Concurrent intratumoural Treg cell depletion and CD8+ T cell expansion via a cleavable anti-4-1BB-interleukin-15 fusion protein [0.03%]
一种可裂解的抗4-1BB-白细胞介素15融合蛋白通过同时耗尽瘤内调节性T细胞和扩增CD8⁺T细胞而起作用
Yueqi Cai,Zilong Han,Jiao Shen et al.
Yueqi Cai et al.
Potent agonists of the inducible co-stimulatory receptor 4-1BB are too toxic for patients with advanced cancer. Here, on the basis of observations of a weak agonist of 4-1BB depleting regulatory T (Treg) cells within the tumour microenviron...
Magnetic-susceptibility-dependent ratiometric probes for enhancing quantitative MRI [0.03%]
基于磁化率的比值型探针增强定量MRI检测性能
Cheng Zhang,Bin Nan,Juntao Xu et al.
Cheng Zhang et al.
In magnetic resonance imaging (MRI), quantitative measurements of analytes are hindered by difficulties in distinguishing the MRI signals of activation of the probe by the analyte from those of the accumulation of the intact probe. Here we ...
Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations [0.03%]
通过优化的脂质纳米颗粒配方传递的核糖核蛋白实现更安全高效的碱基编辑和先导编辑
Rafał Hołubowicz,Samuel W Du,Jiin Felgner et al.
Rafał Hołubowicz et al.
Delivering ribonucleoproteins (RNPs) for in vivo genome editing is safer than using viruses encoding for Cas9 and its respective guide RNA. However, transient RNP activity does not typically lead to optimal editing outcomes. Here we show th...
Diagnosis of early-stage bladder cancer via unprocessed urine samples at the point of care [0.03%]
基于未经处理的尿液样本在床旁诊断膀胱癌
Changjoon Keum,Haejin Yeom,Tae Il Noh et al.
Changjoon Keum et al.
Diagnostic kits for the optical detection of bladder cancer in urine can facilitate effective screening and surveillance. However, the heterogeneity of urine samples, owing to patients with bladder cancer often presenting with haematuria, i...
Antitumour vaccination via the targeted proteolysis of antigens isolated from tumour lysates [0.03%]
利用蛋白酶体降解肿瘤裂解产物中的抗原进行瘤苗免疫接种
Yu Zhao,Donghui Song,Zeyu Wang et al.
Yu Zhao et al.
The activation of cytotoxic T cells against tumour cells typically requires the cross-presentation, by antigen-presenting cells (and via major histocompatibility complex class I molecules), of an epitope derived from a tumour antigen. A cri...
Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses [0.03%]
抗生素介导的随机诱变和细胞因子表达的溶瘤病毒的选择
Reza Rezaei,Stephen Boulton,Mahsa Ahmadi et al.
Reza Rezaei et al.
Optimization of oncolytic viruses for therapeutic applications requires the strategic removal or mutagenesis of virulence genes alongside the insertion of transgenes that enhance viral replication, spread and immunogenicity. However, the co...
Himanshu Soni,E Antonio Chiocca,Joshua D Bernstock
Himanshu Soni
Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution [0.03%]
通过定向化学进化优化用于mRNA递送的离子型脂质的活性和生物降解性
Xuexiang Han,Mohamad-Gabriel Alameh,Ying Xu et al.
Xuexiang Han et al.
Ionizable lipids largely determine the biocompatibility of lipid nanoparticles (LNPs) and the efficacy for mRNA delivery. Rational design and combinatorial synthesis have led to the development of potent and biodegradable ionizable lipids, ...
Solvent-mediated analgesia via the suppression of water permeation through TRPV1 ion channels [0.03%]
溶剂介导的镇痛作用通过抑制TRPV1离子通道的水分渗透实现
Yuxia Liu,Yuanyuan He,Jiahuan Tong et al.
Yuxia Liu et al.
Activation of the ion channel transient receptor potential vanilloid 1 (TRPV1), which is integral to pain perception, leads to an expansion of channel width, facilitating the passage of cations and large organic molecules. However, the perm...