Targeted lipid nanoparticles unlock in vivo human haematopoietic stem cell gene editing [0.03%]
靶向脂质纳米颗粒解锁体内人体造血干细胞基因组编辑
Zhangyi Luo,Audrey T Zhu,Michael J Mitchell
Zhangyi Luo
Intracellular protein binders for imaging, control and future therapeutics [0.03%]
用于成像、控制及未来治疗的细胞内蛋白质结合剂
Natalia V Barykina,Vladislav V Verkhusha
Natalia V Barykina
Intracellular protein dysregulation underlies many cancers, neurodegenerative disorders and infectious diseases, yet a substantial fraction of the human proteome remains inaccessible to conventional small-molecule drugs or extracellular ant...
Gue-Ho Hwang,Benjamin Vyshedskiy,Timothy Barry et al.
Gue-Ho Hwang et al.
Long-read sequencing can characterize complex genome editing-induced DNA sequence changes such as large deletions, insertions and inversions that are difficult to detect using short-read sequencing. However, PCR amplification and sequencing...
A miniature endovascular soft robot for active blood flow regulation in occluded vessels [0.03%]
一种微型血管内软机器人 可主动调节闭塞血管的血流
Kaiwen Fang,Yibin Wang,Jiguang Liang et al.
Kaiwen Fang et al.
Blood flow abnormalities in occluded or narrowed vessels limit drug delivery and contribute to recurrent vascular disease. Existing endovascular or pharmacological approaches do not directly address impaired local flow. Here we propose a mi...
An explainable biomedical foundation model via large-scale concept-enhanced vision-language pretraining [0.03%]
基于大规模概念增强的视觉语言预训练的可解释生物医学基础模型
Yuxiang Nie,Sunan He,Yequan Bie et al.
Yuxiang Nie et al.
Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, ...
Biomimetic zona pellucida-encapsulated islets for sustained glycaemic control in immunocompetent mice [0.03%]
模拟 zona pellucida 透明带的胶囊化细胞团用于免疫健全小鼠的长期血糖控制
Kyungsene Lee,Xuelin Wang,Connie Wen et al.
Kyungsene Lee et al.
Islet transplantation is a promising therapy for treating type 1 diabetes. Thin capsules, although offering numerous advantages over thicker ones in islet transplantation, pose persistent challenges for ensuring long-term cell protection. H...
Amgad Muneer,Kai Zhang,Ibraheem Hamdi et al.
Amgad Muneer et al.
Foundation models (FMs) are driving a prominent shift in biomedical imaging, from task-specific models to unified backbone models for diverse tasks. This opens an avenue to integrate imaging, pathology, clinical records and genomics data in...
Author Correction: The evolving role of cytokines for CAR-T cell manufacturing and beyond [0.03%]
作者更正：细胞因子在CAR-T细胞制备及其他领域的演变作用
Mar Guaza-Lasheras,Johanna Nimmerfroh,Dominic Schwarz et al.
Mar Guaza-Lasheras et al.
Published Erratum
Nature biomedical engineering. 2026 Aug 10. DOI:10.1038/s41551-026-01783-8 2026
Munib Mesinovic,Max Buhlan,Tingting Zhu
Munib Mesinovic
Healthcare artificial intelligence systems often degrade in performance when deployed across institutions, with documented performance drops and perpetuation of discriminatory patterns embedded in data. This brittleness comes, in part, from...