Collagen-binding IL-12-armoured STEAP1 CAR-T cells reduce toxicity and treat prostate cancer in mouse models [0.03%]
一种用于小鼠模型的胶原蛋白结合型IL-12装甲STEAP1 CART细胞可降低毒副作用并治疗前列腺癌
Koichi Sasaki,Vipul Bhatia,Yuta Asano et al.
Koichi Sasaki et al.
Immunosuppressive microenvironments, the lack of immune infiltration, and antigen heterogeneity pose challenges for chimaeric antigen receptor (CAR)-T cell therapies applied to solid tumours. Previously, CAR-T cells were armoured with immun...
Targeting immunosuppressive myeloid cells via implant-mediated slow release of small molecules to prevent glioblastoma recurrence [0.03%]
通过植入物介导缓慢释放小分子靶向免疫抑制性髓系细胞以预防胶质母细胞瘤复发
Yannik Kaiser,Christopher S Garris,Eliana Marinari et al.
Yannik Kaiser et al.
Glioblastoma is a highly aggressive brain tumour with a high risk of recurrence after surgery, even when combined with chemotherapy and radiotherapy. A major barrier to lasting treatment is the tumour's immunosuppressive environment, which ...
A HO-1 gene knockout using a NanoCRISPR scaffold suppresses metastasis in mouse models [0.03%]
基于NanoCRISPR支架的HO-1基因敲除抑制小鼠模型转移效果研究
Ning Wang,Zichao Luo,Chao Liu et al.
Ning Wang et al.
Photodynamic therapy-induced immunogenic cell death has the potential to generate autologous cancer vaccines. However, the innate or evolved genetic tolerance of tumours limits the efficacy of this approach. Here we report the development o...
Maya Ezzo,Boris Hinz
Maya Ezzo
Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis [0.03%]
靶向循环力响应性单核细胞和巨噬细胞以减少纤维化
Kellen Chen,Michelle Griffin,Dominic Henn et al.
Kellen Chen et al.
In response to injury, a variety of different cells are recruited to sites of injury to facilitate healing. Recent studies have examined the importance of the heterogeneity of tissue resident fibroblasts and mechanical signalling pathways i...
CCR5-targeted allogeneic gamma-delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy [0.03%]
用于HIV相关B细胞恶性肿瘤免疫治疗的CCR5靶向同种异体γδCD19嵌合抗原受体T细胞
Ángel Ramírez-Fernández,Alexander J Dimitri,Fang Chen et al.
Ángel Ramírez-Fernández et al.
Immune-based cell therapy offers a promising approach to cancer treatment. While autologous chimeric antigen receptor (CAR) T cells have shown success, production is time-consuming, costly and patient specific. Gamma-delta (γδ) T cells ar...
Sadra Bakhshandeh
Sadra Bakhshandeh
Rita Strack
Rita Strack
Michael Attwaters
Michael Attwaters