Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations [0.03%]
聚焦超声-微泡治疗可阻止脑海绵状血管瘤的发生与发展
Delaney G Fisher,Tanya Cruz,Matthew R Hoch et al.
Delaney G Fisher et al.
Cerebral cavernous malformations (CCMs) are vascular lesions within the central nervous system that cause debilitating neurological symptoms. Currently, surgical excision and stereotactic radiosurgery, the primary treatment options, pose ri...
Soraia Fernandes,Francesca Cavalieri
Soraia Fernandes
Enhanced nanoparticle delivery across vascular basement membranes of tumours using nitric oxide [0.03%]
利用一氧化氮技术增强纳米颗粒透过肿瘤血管基底膜效应
Wei Jiang,Zixuan Guo,Qin Wang et al.
Wei Jiang et al.
The delivery of nanoparticles (NPs) into solid tumours is challenged by the tumour vascular basement membrane (BM), a critical barrier beneath the endothelium with robust mechanical properties resistant to conventional treatments. Here we p...
A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide [0.03%]
一种光控型二苯丙氨酸衍生物广谱抗菌肽
Xiaoguang Zhang,Xiaobo Feng,Liang Ma et al.
Xiaoguang Zhang et al.
The antimicrobial effect of antimicrobial peptides is typically slow; they can be rapidly biodegraded and often have non-selective toxicity and elaborate sequences. Here we report a short peptide that is activated by ultrasound, that shows ...
Magnetically driven biohybrid blood hydrogel fibres for personalized intracranial tumour therapy under fluoroscopic tracking [0.03%]
磁控生物杂化血液水凝胶纤维：颅内肿瘤治疗的个性化方案及荧光透视追踪技术
Ben Wang,Jie Shen,Chenyang Huang et al.
Ben Wang et al.
Small materials with pliability and untethered mobility are particularly suitable for minimally invasive medical interventions inside the body. However, the capabilities and applicability of such soft 'robots' are restricted by foreign-body...
A live bacteria enzyme assay for identification of human disease mutations and drug screening [0.03%]
用于识别人类疾病突变和药物筛选的活细菌酶检测方法
Donghui Choe,Bernhard O Palsson
Donghui Choe
Advances in high-throughput sequencing have enabled the identification of genetic variations associated with human disease. However, deciphering the functional significance of these variations remains challenging. Here we propose an alterna...
A highly mobile adeno-associated virus targeting vascular smooth muscle cells for the treatment of pulmonary arterial hypertension [0.03%]
一种高度移动的腺相关病毒靶向血管平滑肌细胞以治疗肺动脉高压
Yoojin Kim,Yeongju Yeo,Minju Kim et al.
Yoojin Kim et al.
In pulmonary arterial hypertension (PAH), a phenotypic switch in pulmonary arterial smooth muscle cells (PASMCs) that is primarily caused by aberrant gene regulatory networks can lead to dysregulated vascular remodelling, heart failure or d...
High-resolution prosthetic hearing with a soft auditory brainstem implant in macaques [0.03%]
一种柔软的听觉脑干植入物在恒河猴中的高保真仿生听力研究
Alix Trouillet,Emilie Revol,Florent-Valéry Coen et al.
Alix Trouillet et al.
Individuals with compromised cochlear nerves are ineligible for cochlear implants and instead rely on auditory brainstem implants (ABIs). Most users of ABIs experience sound awareness, which aids in lip reading, yet not speech intelligibili...
Author Correction: Viscoelastic synthetic antigen-presenting cells for augmenting the potency of cancer therapies [0.03%]
作者更正：用于增强癌症治疗效力的粘弹性的合成抗原呈递细胞
Zeyang Liu,Yan-Ruide Li,Youcheng Yang et al.
Zeyang Liu et al.
Published Erratum
Nature biomedical engineering. 2025 Apr 15. DOI:10.1038/s41551-025-01386-9 2025
Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology [0.03%]
水和离子与细胞外基质结合导致的应力松弛有助于磁共振成像检测肿胀相关病变
Matthias R Kollert,Martin Krämer,Nicholas M Brisson et al.
Matthias R Kollert et al.
Swelling-associated changes in extracellular matrix (ECM) occur in many pathological conditions involving inflammation or oedema. Here we show that alterations in the proportion of loosely bound water in ECM correlate with changes in ECM el...