Combinatorial prediction of therapeutic perturbations using causally inspired neural networks [0.03%]
基于因果启发式神经网络的治疗扰动组合预测方法
Guadalupe Gonzalez,Xiang Lin,Isuru Herath et al.
Guadalupe Gonzalez et al.
Phenotype-driven approaches identify disease-counteracting compounds by analysing the phenotypic signatures that distinguish diseased from healthy states. Here we introduce PDGrapher, a causally inspired graph neural network model that pred...
A generalist foundation model and database for open-world medical image segmentation [0.03%]
通用基础模型和数据库用于开放世界的医学图像分割
Siqi Zhang,Qizhe Zhang,Shanghang Zhang et al.
Siqi Zhang et al.
Vision foundation models have demonstrated vast potential in achieving generalist medical segmentation capability, providing a versatile, task-agnostic solution through a single model. However, current generalist models involve simple pre-t...
Yuki Yamato,Jun Suzuki
Yuki Yamato
During the process of engulfment, phosphatidylserine is exposed on the surface of dead cells as an 'eat-me' signal and is recognized by Protein S (ProS), a secreted factor that also binds to the Mer tyrosine kinase (MerTK) on phagocytes. De...
A generalizable pathology foundation model using a unified knowledge distillation pretraining framework [0.03%]
一种使用统一知识蒸馏预训练框架的可泛化的病理基础模型
Jiabo Ma,Zhengrui Guo,Fengtao Zhou et al.
Jiabo Ma et al.
The generalization ability of foundation models in the field of computational pathology (CPath) is crucial for their clinical success. However, current foundation models have only been evaluated on a limited type and number of tasks, leavin...
Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis [0.03%]
流体剪切应力通过激活可靶向的机械-转移性级联促进髓母细胞瘤转移
Hyun-Kee Min,Hongyu Zhao,Alexander Bahcheli et al.
Hyun-Kee Min et al.
Biofluid flow generates fluid shear stress (FSS), a mechanical force widely present in the tissue microenvironment. How brain tumour growth alters the conduit of biofluid and impacts FSS-regulated cancer progression is unknown. Disseminatio...
Distributed battery-free bioelectronic implants with improved network power transfer efficiency via magnetoelectrics [0.03%]
基于磁电效应的分布式无电池生物电子植入器件及其高效的网络供能方法
Joshua E Woods,Fatima Alrashdan,Ellie C Chen et al.
Joshua E Woods et al.
Networks of miniature implants could enable simultaneous sensing and stimulation at different locations in the body, such as the heart and central or peripheral nervous system. This capability would support precise disease tracking and trea...
A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity [0.03%]
一种模块化疫苗平台，可优化脂质纳米颗粒mRNA的免疫原性
Zhenhao Fang,Valter S Monteiro,Changin Oh et al.
Zhenhao Fang et al.
Certain messenger RNA antigens in mRNA vaccines elicit an insufficient immune response due to challenges in cell surface translocation (CST) of the antigens. Here we develop a modular vaccine platform (MVP) to enhance the immunogenicity of ...
Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells [0.03%]
基于定向进化的靶向CAR-T细胞体内刺激的配体筛选方法
Tomasz M Grzywa,Alexandra Neeser,Ranjani Ramasubramanian et al.
Tomasz M Grzywa et al.
Chimeric antigen receptor (CAR) T cell therapy targeting CD19 elicits remarkable clinical efficacy in B cell malignancies, but many patients relapse owing to failed expansion and/or progressive loss of CAR-T cells. We recently reported a st...
Multiparametric cellular and spatial organization in cancer tissue lesions with a streamlined pipeline [0.03%]
具有精简管线的癌组织损伤中的多参数细胞和空间组织
Mark Buckup,Igor Figueiredo,Giorgio Ioannou et al.
Mark Buckup et al.
Multiplex immunostaining analysis remains fragmented, underperforming and labour intensive despite tissue proteomic methodologies achieving ever-increasing marker complexity. Here we propose an open-source, user-guided automated pipeline th...