Enantiomer-dependent and modification-free DNA matrix as an adjuvant for subunit vaccines against SARS-CoV-2 or pneumococcal infections [0.03%]
手性依赖且未经修饰的DNA基质作为对抗SARS-CoV-2或肺炎球菌感染的亚单位疫苗的佐剂
Cuifeng Li,Yuxin Li,Bini Zhou et al.
Cuifeng Li et al.
The emergence of novel infectious disease has intensified demand for more advanced vaccine development and more potent adjuvants to enhance immunogenicity. Here we introduce a dynamic DNA supramolecular matrix assembled from five unmodified...
Holographic transcranial ultrasound neuromodulation enhances stimulation efficacy by cooperatively recruiting distributed brain circuits [0.03%]
holographic经颅超声神经调控通过协同募集分布式脑网络来增强刺激效果
Hector Estrada,Yiming Chen,Théo Lemaire et al.
Hector Estrada et al.
Precision-targeted ultrasonic neuromodulation offers immense potential for studying brain function and treating neurological diseases. Yet, its application has been limited by challenges in achieving precise spatio-temporal control and moni...
Wenxiong Zhou,Li Kang,Shuo Qiao et al.
Wenxiong Zhou et al.
High-throughput sequencing technologies generate a vast number of DNA sequence reads simultaneously, which are subsequently analysed using the information contained within these fragmented reads. The assessment of sequencing technology reli...
Cancer biomarkers discovered using pan-cancer plasma proteomic profiling [0.03%]
泛癌种血浆蛋白组学鉴定出癌症生物标志物
Lin Bai,Jiacheng Lyu,Jinwen Feng et al.
Lin Bai et al.
Mass-spectrometry-based proteomic data of tumour patient plasma samples present opportunities for improving cancer detection. Here we generate plasma proteomic profiles from 2,251 pan-cancer patient samples and investigate potential diagnos...
Integration of chemical and physical inputs for monitoring metabolites and cardiac signals in diabetes [0.03%]
化学和物理输入在糖尿病代谢物和心脏信号监测中的整合
An-Yi Chang,Muyang Lin,Lu Yin et al.
An-Yi Chang et al.
The development of closed-loop systems towards effective management of diabetes requires the inclusion of additional chemical and physical inputs that affect disease pathophysiology and reflect cardiovascular risks in patients. Comprehensiv...
Souta Motoike,Yoshiko Inada,Junya Toguchida et al.
Souta Motoike et al.
Engineering jawbone tissues from pluripotent stem cells presents a challenge owing to the lack of protocols for selectively inducing the jawbone progenitor, the first pharyngeal arch (PA1) ectomesenchyme, and for recapitulating three-dimens...
Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T cell therapy for leukaemia [0.03%]
一种用于筛选治疗白血病的CAR-T细胞疗法的生物工程免疫完备临床前试验芯片工具
Chao Ma,Huishu Wang,Lunan Liu et al.
Chao Ma et al.
Chimeric antigen receptor (CAR) T cell immunotherapy is promising for treatment of blood cancers; however, clinical benefits remain unpredictable, necessitating development of optimal CAR T cell products. Unfortunately, current preclinical ...
Scalable production of human cortical organoids using a biocompatible polymer [0.03%]
使用生物相容性聚合物可扩展生产人类皮层类器官
Genta Narazaki,Yuki Miura,Sergey D Pavlov et al.
Genta Narazaki et al.
The generation of neural organoids from human pluripotent stem cells holds great promise in modelling disease and screening drugs, but current approaches are difficult to scale due to undesired organoid fusion. Here we develop a scalable ce...
Extension of replicative lifespan by synthetic engineered telomerase RNA in patient induced pluripotent stem cells [0.03%]
患者诱导多能干细胞中通过合成工程化端粒酶RNA扩增复制寿命
Neha Nagpal,Suneet Agarwal
Neha Nagpal
RNA engineering has yielded a new class of medicines but faces limitations depending on RNA size and function. Here we demonstrate the synthesis and enzymatic stabilization of telomerase RNA component (TERC), a therapeutically relevant long...
Jaime Ibáñez,Blanka Zicher,Etienne Burdet et al.
Jaime Ibáñez et al.
Accurate and robust recording and decoding from the central nervous system (CNS) is essential for advances in human-machine interfacing. Technologies for direct measurements of CNS activity are limited by their resolution, sensitivity to in...