Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation [0.03%]
一种用于多模态神经解码和刺激的可扩展高密度皮层微电极阵列的微创植入方法
Mark Hettick,Elton Ho,Adam J Poole et al.
Mark Hettick et al.
High-bandwidth brain-computer interfaces rely on invasive surgical procedures or brain-penetrating electrodes. Here we describe a cortical 1,024-channel thin-film microelectrode array and we demonstrate its minimally invasive surgical deliv...
Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation [0.03%]
用于多模式神经解码和刺激的可扩展高密度皮层微电极阵列的微创植入
Mark Hettick,Elton Ho,Adam J Poole et al.
Mark Hettick et al.
High-bandwidth brain-computer interfaces rely on invasive surgical procedures or brain-penetrating electrodes. Here we describe a cortical 1,024-channel thin-film microelectrode array and we demonstrate its minimally invasive surgical deliv...
Xiangzhe Kong,Rui Jiao,Haowei Lin et al.
Xiangzhe Kong et al.
Peptides offer advantages for targeted therapy, including oral bioavailability, cellular permeability and high specificity, setting them apart from conventional small molecules and biologics. Here we develop an artificial intelligence algor...
Benchmarking foundation models as feature extractors for weakly supervised computational pathology [0.03%]
基础模型作为弱监督计算病理学特征提取器的基准测试
Peter Neidlinger,Omar S M El Nahhas,Hannah Sophie Muti et al.
Peter Neidlinger et al.
Numerous pathology foundation models have been developed to extract clinically relevant information. There is currently limited literature independently evaluating these foundation models on external cohorts and clinically relevant tasks to...
Junwon Kang,Hamin Kim,Haewook Jang et al.
Junwon Kang et al.
Biopharmaceuticals are emerging as viable alternatives to chemically synthesized drugs for potential treatment to various diseases. However, many of these human-derived components cannot withstand terminal sterilization procedures, and the ...
Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery [0.03%]
工程化针对PD-L1的CAR-T细胞融合蛋白用于局部递送IL-12治疗实体瘤
John P Murad,Lea Christian,Reginaldo Rosa et al.
John P Murad et al.
Chimeric antigen receptor (CAR)-T cell efficacy in solid tumours is limited due in part to the immunosuppressive tumour microenvironment (TME). To improve antitumour responses, we hypothesized that enabling CAR-T cells to secrete bifunction...
Targeted clearance of extracellular Tau using aptamer-armed monocytes alleviates neuroinflammation in mice with Alzheimer's disease [0.03%]
靶向清除阿尔茨海默病模型小鼠中的Tau蛋白可减轻神经炎症
Yuting Zhuo,Yao Lu,Yan Zhu et al.
Yuting Zhuo et al.
Extracellular Tau determines the progression of Alzheimer's disease, yet therapeutic strategies targeting it are hindered by poor brain delivery and limited clearance. Here we developed a Tau-clearing cell therapy based on monocytes functio...
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue [0.03%]
帕金森病脑组织中寡聚α-突触核蛋白的大规模可视化研究
Rebecca Andrews,Bin Fu,Christina E Toomey et al.
Rebecca Andrews et al.
Parkinson's disease (PD) is a neurodegenerative condition characterized by the presence of intraneuronal aggregates containing fibrillar ɑ-synuclein known as Lewy bodies. These large end-stage species are formed by smaller soluble protein ...
Brain-heart-eye axis revealed by multi-organ imaging genetics and proteomics [0.03%]
多器官影像遗传学和蛋白质组学揭示脑心眼轴规律
MULTI Consortium;Aleix Boquet-Pujadas,Filippos Anagnostakis,Michael R Duggan et al.
MULTI Consortium;Aleix Boquet-Pujadas et al.
Multi-organ research investigates interconnections among multiple human organ systems, enhancing our understanding of human aging and disease mechanisms. Here we use multi-organ imaging, individual- and summary-level genetics, and proteomic...