Junhao Wen
Junhao Wen
Zakary S Singer,Jonathan Pabón,Hsinyen Huang et al.
Zakary S Singer et al.
The ability of bacteria and viruses to selectively replicate in tumours has led to synthetic engineering of new microbial therapies. Here we design a cooperative strategy whereby Salmonella typhimurium bacteria transcribe and deliver the Se...
GenomePAM directs PAM characterization and engineering of CRISPR-Cas nucleases using mammalian genome repeats [0.03%]
利用哺乳动物基因组重复序列表征和改造CRISPR-Cas核酸酶的PAM GenomePAM
Miao Yu,Limei Ai,Bang Wang et al.
Miao Yu et al.
Characterizing the protospacer adjacent motif (PAM) requirements of different Cas enzymes is a bottleneck in the discovery of Cas proteins and their engineered variants in mammalian cell contexts. Here, to overcome this challenge and to ena...
Author Correction: Small circular RNAs as vaccines for cancer immunotherapy [0.03%]
作者更正：作为癌症免疫疗法疫苗的小圆rna
Yu Zhang,Xiang Liu,Tingting Shen et al.
Yu Zhang et al.
Published Erratum
Nature biomedical engineering. 2025 Aug 12. DOI:10.1038/s41551-025-01490-w 2025
In vivo genome editing of human haematopoietic stem cells for treatment of blood disorders using mRNA delivery [0.03%]
使用mRNA递送对人类造血干细胞进行体内基因组编辑以治疗血液疾病
Saijuan Xu,Dan Liang,Qiudao Wang et al.
Saijuan Xu et al.
Ex vivo autologous haematopoietic stem cell (HSC) gene therapy provides a promising treatment option for haematological disorders. However, current methods involve complex processes and chemotherapeutic conditioning, leading to limited acce...
Publisher Correction: Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy [0.03%]
出版更正：使用功能超声定位显微镜对小鼠大脑周细胞功能障碍进行非侵入性表征
Jérémy H Thalgott,Nicolas Zucker,Thomas Deffieux et al.
Jérémy H Thalgott et al.
Published Erratum
Nature biomedical engineering. 2025 Aug 11. DOI:10.1038/s41551-025-01494-6 2025
Salman Ul Hassan Dar,Marvin Seyfarth,Isabelle Ayx et al.
Salman Ul Hassan Dar et al.
Generative artificial intelligence models facilitate open-data sharing by proposing synthetic data as surrogates of real patient data. Despite the promise for healthcare, some of these models are susceptible to patient data memorization, wh...
Continuous insulin monitoring using an antibody-protecting zwitterionic microneedle patch [0.03%]
使用两性离子微针贴片保护抗体进行连续胰岛素监测
Amin GhavamiNejad,Connor D Flynn,Armin Geraili et al.
Amin GhavamiNejad et al.
Continuous monitoring of protein and molecular biomarkers is essential for personalized disease tracking, but approaches for in vivo sensing are limited. Monitoring insulin, a peptide hormone, is an unmet need given the importance of this m...
Tethered optoacoustic and optical coherence tomography capsule endoscopy for label-free assessment of Barrett's oesophageal neoplasia [0.03%]
用于巴雷特食管肿瘤无标记评估的绳状光声和光学相干断层扫描胶囊内镜
Qian Li,Zakiullah Ali,Christian Zakian et al.
Qian Li et al.
Endoscopic detection of oesophageal cancer (EC) often occurs late in disease development, leading to high mortality rates. Improved technologies are urgently needed for earlier EC detection. Here we research an endoscopic ultra-broadband ac...
Thermoreversibly assembled polymersomes for highly efficient loading, processing and delivery of protein and siRNA biologics [0.03%]
用于蛋白质和siRNA生物制剂的高效装载、处理和输送的热可逆聚合物osomes
Samir Hossainy,Seounghun Kang,J Emiliano Gómez Medellín et al.
Samir Hossainy et al.
Versatile technologies that can deliver both RNA and protein payloads could streamline development, simplify manufacturing and expand the capabilities of combination therapies. Here we demonstrate an efficient approach to forming ca. 100 nm...