Fangyi Guan,Ningning Bai,Jia Song et al.
Fangyi Guan et al.
Plaque accumulation in coronary arteries causes stenoses, reducing blood flow and increasing the risk of cardiovascular disorders such as heart attacks. To assess the physiological impact of blood pressure across a stenosis, commercial pres...
A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modelling [0.03%]
一种用于脑内皮细胞基因传递和脑血管畸形建模的载体病毒
Jun-Liszt Li,Zhanying Bi,Xing-Jun Chen et al.
Jun-Liszt Li et al.
Defects in brain endothelial cells (brainECs) can cause severe cerebrovascular malformations, including arteriovenous malformation (AVM) and cerebral cavernous malformation. The lack of appropriate tools for cerebrovascular disease modellin...
Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs [0.03%]
利用杂交向导RNA提高体内腺嘌呤碱基编辑疗法的特异性和效率
Madelynn N Whittaker,Lauren C Testa,Aidan Quigley et al.
Madelynn N Whittaker et al.
Phenylketonuria (PKU), pseudoxanthoma elasticum (PXE) and hereditary tyrosinemia type 1 (HT1) are autosomal recessive disorders linked to the PAH, ABCC6, and FAH and HPD genes, respectively. Here we evaluate the off-target editing profiles ...
Computational design of synthetic receptors with programmable signalling activity for enhanced cancer T cell therapy [0.03%]
用于增强癌症T细胞疗法的可编程信号活性合成受体的计算设计
Jan A Rath,Lucas S P Rudden,Nazila Nouraee et al.
Jan A Rath et al.
The tumour microenvironment (TME) plays a key role in tumour progression, and soluble and cellular TME components can limit CAR-T cell function and persistence. Targeting soluble TME factors to enhance anti-tumour responses of engineered T ...
Author Correction: Peptide design through binding interface mimicry with PepMimic [0.03%]
作者更正：通过界面模拟进行肽设计（PepMimic）
Xiangzhe Kong,Rui Jiao,Haowei Lin et al.
Xiangzhe Kong et al.
Published Erratum
Nature biomedical engineering. 2025 Oct 27. DOI:10.1038/s41551-025-01570-x 2025
Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections [0.03%]
基于纳米抗体的组合疫苗利用许可蛋白纳米颗粒保护动物免受呼吸道和病毒感染
Tingting Li,Wenhui Xue,Sibo Zhang et al.
Tingting Li et al.
Combination vaccines promise to simplify immunization schedules and improve coverage, but remain technically challenging owing to antigen compatibility, immunogenic balance and formulation complexity. Here we report a modular strategy that ...
Liam C Kealy,Kim L Good-Jacobson
Liam C Kealy
Implanted microelectrode arrays in reinnervated muscles allow separation of neural drives from transferred polyfunctional nerves [0.03%]
植入微电极阵列可使移位的多功能神经元中的神经驱动相互分离
Laura Ferrante,Anna Boesendorfer,Deren Y Barsakcioglu et al.
Laura Ferrante et al.
Targeted muscle reinnervation surgery reroutes residual nerve signals into spare muscles, enabling the recovery of neural information through electromyography (EMG). However, EMG signals are often overlapping, making the interpretation of l...
Engineered thoracic spinal cord organoids for transplantation after spinal cord injury [0.03%]
脊髓损伤后的移植用工程胸脊髓器官簇
Yanjing Zhu,Ruiqi Huang,Liqun Yu et al.
Yanjing Zhu et al.
Stem-cell-based neural tissue engineering and spinal cord organoids show promises for spinal cord injury repair. However, the native spinal cord presents cell heterogeneity and a stereotypical spatial structure that makes difficult their re...
Comprehensive resistance profiling of chronic myeloid leukaemia associated ABL1 variants against five tyrosine kinase inhibitors using prime editing [0.03%]
利用基因编辑对慢性髓性白血病ABL1突变体进行五种激酶抑制剂的抗药性分析
Yusang Jung,Goosang Yu,Hyeong-Cheol Oh et al.
Yusang Jung et al.
There are four generations of tyrosine kinase inhibitors (TKIs) that target BCR-ABL1 mutations, a fusion oncogene, in chronic myeloid leukaemia, but predicting the resistance profiles of these TKIs for patients with ABL1 mutations is someti...