A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths [0.03%]
用于通过DNA片段长度的分布密度定量循环肿瘤DNA的深度学习模型
Guanhua Zhu,Chowdhury Rafeed Rahman,Victor Getty et al.
Guanhua Zhu et al.
The quantification of circulating tumour DNA (ctDNA) in blood enables non-invasive surveillance of cancer progression. Here we show that a deep-learning model can accurately quantify ctDNA from the density distribution of cell-free DNA-frag...
Non-viral intron knock-ins for targeted gene integration into human T cells and for T-cell selection [0.03%]
用于人类T细胞靶向基因整合和T细胞选择的非病毒型内含子敲入技术
Theodore L Roth,Johnathan Lu,Alison McClellan et al.
Theodore L Roth et al.
Current methods for the precise integration of DNA sequences into the genome of human T cells predominantly target exonic regions, which limits the choice of integration site and requires complex cell-selection strategies. Here we show that...
Identifying perturbations that boost T-cell infiltration into tumours via counterfactual learning of their spatial proteomic profiles [0.03%]
通过反事实学习肿瘤空间蛋白质谱来识别促进T细胞浸润的扰动因素
Zitong Jerry Wang,Abdullah S Farooq,Yu-Jen Chen et al.
Zitong Jerry Wang et al.
Cancer progression can be slowed down or halted via the activation of either endogenous or engineered T cells and their infiltration of the tumour microenvironment. Here we describe a deep-learning model that uses large-scale spatial proteo...
A data-efficient strategy for building high-performing medical foundation models [0.03%]
构建高性能医学基础模型的数据高效策略
Yuqi Sun,Weimin Tan,Zhuoyao Gu et al.
Yuqi Sun et al.
Foundation models are pretrained on massive datasets. However, collecting medical datasets is expensive and time-consuming, and raises privacy concerns. Here we show that synthetic data generated via conditioning with disease labels can be ...
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2 [0.03%]
针对SARS-CoV-2奥密克戎变异选择治疗性抗体的深度突变学习方法研究
Lester Frei,Beichen Gao,Jiami Han et al.
Lester Frei et al.
Most antibodies for treating COVID-19 rely on binding the receptor-binding domain (RBD) of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). However, Omicron and its sub-lineages, as well as other heavily mutated variants, have ...
A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system [0.03%]
用于中枢神经系统氧化应激成像的正电子发射断层扫描示踪剂
Justin H Wilde,Yu-Yo Sun,Spenser R Simpson et al.
Justin H Wilde et al.
Reactive oxygen and nitrogen species (RONS) contribute to the pathogenesis of neurodegeneration, but the inability to detect RONS in vivo in the central nervous system has confounded the interpretation of results of clinical trials of antio...
3D-printed perfused models of the penis for the study of penile physiology and for restoring erectile function in rabbits and pigs [0.03%]
用于研究阴茎生理和恢复兔子及猪的勃起功能的3D打印灌流阴茎模型
Zhenxing Wang,Xuemin Liu,Tan Ye et al.
Zhenxing Wang et al.
The intricate topology of vascular networks and the complex functions of vessel-rich tissues are challenging to reconstruct in vitro. Here we report the development of: in vitro pathological models of erectile dysfunction and Peyronie's dis...
Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades [0.03%]
通过纳米粒子递送编码缓步动物中发现的损伤抑制蛋白的mRNA来保护健康组织免受辐射伤害
Ameya R Kirtane,Jianling Bi,Netra U Rajesh et al.
Ameya R Kirtane et al.
Patients undergoing radiation therapy experience debilitating side effects because of toxicity arising from radiation-induced DNA strand breaks in normal peritumoural cells. Here, inspired by the ability of tardigrades to resist extreme rad...
Enhancing phage therapy by coating single bacteriophage-infected bacteria with polymer to preserve phage vitality [0.03%]
通过用聚合物涂层包裹单一噬菌体感染细菌来维持噬菌体活力以增强噬菌体疗法
Sisi Lin,Guocheng Xie,Jun He et al.
Sisi Lin et al.
The efficacy of bacteriophages in treating bacterial infections largely depends on the phages' vitality, which is impaired when they are naturally released from their hosts, as well as by culture media, manufacturing processes and other ins...
Jing Liu,Penghui Cheng,Cheng Xu et al.
Jing Liu et al.
Advancing the understanding of the various roles and components of the immune system requires sophisticated methods and technology for the detection of immune cells in their natural states. Recent advancements in the development of molecula...