3D foundation model for generalizable disease detection in head computed tomography [0.03%]
头颅CT通用疾病筛查的三维基础模型
Weicheng Zhu,Haoxu Huang,Huanze Tang et al.
Weicheng Zhu et al.
Head computed tomography (CT) imaging is a widely used imaging modality with multitudes of medical indications, particularly in assessing pathology of the brain, skull and cerebrovascular system. It is commonly used as the first-line imagin...
Theoretical quantitative model and clinical outcome predictions of conductive cardiac patches for electrophysiological treatments [0.03%]
传导性心脏补片的理论定量模型及电生理治疗预后预测
Yuchen Miao,Zhenyin Fu,Juhong Zhang et al.
Yuchen Miao et al.
Myocardial infarction (MI) impairs cardiac electrical signal transmission, which could be partially remedied by implantable electroactive biomaterials. Here we characterize electroactive cardiac patches (eCarPs) with conductivities spanning...
Three-dimensional quantitative tissue clearing reveals differences in osteovascular niche of aged and young human mesenchymal stromal cells [0.03%]
三维定量组织清除技术揭示了年轻和老年人大肠系膜间充质干细胞骨血管生态位的差异
Nelson Tsz Long Chu,Ostap Dregval,Yu-Wei Chang et al.
Nelson Tsz Long Chu et al.
Human bone marrow mesenchymal stromal/stem cells (BM-MSCs) are widely used in clinical trials and tissue engineering, yet their native microenvironment remains poorly understood. Here we introduce a tissue-clearing protocol, DeepBone, for h...
Mammary organoid-based depot for post-surgical chemotherapy and gland regeneration [0.03%]
基于乳糜器官芯片的术后化疗和腺体再生药物释放装置
Shenqiang Wang,Yinxian Yang,Yanfang Wang et al.
Shenqiang Wang et al.
Preventing cancer recurrence after surgical removal, while preserving breast cosmesis and restoring function, remains challenging. Traditional scaffold-based approaches are often restricted by their inadequate integration with natural tissu...
Cristina C Barrias
Cristina C Barrias
In vivo base editing rescues liver pathophysiology and peroxisome dysfunction in a mouse model of Zellweger spectrum disorder [0.03%]
体内碱基编辑矫正生物模型中齐勒-格器综合征患者的肝病理生理异常和过氧化物酶体功能障碍
Xin D Gao,Maximiliano Presa,Jordyn E Duby et al.
Xin D Gao et al.
Zellweger spectrum disorder (ZSD) is caused by biallelic loss-of-function variants in PEX genes required for peroxisome biogenesis, which is critical for normal cellular metabolism and signalling. The PEX1-p.G843D (c.2528G>A) allele, presen...
Jun Wen,Sihang Zeng,Clara-Lea Bonzel et al.
Jun Wen et al.
Missense variants (MVs) influence clinical phenotypes, but our understanding of their phenotypic consequences remains constrained. Existing computational approaches to interpret MVs predominantly assess their pathogenicity, without consider...
Guo-Qing Fang,Yuan Deng,Xin-Yuan Lyu et al.
Guo-Qing Fang et al.
Prime editing (PE) enables precise genetic modifications using canonical prime editing guide RNA (pegRNA), with the reverse transcription template and primer binding site (RTT-PBS) attached to the 3' ends of CRISPR-Cas guide RNAs. Although ...
Haojun Yu,Youcheng Li,Nan Zhang et al.
Haojun Yu et al.
Foundation models have emerged as powerful tools for addressing various tasks in clinical settings. However, their potential development for breast ultrasound analysis remains untapped. Here we present BUSGen, the first foundation generativ...