CCR5-targeted allogeneic gamma-delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy [0.03%]
用于HIV相关B细胞恶性肿瘤免疫治疗的CCR5靶向同种异体γδCD19嵌合抗原受体T细胞
Ángel Ramírez-Fernández,Alexander J Dimitri,Fang Chen et al.
Ángel Ramírez-Fernández et al.
Immune-based cell therapy offers a promising approach to cancer treatment. While autologous chimeric antigen receptor (CAR) T cells have shown success, production is time-consuming, costly and patient specific. Gamma-delta (γδ) T cells ar...
Sadra Bakhshandeh
Sadra Bakhshandeh
Rita Strack
Rita Strack
Michael Attwaters
Michael Attwaters
Engineering a macromolecular JAK inhibitor for treating acute inflammation and endotoxaemia [0.03%]
工程化的大分子JAK抑制剂在急性炎症和内毒素血症治疗中的应用
Min Zhou,Yan Wang,Bin Yang et al.
Min Zhou et al.
Uncontrolled and sustained inflammation is inextricably associated with the pathogenesis of numerous diseases. However, there is still demand for effective and safe anti-inflammatory therapies. Here we report a potent anti-inflammatory macr...
Deep-learning-based HER2 status assessment from multimodal breast cancer data predicts neoadjuvant therapy response [0.03%]
基于深度学习的HER2状态评估乳腺癌多模态数据可预测新辅助治疗反应
Jiadong Zhang,Yonghao Li,Zheren Li et al.
Jiadong Zhang et al.
Accurate assessment of human epidermal growth factor receptor 2 (HER2) status is crucial for effective breast cancer treatment planning and improved patient outcomes. Traditional needle biopsies, limited in tissue sampling, often lead to in...
Inhibition of LARP4-mediated quiescence exit of naive CD4+ T cells ameliorates autoimmune and allergic diseases [0.03%]
抑制LARP4介导的初始CD4⁺T细胞静止退出可改善自身免疫和过敏性疾病
Jian Zhou,Di Yang,Chao Han et al.
Jian Zhou et al.
Naive T cells are maintained under a quiescent state, and their exit from quiescence is a hallmark of antigen stimulation. Here we identify the RNA binding protein La-related protein 4 (LARP4) as an important checkpoint regulator of quiesce...
Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level [0.03%]
靶向和追踪mRNA脂质纳米颗粒的颗粒、转录本及蛋白水平的方法
Diana D Kang,Adam Marks,Judit Morla-Folch et al.
Diana D Kang et al.
Lipid nanoparticles (LNPs) are a versatile platform with numerous experimental, diagnostic and therapeutic applications. However, the high propensity of LNPs to accumulate in hepatocytes and antigen-presenting cells has largely limited thei...