Junwon Kang,Hamin Kim,Haewook Jang et al.
Junwon Kang et al.
Biopharmaceuticals are emerging as viable alternatives to chemically synthesized drugs for potential treatment to various diseases. However, many of these human-derived components cannot withstand terminal sterilization procedures, and the ...
Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery [0.03%]
工程化针对PD-L1的CAR-T细胞融合蛋白用于局部递送IL-12治疗实体瘤
John P Murad,Lea Christian,Reginaldo Rosa et al.
John P Murad et al.
Chimeric antigen receptor (CAR)-T cell efficacy in solid tumours is limited due in part to the immunosuppressive tumour microenvironment (TME). To improve antitumour responses, we hypothesized that enabling CAR-T cells to secrete bifunction...
Targeted clearance of extracellular Tau using aptamer-armed monocytes alleviates neuroinflammation in mice with Alzheimer's disease [0.03%]
靶向清除阿尔茨海默病模型小鼠中的Tau蛋白可减轻神经炎症
Yuting Zhuo,Yao Lu,Yan Zhu et al.
Yuting Zhuo et al.
Extracellular Tau determines the progression of Alzheimer's disease, yet therapeutic strategies targeting it are hindered by poor brain delivery and limited clearance. Here we developed a Tau-clearing cell therapy based on monocytes functio...
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue [0.03%]
帕金森病脑组织中寡聚α-突触核蛋白的大规模可视化研究
Rebecca Andrews,Bin Fu,Christina E Toomey et al.
Rebecca Andrews et al.
Parkinson's disease (PD) is a neurodegenerative condition characterized by the presence of intraneuronal aggregates containing fibrillar ɑ-synuclein known as Lewy bodies. These large end-stage species are formed by smaller soluble protein ...
Brain-heart-eye axis revealed by multi-organ imaging genetics and proteomics [0.03%]
多器官影像遗传学和蛋白质组学揭示脑心眼轴规律
MULTI Consortium;Aleix Boquet-Pujadas,Filippos Anagnostakis,Michael R Duggan et al.
MULTI Consortium;Aleix Boquet-Pujadas et al.
Multi-organ research investigates interconnections among multiple human organ systems, enhancing our understanding of human aging and disease mechanisms. Here we use multi-organ imaging, individual- and summary-level genetics, and proteomic...
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants [0.03%]
侵入式神经生理学和全脑连接组学在植入大脑装置的患者中的神经解码中的应用
Timon Merk,Richard M Köhler,Toni M Brotons et al.
Timon Merk et al.
Brain-computer interface research can inspire closed-loop neuromodulation therapies, promising spatiotemporal precision for the treatment of brain disorders. Decoding dynamic patient states from brain signals with machine learning is requir...
An artificial cilia-based array system for sound frequency decoding and resonance-responsive drug release [0.03%]
一种人工纤毛阵列系统用于声音频率解码和共振响应药物释放
Xinwei Wei,Hanlin Wang,Yanfang Wang et al.
Xinwei Wei et al.
Hair cells in the human ear contain cilia of varying lengths that sense varied acoustic signals. Here, inspired by this, we report an artificial cilia-based sound-decoding device capable of directly recognizing and responding to sound frequ...
An immune-competent lung-on-a-chip for modelling the human severe influenza infection response [0.03%]
一个用于模拟人类严重流感感染反应的免疫型肺芯片
Rachel Ringquist,Eshant Bhatia,Paramita Chatterjee et al.
Rachel Ringquist et al.
Severe influenza affects 3-5 million people worldwide each year, resulting in more than 300,000 deaths annually. However, standard-of-care antiviral therapeutics have limited effectiveness in these patients. Current preclinical models of se...
Hongjian Zhou,Fenglin Liu,Jinge Wu et al.
Hongjian Zhou et al.
Large language models (LLMs), such as ChatGPT, have substantially helped in understanding human inquiries and generating textual content with human-level fluency. However, directly using LLMs in healthcare applications faces several problem...
Author Correction: Cancer biomarkers discovered using pan-cancer plasma proteomic profiling [0.03%]
作者更正：使用全癌症血浆蛋白质组学分析发现癌症生物标志物
Lin Bai,Jiacheng Lyu,Jinwen Feng et al.
Lin Bai et al.
Published Erratum
Nature biomedical engineering. 2025 Sep 22. DOI:10.1038/s41551-025-01541-2 2025