Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants [0.03%]
侵入式神经生理学和全脑连接组学在植入大脑装置的患者中的神经解码中的应用
Timon Merk,Richard M Köhler,Toni M Brotons et al.
Timon Merk et al.
Brain-computer interface research can inspire closed-loop neuromodulation therapies, promising spatiotemporal precision for the treatment of brain disorders. Decoding dynamic patient states from brain signals with machine learning is requir...
An artificial cilia-based array system for sound frequency decoding and resonance-responsive drug release [0.03%]
一种人工纤毛阵列系统用于声音频率解码和共振响应药物释放
Xinwei Wei,Hanlin Wang,Yanfang Wang et al.
Xinwei Wei et al.
Hair cells in the human ear contain cilia of varying lengths that sense varied acoustic signals. Here, inspired by this, we report an artificial cilia-based sound-decoding device capable of directly recognizing and responding to sound frequ...
An immune-competent lung-on-a-chip for modelling the human severe influenza infection response [0.03%]
一个用于模拟人类严重流感感染反应的免疫型肺芯片
Rachel Ringquist,Eshant Bhatia,Paramita Chatterjee et al.
Rachel Ringquist et al.
Severe influenza affects 3-5 million people worldwide each year, resulting in more than 300,000 deaths annually. However, standard-of-care antiviral therapeutics have limited effectiveness in these patients. Current preclinical models of se...
Hongjian Zhou,Fenglin Liu,Jinge Wu et al.
Hongjian Zhou et al.
Large language models (LLMs), such as ChatGPT, have substantially helped in understanding human inquiries and generating textual content with human-level fluency. However, directly using LLMs in healthcare applications faces several problem...
Author Correction: Cancer biomarkers discovered using pan-cancer plasma proteomic profiling [0.03%]
作者更正：使用全癌症血浆蛋白质组学分析发现癌症生物标志物
Lin Bai,Jiacheng Lyu,Jinwen Feng et al.
Lin Bai et al.
Published Erratum
Nature biomedical engineering. 2025 Sep 22. DOI:10.1038/s41551-025-01541-2 2025
Intranasal vaccine combining adenovirus and trimeric subunit protein provides superior immunity against SARS-CoV-2 Omicron variant [0.03%]
针对新冠病毒奥密克戎变异株的鼻喷新冠疫苗（结合腺病毒载体与三聚体蛋白亚单位）可提供更佳免疫防护作用
Weiqi Hong,Ping Cheng,Jingyun Yang et al.
Weiqi Hong et al.
Mucosal immunity provides efficient protection against upper-airway infections, limiting viral shedding and transmission. However, currently, no nasal spray COVID-19 vaccines are approved by WHO for global use. Here we develop a two-compone...
Bead-based approaches for increased sensitivity and multiplexing of CRISPR diagnostics [0.03%]
基于珠子的方法，提高CRISPR诊断的灵敏度和多重检测能力
Sameed M Siddiqui,Nicole L Welch,Tien G Nguyen et al.
Sameed M Siddiqui et al.
CRISPR-based diagnostics have emerged as a promising tool for fast, accurate and portable pathogen detection. There has been rapid progress in pre-amplification processes and CRISPR-related enzymes used in these approaches, but the developm...
Spatial profiling of gene editing by in situ sequencing in mice and macaques [0.03%]
通过原位测序在小鼠和恒河猴中对基因编辑的空间定位分析
Sharan Janjuha,Tatjana Haenggi,Thomas C Chamberlain et al.
Sharan Janjuha et al.
Base and prime editing technologies precisely install defined nucleotide edits in both dividing and non-dividing cells, offering potential for correcting pathogenic mutations directly in organisms. However, to fully leverage their therapeut...
Xuan Cheng,Panzhu Yao,Chongyu Jin et al.
Xuan Cheng et al.
Immunoassays using affinity binders such as antibodies and aptamers are crucial for molecular biology. However, the advancement of analytical methods based on these affinity probes is often hampered by complex operational steps that can int...