Characterization of tumour heterogeneity through segmentation-free representation learning on multiplexed imaging data [0.03%]
通过多路成像数据上的无分割表示学习来表征肿瘤异质性
Jimin Tan,Hortense Le,Jiehui Deng et al.
Jimin Tan et al.
High-dimensional multiplexed imaging can reveal the spatial organization of tumour tissues at the molecular level. However, owing to the scale and information complexity of the imaging data, it is challenging to discover and thoroughly char...
Nitroglycerin-responsive gene switch for the on-demand production of therapeutic proteins [0.03%]
硝酸甘油响应基因开关用于按需生产治疗蛋白
Mohamed Mahameed,Shuai Xue,Benjamin Danuser et al.
Mohamed Mahameed et al.
Gene therapies and cell therapies require precise, reversible and patient-friendly control over the production of therapeutic proteins. Here we present a fully human nitric-oxide-responsive gene-regulation system for the on-demand and local...
Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection [0.03%]
通过模拟异种移植排斥反应中抗原的加工和提呈过程来将疫苗针对树突状细胞
Jinjin Wang,Yuxuan Zhang,Yaru Jia et al.
Jinjin Wang et al.
Targeting the delivery of vaccines to dendritic cells (DCs) is challenging. Here we show that, by mimicking the fast and strong antigen processing and presentation that occurs during the rejection of xenotransplanted tissue, xenogeneic cell...
A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma [0.03%]
一种结合了人体粪便样本和蠕动功能的肠道芯片可以预测免疫检查点抑制剂治疗黑色素瘤的反应
Mattia Ballerini,Serena Galiè,Punit Tyagi et al.
Mattia Ballerini et al.
Patient responses to immune checkpoint inhibitors can be influenced by the gastrointestinal microbiome. Mouse models can be used to study microbiome-host crosstalk, yet their utility is constrained by substantial anatomical, functional, imm...
High-throughput multiplexed serology via the mass-spectrometric analysis of isotopically barcoded beads [0.03%]
基于同位素编码珠的质谱分析实现高通量多重化血清学检测
Alexandros P Drainas,David R McIlwain,Alec Dallas et al.
Alexandros P Drainas et al.
In serology, each sample is typically tested individually, one antigen at a time. This is costly and time consuming. Serology techniques should ideally allow recurrent measurements in parallel in small sample volumes and be inexpensive and ...
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array [0.03%]
通过微孔电极阵列并行膜内记录在数千个神经元之间绘制突触连接图谱
Jun Wang,Woo-Bin Jung,Rona S Gertner et al.
Jun Wang et al.
The massive parallelization of neuronal intracellular recording, which enables the measurement of synaptic signals across a neuronal network, and thus the mapping and characterization of synaptic connections, is an open challenge, with the ...
Yu Zhang,Xiang Liu,Tingting Shen et al.
Yu Zhang et al.
Messenger RNA vaccines have shown strong prophylactic efficacy against viral infections. Here we show that antigen-encoding small circular RNAs (circRNAs) loaded in lipid nanoparticles elicit potent and durable T cell responses for robust t...
Author Correction: A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens [0.03%]
作者更正：一种用于量化乳腺癌标本转移倾向的微流体测定法
Christopher L Yankaskas,Keyata N Thompson,Colin D Paul et al.
Christopher L Yankaskas et al.
Published Erratum
Nature biomedical engineering. 2025 Feb 5. DOI:10.1038/s41551-025-01359-y 2025
Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTENmRNA [0.03%]
作者更正：通过系统性纳米颗粒介导的体内传递PTENmRNA恢复肿瘤生长抑制
Mohammad Ariful Islam,Yingjie Xu,Wei Tao et al.
Mohammad Ariful Islam et al.
Published Erratum
Nature biomedical engineering. 2025 Feb 5. DOI:10.1038/s41551-025-01358-z 2025