Ultrafast J-resolved magnetic resonance spectroscopic imaging for high-resolution metabolic brain imaging [0.03%]
超快J解析磁共振光谱成像用于高分辨脑代谢成像
Yibo Zhao,Yudu Li,Wen Jin et al.
Yibo Zhao et al.
Magnetic resonance spectroscopic imaging has potential for non-invasive metabolic imaging of the human brain. Here we report a method that overcomes several long-standing technical barriers associated with clinical magnetic resonance spectr...
Isabelle Martinier,Laetitia de Kort,Petra de Graaf
Isabelle Martinier
A robust and scalable framework for hallucination detection in virtual tissue staining and digital pathology [0.03%]
一种用于虚拟组织染色和数字病理学中幻觉检测的稳健可扩展框架
Luzhe Huang,Yuzhu Li,Nir Pillar et al.
Luzhe Huang et al.
Histopathological staining of human tissue is essential for disease diagnosis. Recent advances in virtual tissue staining technologies using artificial intelligence alleviate some of the costly and tedious steps involved in traditional hist...
PET-based tracking of CAR T cells and viral gene transfer using a cell surface reporter that binds to lanthanide complexes [0.03%]
基于PET的CAR-T细胞追踪及利用结合镧系化合物的细胞表面报告基因的病毒介导的基因转移技术
Volker Morath,Katja Fritschle,Linda Warmuth et al.
Volker Morath et al.
The clinical translation of cell- and gene-based therapies is limited by the lack of non-invasive, quantitative and specific whole-body imaging tools. Here we present a positron emission tomography reporter system based on a membrane-anchor...
Macrophage-augmented organoids recapitulate the complex pathophysiology of viral diseases and enable development of multitarget therapeutics [0.03%]
巨噬细胞增强型类器官可再现病毒性疾病复杂的病理生理状态并促进多靶标药物研发
Kuan Liu,Yining Wang,Jiajing Li et al.
Kuan Liu et al.
The pathophysiology of acute viral diseases is complex. It is characterized by strong inflammatory responses driven by immune cells, leading to tissue damage. Currently available in vitro models mainly recapitulate the viral life cycle but ...
Christopher K Tuggle,Crystal L Loving,Beau R Webber
Christopher K Tuggle
Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody-STING agonist conjugates [0.03%]
利用模块化白蛋白顺势药物纳米抗体-STING激动剂缀合物增强癌症免疫治疗
Blaise R Kimmel,Karan Arora,Neil C Chada et al.
Blaise R Kimmel et al.
The enhancement of antitumour immunity via agonists of the stimulator of interferon genes (STING) pathway is limited by pharmacological barriers. Here we show that the covalent conjugation of a STING agonist to anti-albumin nanobodies via s...
Shuyue Ye,Jinming Gao
Shuyue Ye
A deep learning system for detecting silent brain infarction and predicting stroke risk [0.03%]
一种用于检测无症状脑梗塞和预测卒中风险的深度学习系统
Nan Jiang,Hongwei Ji,Zhouyu Guan et al.
Nan Jiang et al.
Current brain imaging to detect silent brain infarctions (SBIs) is not feasible for the general population. Here, to overcome this challenge, we developed a retinal image-based deep learning system, DeepRETStroke, to detect SBI and refine s...
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders [0.03%]
神经影像内表型揭示四种脑疾病进展和发展背后的潜在机制和遗传因素
Junhao Wen,Ioanna Skampardoni,Ye Ella Tian et al.
Junhao Wen et al.
Recent work leveraging artificial intelligence has offered promise to dissect disease heterogeneity by identifying complex intermediate brain phenotypes, called dimensional neuroimaging endophenotypes (DNEs). We advance the argument that th...