Yuewen Zhai,Siwen Li
Yuewen Zhai
Potent prophylactic cancer vaccines harnessing surface antigens shared by tumour cells and induced pluripotent stem cells [0.03%]
利用肿瘤细胞和诱导多能干细胞共有的表面抗原的高效癌症预防性疫苗
Nan Li,Hao Qin,Fei Zhu et al.
Nan Li et al.
The development of prophylactic cancer vaccines typically involves the selection of combinations of tumour-associated antigens, tumour-specific antigens and neoantigens. Here we show that membranes from induced pluripotent stem cells can se...
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation [0.03%]
慢性适应性深部脑刺激的皮层记录获取面临的挑战和机遇
Jeffrey Herron,Aura Kullmann,Timothy Denison et al.
Jeffrey Herron et al.
Deep brain stimulation (DBS), a proven treatment for movement disorders, also holds promise for the treatment of psychiatric and cognitive conditions. However, for DBS to be clinically effective, it may require DBS technology that can alter...
Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors [0.03%]
基于亮氨酸拉链的多受体CAR-T细胞免疫磁性分离纯化技术
Scott E James,Sophia Chen,Brandon D Ng et al.
Scott E James et al.
Resistance to chimaeric antigen receptor (CAR) T cell therapy develops through multiple mechanisms, most notably antigen loss and tumour-induced immune suppression. It has been suggested that T cells expressing multiple CARs may overcome th...
Jacob T Robinson,Sumner L Norman,Matthew R Angle et al.
Jacob T Robinson et al.
Valeria Caprettini
Valeria Caprettini
Francisco Carrillo-Perez,Marija Pizurica,Kathleen Marchal et al.
Francisco Carrillo-Perez et al.
Prediction of metabolic subphenotypes of type 2 diabetes via continuous glucose monitoring and machine learning [0.03%]
基于动态葡萄糖监测和机器学习预测2型糖尿病代谢亚表型
Ahmed A Metwally,Dalia Perelman,Heyjun Park et al.
Ahmed A Metwally et al.
The classification of type 2 diabetes and prediabetes does not consider heterogeneity in the pathophysiology of glucose dysregulation. Here we show that prediabetes is characterized by metabolic heterogeneity, and that metabolic subphenotyp...