospheric water harvesting (AWH), which captures water from air, either by condensing humid air or by using sorbents that bind and release water vapour, is being explored as a decentralized source of clean water where piped supply is abse...
Voxel-scale diffusion tensor phenomapping of the healthy and pressure-overloaded human heart [0.03%]
正常心脏和压力超负荷人类心脏的体素尺度扩散张量表型映射
Christopher A Rock,Y Iris Chen,Ruopeng Wang et al.
Christopher A Rock et al.
Diffusion tensor magnetic resonance imaging of the heart is typically performed at millimetre-scale resolution, yielding only four to five voxels across the ventricular wall, limiting the measurement of local spatial variation in cardiomyoc...
Pathology-CoT: learning visual chain-of-thought agents from expert whole-slide image diagnosis behaviour [0.03%]
病理学-COT：从专家的整个载玻片图像诊断行为中学习视觉链式思维代理
Sheng Wang,Ruiming Wu,Charles Herndon et al.
Sheng Wang et al.
Diagnosing a whole-slide image is an interactive, multistage process, yet practical agentic systems that navigate fields, adjust magnification and deliver explainable diagnoses remain lacking, largely because the tacit, experience-based vie...