Mechanical regulation of extracellular vesicle activity during tumour progression [0.03%]
机械调节肿瘤进展期间的细胞外囊泡活性
Kshitiz Parihar,Di-Ao Liu,Ghmkin Hassan et al.
Kshitiz Parihar et al.
Extracellular vesicles (EVs) are naturally occurring membrane-bound vesicles secreted by cells. Functionalized with surface-targeting molecules and carrying signalling proteins and nucleic acids as cargo, EVs can rewire pathways and alter b...
Héctor Estrada,Thomas Deffieux,Justine Robin et al.
Héctor Estrada et al.
Optical and ultrasonic techniques for imaging the living brain have traditionally been limited to low-resolution interrogations or highly invasive craniotomy procedures. Localization-based techniques for super-resolution ultrasound and opti...
Tumour-resident oncolytic bacteria trigger potent anticancer effects through selective intratumoural thrombosis and necrosis [0.03%]
肿瘤居住的溶瘤细菌通过选择性肿瘤内血栓形成和细胞凋亡产生强大的抗癌症效果
Seigo Iwata,Taisei Nishiyama,Matomo Sakari et al.
Seigo Iwata et al.
Intratumoural bacteria represent a promising drug-free strategy in cancer therapy. Here we demonstrate that a tumour-resident bacterial consortium-Proteus mirabilis (A-gyo) and Rhodopseudomonas palustris (UN-gyo)-in a precise 3:97 ratio (A-...
Author Correction: Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity [0.03%]
作者更正：曼尼希反应基于的组合库识别抗氧化离子化脂质以递送mRNA并降低免疫原性
Ningqiang Gong,Dongyoon Kim,Mohamad-Gabriel Alameh et al.
Ningqiang Gong et al.
Published Erratum
Nature biomedical engineering. 2025 Jul 31. DOI:10.1038/s41551-025-01486-6 2025
Accelerating primer design for amplicon sequencing using large language model-powered agents [0.03%]
基于大型语言模型的代理加速扩增子测序primer设计
Yi Wang,Yuejie Hou,Lin Yang et al.
Yi Wang et al.
The pre-trained knowledge compressed in large language models is addressing diverse scientific challenges and catalysing the progression of autonomous laboratory systems, synergized with liquid handling robots. Here we introduce PrimeGen, a...
Yuanhao Qu,Kaixuan Huang,Ming Yin et al.
Yuanhao Qu et al.
Performing effective gene-editing experiments requires a deep understanding of both the CRISPR technology and the biological system involved. Meanwhile, despite their versatility and promise, large language models (LLMs) often lack domain-s...
Sergei Butenko,Maksim V Plikus
Sergei Butenko
Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy [0.03%]
利用功能性超声定位显微镜在小鼠脑中非侵入性表征周细胞功能障碍
Jérémy H Thalgott,Nicolas Zucker,Thomas Deffieux et al.
Jérémy H Thalgott et al.
Early microscopic-scale pericyte dysfunction contributes to the initial stages of many neurological diseases and represents a strong candidate target for therapeutic intervention. A non-invasive imaging modality able to image microvascular ...
Efficient and sustained optogenetic control of sensory and cardiac systems [0.03%]
高效而持续地控制感觉和心脏系统的光学遗传方法
Alexey Alekseev,Victoria Hunniford,Maria Zerche et al.
Alexey Alekseev et al.
Optogenetic control is used to manipulate the activity of specific cell types in vivo for a variety of biological and clinical applications. Here we report ChReef, an improved variant of the channelrhodopsin ChRmine. ChReef offers minimal p...
Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships [0.03%]
整合的体内组合功能基因组学和肿瘤空间转录组学解码基因型到表型的关系
Marco Breinig,Artem Lomakin,Elyas Heidari et al.
Marco Breinig et al.
Advancing spatially resolved in vivo functional genomes will link complex genetic alterations prevalent in cancer to critical disease phenotypes within tumour ecosystems. To this end, we developed PERTURB-CAST, a method to streamline the id...