Electrically functionalized body surface for deep-tissue bioelectrical recording [0.03%]
电动功能化身体表面技术用于深层组织生物电记录
Dehui Zhang,Ganggang Zhao,Yucheng Zhang et al.
Dehui Zhang et al.
Non-invasive monitoring of deep-tissue physiological processes from the body surface is technically challenging due to rapid signal attenuation and severe motion artefacts, primarily caused by high contact impedance and mechanical mismatch ...
An injectable hydrogen-producing bacteria hydrogel for cardiac repair in rodent and porcine models [0.03%]
一种可注射的产氢细菌水凝胶在啮齿类和猪心脏修复模型中的应用
Li Luo,Yingxian Xiao,Qiaocong Lao et al.
Li Luo et al.
Cardioprotective effects of current therapies for mitigating ischaemia/reperfusion (I/R) injury have had limited success. The major challenge is to effectively control oxidative stress while preserving mitochondrial function in a timely man...
Modular nucleic acid-based construct for delivery of immunostimulatory agonists and oncogene-silencing oligonucleotides in tumours [0.03%]
一种用于在肿瘤组织中递送免疫刺激激动剂和抑癌寡核苷酸的模块化核酸构建体
Hongli Chi,Keli An,Jiaxuan He et al.
Hongli Chi et al.
Systemic delivery of nucleic acid therapeutics to tissues outside the liver remains difficult because of rapid clearance, off-target accumulation and inefficient cellular uptake. Here we developed a multifunctional construct that assembles ...
Chen Gong,Gengxi Lu,Baoqiang Liu et al.
Chen Gong et al.
Cardiac pacemakers are critical for treating heart rhythm disorders, but traditional implants are associated with great risks and complications owing to their invasive nature. Here we introduce a wearable non-invasive ultrasound pacemaker (...
4D-printed adaptive hydrogel tissue expanders for ear and breast reconstruction [0.03%]
用于耳和乳腺重建的4D打印自适应水凝胶组织展开器
Di Wang,Jia-Qi Lü,Xiao Kuang et al.
Di Wang et al.
Tissue expanders are widely used for organ and tissue reconstruction surgery. Hydrogel tissue expanders that swell in a biofluid are promising for minimally invasive operations. Nevertheless, clinical applications of existing hydrogel tissu...
Author Correction: Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons [0.03%]
作者更正：用于增强向神经元递送mRNA的囊泡摄取类似逆转录病毒的衣壳蛋白质质体
Wenchao Gu,Sijin Luozhong,Simian Cai et al.
Wenchao Gu et al.
Published Erratum
Nature biomedical engineering. 2026 May 27. DOI:10.1038/s41551-026-01721-8 2026
Cell-based cytokine patch for localized immunomodulation and accelerated healing in rodent and porcine wounds [0.03%]
用于啮齿动物和猪伤口局部免疫调节和加速愈合的基于细胞的细胞因子贴片
Christian C Schreib,Elizabeth L Kelley,Gillian Audia et al.
Christian C Schreib et al.
Wounds can become chronic if the biological processes that coordinate tissue repair, including immune cell activity and matrix remodelling, become dysregulated. Current treatments mainly focus on a wound's physical properties, such as moist...
Large-scale and innervated functional human gut tissues for transplantation via transient spheroid confinement [0.03%]
通过短暂的类器官培养获得可用于移植的大规模功能性人体肠道组织
Holly M Poling,Théo Noël,Akaljot Singh et al.
Holly M Poling et al.
Key limitations of current human gastrointestinal organoids include incomplete physiological maturation and the need for complex, time-consuming assembloid approaches to integrate a functional nervous system for transplantation. Here we pre...
Author Correction: Polymer-mRNA complexes for monocyte-trafficked, lymph node-targeted cancer vaccination [0.03%]
作者更正：用于单核细胞运输、淋巴结靶向癌症疫苗的聚合物-mRNA复合物
Qiongzhe Ren,Xiaofei Zhao,Lili Zhou et al.
Qiongzhe Ren et al.
Published Erratum
Nature biomedical engineering. 2026 May 21. DOI:10.1038/s41551-026-01710-x 2026
Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects [0.03%]
人炎症性肠病芯片：疾病进展、癌症发生及性别特异性效应模型研究
Alican Özkan,Gwenn E Merry,David B Chou et al.
Alican Özkan et al.
Patients affected by inflammatory bowel disease (IBD) exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis and cancer risk, with symptoms often being exacerbated in wo...