Engineering a macromolecular JAK inhibitor for treating acute inflammation and endotoxaemia [0.03%]
工程化的大分子JAK抑制剂在急性炎症和内毒素血症治疗中的应用
Min Zhou,Yan Wang,Bin Yang et al.
Min Zhou et al.
Uncontrolled and sustained inflammation is inextricably associated with the pathogenesis of numerous diseases. However, there is still demand for effective and safe anti-inflammatory therapies. Here we report a potent anti-inflammatory macr...
Deep-learning-based HER2 status assessment from multimodal breast cancer data predicts neoadjuvant therapy response [0.03%]
基于深度学习的HER2状态评估乳腺癌多模态数据可预测新辅助治疗反应
Jiadong Zhang,Yonghao Li,Zheren Li et al.
Jiadong Zhang et al.
Accurate assessment of human epidermal growth factor receptor 2 (HER2) status is crucial for effective breast cancer treatment planning and improved patient outcomes. Traditional needle biopsies, limited in tissue sampling, often lead to in...
Inhibition of LARP4-mediated quiescence exit of naive CD4+ T cells ameliorates autoimmune and allergic diseases [0.03%]
抑制LARP4介导的初始CD4⁺T细胞静止退出可改善自身免疫和过敏性疾病
Jian Zhou,Di Yang,Chao Han et al.
Jian Zhou et al.
Naive T cells are maintained under a quiescent state, and their exit from quiescence is a hallmark of antigen stimulation. Here we identify the RNA binding protein La-related protein 4 (LARP4) as an important checkpoint regulator of quiesce...
Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level [0.03%]
靶向和追踪mRNA脂质纳米颗粒的颗粒、转录本及蛋白水平的方法
Diana D Kang,Adam Marks,Judit Morla-Folch et al.
Diana D Kang et al.
Lipid nanoparticles (LNPs) are a versatile platform with numerous experimental, diagnostic and therapeutic applications. However, the high propensity of LNPs to accumulate in hepatocytes and antigen-presenting cells has largely limited thei...
Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics [0.03%]
长效寡聚体通过在药物中诱导稳定RNA G-四链结构来抑制蛋白质合成
Yousuke Katsuda,Takuto Kamura,Tomoki Kida et al.
Yousuke Katsuda et al.
Gene-silencing mechanisms using RNA interference (RNAi) and antisense oligomers have drawn attention to nucleic acid medicines. However, several challenges remain such as low in vivo stability and inadequate target selectivity. Here we repo...
Tham T Nguyen,Patrick Ho,Sarah Staudt et al.
Tham T Nguyen et al.
Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in treating haematologic malignancies. However, the rise in clinical use has highlighted substantial challenges related to T cell- and tumour-intrinsic mechanism...
Large-scale generation of iNK and CAR-iNK cells from CD34+ haematopoietic stem and progenitor cells for adoptive immunotherapy [0.03%]
从CD34阳性造血干细胞和祖细胞中大规模生成iNK和CAR-iNK细胞用于过继免疫治疗
Fangxiao Hu,Jianhuan Li,Yao Wang et al.
Fangxiao Hu et al.
Chimaeric antigen receptor (CAR) natural killer (CAR-NK) cells are a promising alternative to CAR-T cells for immunotherapies. High and multiple doses of CAR-NK cell infusions are essential to maintain therapeutic efficacy in clinical trial...
Enzyme-converted O kidneys allow ABO-incompatible transplantation without hyperacute rejection in a human decedent model [0.03%]
酶转化O型肾脏允许ABO不符供肾在人类受试者模型中进行移植且不会产生超急性排斥反应
Jun Zeng,Ming Ma,Ze Tao et al.
Jun Zeng et al.
ABO-incompatible kidney transplantation is widely used to meet the escalating need for organs. Current recipient-centric desensitization protocols involving antibody depletion through plasmapheresis increase the risk of infections, perioper...