Ping Wang,Yin-Shan Wang,Xi-Nian Zuo
Ping Wang
Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity [0.03%]
基于mannich反应的组合库识别抗氧化离子型脂质以递送mRNA并降低其免疫原性
Ningqiang Gong,Dongyoon Kim,Mohamad-Gabriel Alameh et al.
Ningqiang Gong et al.
The immunogenicity of lipid nanoparticles (LNPs) used for the delivery of nucleoside-modified messenger RNA limits the levels and durability of expression of the encoded protein. Here, by leveraging the Mannich reaction for ionizable lipid ...
Ultra-high gradient connectomics and microstructure MRI scanner for imaging of human brain circuits across scales [0.03%]
超高梯度连接组学和微结构磁共振扫描仪的人脑跨尺度成像研究
Gabriel Ramos-Llordén,Hong-Hsi Lee,Mathias Davids et al.
Gabriel Ramos-Llordén et al.
Defining the connectome, the complete matrix of structural connections between the nervous system nodes, is a challenge for human systems neuroscience due to the range of scales that must be bridged. Here we report the design of the Connect...
Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy [0.03%]
基于纳米抗体的双特异性抗体ENGAGERs靶向CTLA-4或PD-L1用于癌症免疫治疗
Xin Liu,Camille Le Gall,Ryan K Alexander et al.
Xin Liu et al.
As immune checkpoint blockade induces durable responses in only a subset of patients, more effective immunotherapies are needed. Here we present bispecific antibody engagers, fusion proteins composed of a nanobody that recognizes immunoglob...
Isogenic induced-pluripotent-stem-cell-derived airway- and alveolus-on-chip models reveal specific innate immune responses [0.03%]
同基因诱导多能干细胞衍生的气道和肺泡芯片模型揭示了特异的先天免疫反应
Sachin Yadav,Kazuya Fujimoto,Toru Takenaga et al.
Sachin Yadav et al.
The development of microphysiological systems for preclinical research is often hindered by the limited availability of reliable cell sources, especially when multiple organs or tissues from a single patient are needed for comparative studi...
A generative model uses healthy and diseased image pairs for pixel-level chest X-ray pathology localization [0.03%]
生成模型利用健康与患病的图像对进行像素级胸部X光片病理定位
Kaiming Dong,Yuxiao Cheng,Kunlun He et al.
Kaiming Dong et al.
Medical artificial intelligence (AI) offers potential for automatic pathological interpretation, but a practicable AI model demands both pixel-level accuracy and high explainability for diagnosis. The construction of such models relies on s...
Bispecific killer cell engager-secreting CAR-T cells redirect natural killer specificity to enhance antitumour responses [0.03%]
双特异杀伤细胞engage分泌型CAR-T细胞重定位自然杀伤细胞的特异性以增强抗肿瘤反应
Ya Fan,Yanting Duan,Jiangqing Chen et al.
Ya Fan et al.
T cells and natural killer (NK) cells collaborate to maintain immune homeostasis. Current cancer immunotherapies predominantly rely on the individual application of these cells. Here we use bicistronic vectors to co-express chimeric antigen...
A thermogalvanic cell dressing for smart wound monitoring and accelerated healing [0.03%]
一种用于智能伤口监测和加速愈合的热电细胞绷带
Jiwu Xin,Liheng Gao,Wenjie Zhang et al.
Jiwu Xin et al.
Current smart dressings with wound monitoring and electrical stimulation capabilities rely on flexible electronics comprising various sensors and external power sources. Despite increasing efforts to integrate all these components onto flex...
Label-free protein-structure-sensitive live-cell microscopy for patient-specific assessment of myeloma therapy [0.03%]
无标签、针对蛋白质结构的活细胞显微镜技术用于患者特异性评估多发性骨髓瘤治疗的效果
Francesca Gasparin,Marlene R Tietje,Eslam Katab et al.
Francesca Gasparin et al.
The efficacy of drug therapy in multiple myeloma is conventionally assessed by whole-cell-population methods, serum analysis of light chains and monoclonal antibodies, immunofixation electrophoresis, or by flow cytometry of bone marrow aspi...
Emergency delivery of particulate drugs by active ejection using in vivo wireless devices [0.03%]
利用体内无线设备主动喷射递送颗粒药物的紧急传输方法
Siddharth R Krishnan,Laura O&#x;Keeffe,Arnab Rudra et al.
Siddharth R Krishnan et al.
Rapidly administered emergency drug therapy represents life-saving treatment for a range of acute conditions including hypoglycaemia, anaphylaxis and cardiac arrest. Devices that automate emergency delivery, such as pumps and automated inje...