Movement-responsive deep brain stimulation for Parkinson's disease using a remotely optimized neural decoder [0.03%]
用于帕金森病的运动反应性深部脑刺激，使用远程优化神经解码器
Tanner C Dixon,Gabrielle Strandquist,Alicia Zeng et al.
Tanner C Dixon et al.
Deep brain stimulation (DBS) has garnered widespread use as an effective treatment for advanced Parkinson's disease. Conventional DBS (cDBS) provides electrical stimulation to the basal ganglia at fixed amplitude and frequency, yet patients...
Self-powered rapid antigen-specific T-cell response assay for Mycobacterium tuberculosis infections [0.03%]
用于结核分枝杆菌感染的自供电快速抗原特异性T细胞反应测定法
Bo Ning,Sutapa Chandra,Yongchun Pan et al.
Bo Ning et al.
Interferon-gamma release assays (IGRAs) that evaluate an individual's T-cell activation response to Mycobacterium tuberculosis (M.tb)-specific peptides serve an important role in diagnosing tuberculosis (TB). However, there are substantial ...
Discovery of high-affinity ligands for prostatic acid phosphatase via DNA-encoded library screening enables targeted cancer therapy [0.03%]
通过DNA编码库筛选发现前列腺酸性磷酸酶的高亲和力配体实现靶向癌症治疗
Tony Georgiev,Francesca Migliorini,Andrea Ciamarone et al.
Tony Georgiev et al.
Improving the specificity of prostate cancer treatment requires ligands that bind selectively and with ultra-high affinity to tumour-associated targets absent from healthy tissues. Prostatic acid phosphatase has emerged as an alternative ta...
Ya-Nan Fan,Long Zhu,Yu-Xin Qing et al.
Ya-Nan Fan et al.
Immobilizing multiple types of monoclonal antibody (mAb) on nanoparticle surfaces is a promising approach for creating nanomedicines that emulate the functionality of multi-specific antibodies. However, the clinical translation of these mul...
Self-organization of sinusoidal vessels in pluripotent stem cell-derived human liver bud organoids [0.03%]
人肝芽器官组织中多能干细胞衍生的窦状血管的自我组织生成
Norikazu Saiki,Yasunori Nio,Yosuke Yoneyama et al.
Norikazu Saiki et al.
The induction of tissue-specific vessels in in vitro living tissue systems remains challenging. Here, we directly differentiated human pluripotent stem cells into CD32b+ putative liver sinusoidal progenitors by dictating developmental pathw...
Panoramic photoacoustic computed tomography with learning-based classification enhances breast lesion characterization [0.03%]
基于学习的分类全景式光声计算断层扫描技术增强乳腺病变特征分析
Xin Tong,Cindy Z Liu,Yilin Luo et al.
Xin Tong et al.
Breast cancer diagnosis is crucial due to the high prevalence and mortality rate associated with the disease. However, mammography involves ionizing radiation and has compromised sensitivity in radiographically dense breasts, ultrasonograph...
Strategies for the vascular patterning of engineered tissues for organ repair [0.03%]
组织工程血管图案化策略用于器官修复
Kevin D Janson,Siavash Parkhideh,Joseph W R Swain et al.
Kevin D Janson et al.
The loss of organ function following traumatic injury is often irreversible and the demand for organ replacements continues to exceed supply. This discrepancy has driven the development of therapies and engineered tissues for the repair or ...
Georgios Soultanidis,Joaquin L Herraiz,Zahi A Fayad et al.
Georgios Soultanidis et al.
Nuclear imaging provides non-invasive and near-quantitative insight into the biodistribution of radiolabelled compounds, and it does so with exceptional sensitivity and practically unlimited penetration depth. These properties make nuclear ...
A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases [0.03%]
一种用于解密复杂疾病中细胞动态和计算机药物发现的深度生成模型
Yumin Zheng,Jonas C Schupp,Taylor Adams et al.
Yumin Zheng et al.
Human diseases are characterized by intricate cellular dynamics. Single-cell transcriptomics provides critical insights, yet a persistent gap remains in computational tools for detailed disease progression analysis and targeted in silico dr...
LbuCas13a directly targets DNA and elicits strong trans-cleavage activity [0.03%]
LbuCas13A直接切割DNA并具有较强的转录cleavage活性
Xiaolong Wu,Siyuan Luo,Chuanghao Guo et al.
Xiaolong Wu et al.
Traditionally perceived as an RNA-specific nuclease, Cas13a has been used primarily for RNA detection. We discover the ability of Leptotrichia buccalis Cas13a (LbuCas13a) to directly target DNA without the restrictions of protospacer flanki...