A self-adaptive and versatile tool for eliminating multiple undesirable variations from large-scale transcriptomes [0.03%]
一种自适应且多功能的工具，可从大规模转录组中消除多种不良变异
Mengji Zhang,Lei Yan,Xinbo Wang et al.
Mengji Zhang et al.
Accurate identification of true biological signals from diverse undesirable variations in large-scale transcriptomes is essential for downstream discoveries. Here we develop a universal deep neural network, called DeepAdapter, to eliminate ...
Harnessing electroencephalography connectomes for cognitive and clinical neuroscience [0.03%]
利用脑电连接组进行认知和临床神经科学研究
Yu Zhang,Zhe Sage Chen
Yu Zhang
Electroencephalography (EEG) connectomes offer powerful tools for studying brain connectivity and advancing our understanding of brain function and dysfunction in both healthy and pathological conditions. Celebrating the 100th anniversary o...
Publisher Correction: Ultra-high gradient connectomics and microstructure MRI scanner for imaging of human brain circuits across scales [0.03%]
出版更正：用于跨尺度人类大脑回路图谱的超高梯度连接组学和微观结构MRI扫描仪
Gabriel Ramos-Llordén,Hong-Hsi Lee,Mathias Davids et al.
Gabriel Ramos-Llordén et al.
Published Erratum
Nature biomedical engineering. 2025 Jul 22. DOI:10.1038/s41551-025-01484-8 2025
Floss-based vaccination targets the gingival sulcus for mucosal and systemic immunization [0.03%]
牙线基疫苗用于龈沟局部及全身免疫接种
Rohan S J Ingrole,Akhilesh Kumar Shakya,Gaurav Joshi et al.
Rohan S J Ingrole et al.
The oral cavity is an accessible site for vaccination, but its sublingual and buccal sites have limited vaccine uptake. Here we show that flat tape dental floss can deliver vaccines through the junctional epithelium of the gingival sulcus, ...
Jessica C Hsu,Jingwei Zhou,Weibo Cai
Jessica C Hsu
Precise virulence inactivation using a CRISPR-associated transposase for combating Enterobacteriaceae gut pathogens [0.03%]
利用CRISPR相关转座酶精确灭活肠杆菌科肠道病原菌的毒力基因
Carlotta Ronda,Tyler Perdue,Logan Schwanz et al.
Carlotta Ronda et al.
Targeted gene manipulation in a complex microbial community is an enabling technology for precise microbiome editing. Here we introduce BACTRINS, an in situ microbiome engineering platform designed for efficient and precise genomic insertio...
A pattern-learning algorithm associates copy number variations with brain structure and behavioural variables in an adolescent population cohort [0.03%]
一种模式学习算法将拷贝数变异与青少年群体的脑结构和行为变量联系起来
Jakub Kopal,Guillaume Huguet,Justin Marotta et al.
Jakub Kopal et al.
Our genetic makeup, together with environmental and social influences, shape our brain's development. Yet, the imaging-genetics field has struggled to integrate all these modalities to investigate the interplay between genetic blueprint, br...
Abdulkadir Sanli,Tinghao Hu,Leyang Li et al.
Abdulkadir Sanli et al.
Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading [0.03%]
通过增强早期I型干扰素反应来使肿瘤对免疫治疗敏感并促进表位扩散
Sadeem Qdaisat,Brandon Wummer,Brian D Stover et al.
Sadeem Qdaisat et al.
The success of cancer immunotherapies is predicated on the targeting of highly expressed neoepitopes, which preferentially favours malignancies with high mutational burden. Here we show that early responses by type-I interferons mediate the...