An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains [0.03%]
一种可植入的水凝胶基声子晶体，用于连续无线监测组织内部应变
Ye Tian,Yueying Yang,Hanchuan Tang et al.
Ye Tian et al.
Conventional implantable electronic sensors for continuous monitoring of internal tissue strains are yet to match the biomechanics of tissues while maintaining biodegradability, biocompatibility and wireless monitoring capability. Here we p...
Author Correction: Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds [0.03%]
作者更正：在组织特异性脱细胞支架上培养结直肠癌细胞获得器官特异性转移灶
Xi Tian,Michael E Werner,Kyle C Roche et al.
Xi Tian et al.
Published Erratum
Nature biomedical engineering. 2025 Apr 9. DOI:10.1038/s41551-025-01383-y 2025
Site-directed multivalent conjugation of antibodies to ubiquitinated payloads [0.03%]
定点多位点抗体连接以泛素化分子为负载的药物研究
Angela F El Hebieshy,Zacharias Wijfjes,Camille M Le Gall et al.
Angela F El Hebieshy et al.
Antibody conjugates are the foundation of a wide range of diagnostic and therapeutic applications. Although many antibody-conjugation techniques are robust and efficient, obtaining homogeneous multimeric conjugation products remains challen...
Bin Sheng,Pearse A Keane,Yih-Chung Tham et al.
Bin Sheng et al.
Michael Moritz,Eric Topol,Pranav Rajpurkar
Michael Moritz
Generation of tolerogenic antigen-presenting cells in vivo via the delivery of mRNA encoding PDL1 within lipid nanoparticles [0.03%]
通过脂质纳米颗粒递送编码PDL1的mRNA体内生成耐受性抗原呈递细胞
Yang Liu,Qian Liu,Baowen Zhang et al.
Yang Liu et al.
Tolerogenic antigen-presenting cells (APCs) are promising as therapeutics for suppressing T cell activation in autoimmune diseases. However, the isolation and ex vivo manipulation of autologous APCs is costly, and the process is customized ...
Michelle F Griffin,Jennifer B Parker,Ruth Tevlin et al.
Michelle F Griffin et al.
The inflammatory process resulting in the fibrotic encapsulation of implants has been well studied. However, how acellular dermal matrix (ADM) used in breast reconstruction elicits an attenuated foreign-body response (FBR) remains unclear. ...
Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering [0.03%]
用于多重基因组编辑、疾病建模和免疫细胞工程的Cas12a敲入小鼠
Kaiyuan Tang,Liqun Zhou,Xiaolong Tian et al.
Kaiyuan Tang et al.
The pleiotropic effects of human disease and the complex nature of gene-interaction networks require knock-in mice allowing for multiplexed gene perturbations. Here we describe a series of knock-in mice with a C57BL/6 background and with th...