Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics [0.03%]
长效寡聚体通过在药物中诱导稳定RNA G-四链结构来抑制蛋白质合成
Yousuke Katsuda,Takuto Kamura,Tomoki Kida et al.
Yousuke Katsuda et al.
Gene-silencing mechanisms using RNA interference (RNAi) and antisense oligomers have drawn attention to nucleic acid medicines. However, several challenges remain such as low in vivo stability and inadequate target selectivity. Here we repo...
Tham T Nguyen,Patrick Ho,Sarah Staudt et al.
Tham T Nguyen et al.
Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in treating haematologic malignancies. However, the rise in clinical use has highlighted substantial challenges related to T cell- and tumour-intrinsic mechanism...
Large-scale generation of iNK and CAR-iNK cells from CD34+ haematopoietic stem and progenitor cells for adoptive immunotherapy [0.03%]
从CD34阳性造血干细胞和祖细胞中大规模生成iNK和CAR-iNK细胞用于过继免疫治疗
Fangxiao Hu,Jianhuan Li,Yao Wang et al.
Fangxiao Hu et al.
Chimaeric antigen receptor (CAR) natural killer (CAR-NK) cells are a promising alternative to CAR-T cells for immunotherapies. High and multiple doses of CAR-NK cell infusions are essential to maintain therapeutic efficacy in clinical trial...
Enzyme-converted O kidneys allow ABO-incompatible transplantation without hyperacute rejection in a human decedent model [0.03%]
酶转化O型肾脏允许ABO不符供肾在人类受试者模型中进行移植且不会产生超急性排斥反应
Jun Zeng,Ming Ma,Ze Tao et al.
Jun Zeng et al.
ABO-incompatible kidney transplantation is widely used to meet the escalating need for organs. Current recipient-centric desensitization protocols involving antibody depletion through plasmapheresis increase the risk of infections, perioper...
Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation [0.03%]
一种用于多模态神经解码和刺激的可扩展高密度皮层微电极阵列的微创植入方法
Mark Hettick,Elton Ho,Adam J Poole et al.
Mark Hettick et al.
High-bandwidth brain-computer interfaces rely on invasive surgical procedures or brain-penetrating electrodes. Here we describe a cortical 1,024-channel thin-film microelectrode array and we demonstrate its minimally invasive surgical deliv...
Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation [0.03%]
用于多模式神经解码和刺激的可扩展高密度皮层微电极阵列的微创植入
Mark Hettick,Elton Ho,Adam J Poole et al.
Mark Hettick et al.
High-bandwidth brain-computer interfaces rely on invasive surgical procedures or brain-penetrating electrodes. Here we describe a cortical 1,024-channel thin-film microelectrode array and we demonstrate its minimally invasive surgical deliv...
Xiangzhe Kong,Rui Jiao,Haowei Lin et al.
Xiangzhe Kong et al.
Peptides offer advantages for targeted therapy, including oral bioavailability, cellular permeability and high specificity, setting them apart from conventional small molecules and biologics. Here we develop an artificial intelligence algor...
Benchmarking foundation models as feature extractors for weakly supervised computational pathology [0.03%]
基础模型作为弱监督计算病理学特征提取器的基准测试
Peter Neidlinger,Omar S M El Nahhas,Hannah Sophie Muti et al.
Peter Neidlinger et al.
Numerous pathology foundation models have been developed to extract clinically relevant information. There is currently limited literature independently evaluating these foundation models on external cohorts and clinically relevant tasks to...