A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans [0.03%]
一种无线设备可连续测量脑实质阻力以追踪人类glymphatic功能
Paul Dagum,Laurent Giovangrandi,Swati Rane Levendovszky et al.
Paul Dagum et al.
Glymphatic function in animal models supports the clearance of brain proteins whose mis-aggregation is implicated in neurodegenerative conditions including Alzheimer's and Parkinson's disease. The measurement of glymphatic function in the h...
Tension-induced directional migration of hepatic stellate cells potentially coordinates liver fibrosis progression [0.03%]
张力诱导的肝星状细胞定向迁移可能协调肝脏纤维化进展
Lyu Zhou,Ziao Shi,Xuesi Yang et al.
Lyu Zhou et al.
Liver fibrosis is an over-reacted wound healing that becomes lethal in its late stage, when hepatic stellate cells (HSCs) trigger fibrotic response, proliferation of connective tissue and build-up of directional fibrous tissue bands (septa)...
Yihang Chen,Kaiyu X Fu,Renee Cotton et al.
Yihang Chen et al.
The development of biosensors that can detect specific analytes continuously, in vivo, in real time has proven difficult due to biofouling, probe degradation and signal drift that often occur in vivo. By drawing inspiration from intestinal ...
High-throughput single-cell density measurements enable dynamic profiling of immune cell and drug response from patient samples [0.03%]
高通量单细胞密度测定能够从患者样本中动态分析免疫细胞和药物反应
Weida Wu,Sarah H Ishamuddin,Thomas W Quinn et al.
Weida Wu et al.
Cell density, the ratio of cell mass to volume, is an indicator of molecular crowding and a fundamental determinant of cell state and function. However, existing density measurements lack the precision or throughput to quantify subtle diffe...
Treatment of a metabolic liver disease in mice with a transient prime editing approach [0.03%]
使用瞬时prime编辑方法治疗小鼠代谢性肝病
Tanja Rothgangl,András Tálas,Eleonora I Ioannidi et al.
Tanja Rothgangl et al.
Prime editing is a versatile genome editing technology that circumvents the need for DNA double-strand break formation and homology-directed repair, making it particularly suitable for in vivo correction of pathogenic mutations. Here we dev...
Long-term engraftment of human stem and progenitor cells for large-scale production of functional immune cells in engineered pigs [0.03%]
人干细胞和祖细胞在基因工程猪体内的长期植入及功能性免疫细胞的大规模生产
Zheng Hu,Jun Zou,Zhengzhu Wang et al.
Zheng Hu et al.
Existing immunodeficient pig models have demonstrated limited success in supporting robust human haematopoietic engraftment and multilineage differentiation. Here we hypothesize that the targeted deletion of integrin-associated protein (Cd4...
siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs [0.03%]
一种用于递送和治疗小鼠和 Guinea pig 关节炎的与白蛋白亲和力高且不易降解的 siRNA 偶联体
Juan M Colazo,Megan C Keech,Veeraj Shah et al.
Juan M Colazo et al.
Osteoarthritis and rheumatoid arthritis are debilitating joint diseases marked by pain, inflammation and cartilage destruction. Current osteoarthritis treatments only relieve symptoms, while rheumatoid arthritis therapies can cause immune s...
Yi-Xian Qin,Elias Georgas
Yi-Xian Qin
A compact, wireless system for continuous monitoring of breast milk expressed during breastfeeding [0.03%]
一种监测哺乳期间乳汁分泌的无线连续监测系统
Jihye Kim,Seyong Oh,Raudel Avila et al.
Jihye Kim et al.
Human milk is the ideal source of nutrition for infants. Most health organizations recommend direct breastfeeding from the first hour of life, extending throughout the first and second year. However, uncertainties regarding the volumes of m...
Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes [0.03%]
基于喹啉-丙二腈的探针活体脑淀粉样蛋白-β斑块的多重成像
Jianfeng Dai,Weijun Wei,Chenxu Yan et al.
Jianfeng Dai et al.
The dynamic behaviour of amyloid-β (Aβ) plaques in Alzheimer's disease remains poorly understood, and accumulation and distribution of Aβ plaques must be inferred from in vitro pathological changes in brain tissue. In situ detection of A...