Artificial intelligence-guided design of LNPs for in vivo targeted mRNA delivery via analysis of the spatial conformation of ionizable lipids [0.03%]
基于离子可交换脂质空间构象分析的AI辅助体内靶向mRNA递送LNP设计
Lin-Jia Su,Nan-Nan Wang,Rui Luo et al.
Lin-Jia Su et al.
Efficient mRNA delivery to specific tissues requires optimized ionizable lipids, yet the role of lipid spatial conformation in organ targeting and endosomal escape remains underexplored. Here we developed a library of lipids with diverse am...
Engineering an in vivo charging station for CAR-redirected invariant natural killer T cells to enhance cancer therapy [0.03%]
工程化体内充电站以增强CAR重定向的不变自然杀伤T细胞癌症治疗效果
Yan-Ruide Li,Haochen Nan,Zeyang Liu et al.
Yan-Ruide Li et al.
Invariant natural killer T (iNKT) cells are a unique subset of T lymphocytes with allogeneic potential and strong solid tumour-homing capacity, making them attractive for cancer immunotherapy. Unlike conventional T cells, iNKT cells recogni...
'Tripod-like' lung-targeting (LuT) lipids for highly efficient and selective LNPs for gene delivery and editing [0.03%]
“三脚架”式肺部靶向(LuT)脂质，用于基因传递和编辑的高效且选择性LNPs
Zeru Tian,Xu Wang,Sumanta Chatterjee et al.
Zeru Tian et al.
Developing lung-targeting delivery systems is essential for treating pulmonary conditions such as genetic respiratory diseases, infections, fibrosis and cancer. We synthesized and evaluated 444 lung-targeting lipids (LuT lipids) that form l...
DNA origami vaccine nanoparticles improve humoral and cellular immune responses to infectious diseases [0.03%]
DNA折纸疫苗纳米颗粒可改善对传染病的体液免疫和细胞免疫反应
Yang C Zeng,Olivia J Young,Qiancheng Xiong et al.
Yang C Zeng et al.
Current SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccines have shown robust induction of neutralizing antibodies and CD4+ T cell activation; however, CD8+ responses are variable, and the duration of immunity and protecti...
Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury [0.03%]
脊髓损伤患者的 peri-病灶神经调控可替代丧失的感官和运动功能
Jonathan S Calvert,Samuel R Parker,Lakshmi N Govindarajan et al.
Jonathan S Calvert et al.
Spinal cord injury (SCI) results in permanent impairment of sensory, motor and autonomic function. Epidural electrical stimulation (EES) applied below the lesion can restore voluntary movement, autonomic function and locomotion following ch...
Rapid and sensitive detection of cancer-derived small extracellular vesicles using Janus particles [0.03%]
一种使用 janus 颗粒快速灵敏检测癌症来源的小细胞外囊泡的方法
Sonu Kumar,John Alex Sinclair,Tiger Shi et al.
Sonu Kumar et al.
Detecting small extracellular vesicles is critical for understanding disease biology and developing diagnostic tools, yet current methods require lengthy isolation steps and lack sensitivity owing to interference from abundant proteins. Her...
Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer [0.03%]
预测嵌合抗原受体(T细胞)疗法对血液系统恶性肿瘤患者反应的生物标志物
Gregory M Chen,Ankita Jain,David T Gering et al.
Gregory M Chen et al.
Chimeric antigen receptor (CAR) T-cell therapy holds great promise for patients with cancer, and the identification of predictive biomarkers is crucial in finding new ways to guide therapy. Major challenges to the application of informatics...
Author Correction: Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation [0.03%]
作者更正：为慢性自适应深部脑刺激获取皮质记录的挑战与机遇
Jeffrey Herron,Aura Kullmann,Timothy Denison et al.
Jeffrey Herron et al.
Published Erratum
Nature biomedical engineering. 2026 Mar 3. DOI:10.1038/s41551-026-01641-7 2026
An ophthalmic video foundation model for surgical recognition and navigation with wet-lab porcine eye validation [0.03%]
一种用于手术识别和导航的ocular视频基础模型，并通过湿实验室猪眼验证其有效性
Puxun Tu,Ce Zheng,Xiaoling Xie et al.
Puxun Tu et al.
Foundation models in artificial intelligence are revolutionizing healthcare by utilizing large-scale unlabelled data for pretraining. However, their intraoperative applications remain underexplored owing to limited surgical data and the cha...
Low-input deep learning platform for citrullinated peptide identification, autoantigen discovery and rheumatoid arthritis treatment stratification [0.03%]
低输入深度学习平台在瓜氨酸肽识别、自身抗原发现和类风湿关节炎治疗分层中的应用
Meng Hu,Chenxi Zhu,Rui Sun et al.
Meng Hu et al.
Post-translationally modified proteins are crucial autoantigens in autoimmune diseases, with citrullinated proteins being key targets of autoantibodies in rheumatoid arthritis (RA). However, accurate citrullinome profiling and autoantigen i...