A selection pipeline for switchable aptamer beacons in broad-spectrum protein detection [0.03%]
用于广谱蛋白质检测的可切换适配子信标的筛选方法
Maxim V Berezovski
Maxim V Berezovski
Leveraging large language and vision models for knowledge extraction from large-scale image-text colonoscopy records [0.03%]
利用大规模图像文本结肠镜记录进行知识提取的语言和视觉模型的应用
Shuo Wang,Yan Zhu,Zhiwei Yang et al.
Shuo Wang et al.
The development of artificial intelligence systems for colonoscopy analysis often necessitates expert-annotated image datasets. However, limitations in dataset size and diversity impede model performance and generalization. Image-text colon...
Label-free metabolic imaging monitors the fitness of chimeric antigen receptor T cells [0.03%]
无标签代谢成像监测嵌合抗原受体T细胞的适应度
Dan L Pham,Dan Cappabianca,Matthew H Forsberg et al.
Dan L Pham et al.
Chimeric antigen receptor (CAR) T cell therapy for solid tumours is challenging because of the immunosuppressive tumour microenvironment and a complex manufacturing process. Cellular manufacturing protocols directly impact CAR T cell yield,...
Treatment of a severe vascular disease using a bespoke CRISPR-Cas9 base editor in mice [0.03%]
利用定制的CRISPR-Cas9碱基编辑器治疗小鼠重度血管疾病的研究
Christiano R R Alves,Sabyasachi Das,Vijai Krishnan et al.
Christiano R R Alves et al.
Pathogenic missense mutations in the alpha actin isotype 2 (ACTA2) gene cause multisystemic smooth muscle dysfunction syndrome (MSMDS), a genetic vasculopathy that is associated with stroke, aortic dissection and death in childhood. Here we...
Combinatorial prediction of therapeutic perturbations using causally inspired neural networks [0.03%]
基于因果启发式神经网络的治疗扰动组合预测方法
Guadalupe Gonzalez,Xiang Lin,Isuru Herath et al.
Guadalupe Gonzalez et al.
Phenotype-driven approaches identify disease-counteracting compounds by analysing the phenotypic signatures that distinguish diseased from healthy states. Here we introduce PDGrapher, a causally inspired graph neural network model that pred...
A generalist foundation model and database for open-world medical image segmentation [0.03%]
通用基础模型和数据库用于开放世界的医学图像分割
Siqi Zhang,Qizhe Zhang,Shanghang Zhang et al.
Siqi Zhang et al.
Vision foundation models have demonstrated vast potential in achieving generalist medical segmentation capability, providing a versatile, task-agnostic solution through a single model. However, current generalist models involve simple pre-t...
Yuki Yamato,Jun Suzuki
Yuki Yamato
During the process of engulfment, phosphatidylserine is exposed on the surface of dead cells as an 'eat-me' signal and is recognized by Protein S (ProS), a secreted factor that also binds to the Mer tyrosine kinase (MerTK) on phagocytes. De...
A generalizable pathology foundation model using a unified knowledge distillation pretraining framework [0.03%]
一种使用统一知识蒸馏预训练框架的可泛化的病理基础模型
Jiabo Ma,Zhengrui Guo,Fengtao Zhou et al.
Jiabo Ma et al.
The generalization ability of foundation models in the field of computational pathology (CPath) is crucial for their clinical success. However, current foundation models have only been evaluated on a limited type and number of tasks, leavin...