Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections [0.03%]
基于纳米抗体的组合疫苗利用许可蛋白纳米颗粒保护动物免受呼吸道和病毒感染
Tingting Li,Wenhui Xue,Sibo Zhang et al.
Tingting Li et al.
Combination vaccines promise to simplify immunization schedules and improve coverage, but remain technically challenging owing to antigen compatibility, immunogenic balance and formulation complexity. Here we report a modular strategy that ...
Liam C Kealy,Kim L Good-Jacobson
Liam C Kealy
Implanted microelectrode arrays in reinnervated muscles allow separation of neural drives from transferred polyfunctional nerves [0.03%]
植入微电极阵列可使移位的多功能神经元中的神经驱动相互分离
Laura Ferrante,Anna Boesendorfer,Deren Y Barsakcioglu et al.
Laura Ferrante et al.
Targeted muscle reinnervation surgery reroutes residual nerve signals into spare muscles, enabling the recovery of neural information through electromyography (EMG). However, EMG signals are often overlapping, making the interpretation of l...
Engineered thoracic spinal cord organoids for transplantation after spinal cord injury [0.03%]
脊髓损伤后的移植用工程胸脊髓器官簇
Yanjing Zhu,Ruiqi Huang,Liqun Yu et al.
Yanjing Zhu et al.
Stem-cell-based neural tissue engineering and spinal cord organoids show promises for spinal cord injury repair. However, the native spinal cord presents cell heterogeneity and a stereotypical spatial structure that makes difficult their re...
Comprehensive resistance profiling of chronic myeloid leukaemia associated ABL1 variants against five tyrosine kinase inhibitors using prime editing [0.03%]
利用基因编辑对慢性髓性白血病ABL1突变体进行五种激酶抑制剂的抗药性分析
Yusang Jung,Goosang Yu,Hyeong-Cheol Oh et al.
Yusang Jung et al.
There are four generations of tyrosine kinase inhibitors (TKIs) that target BCR-ABL1 mutations, a fusion oncogene, in chronic myeloid leukaemia, but predicting the resistance profiles of these TKIs for patients with ABL1 mutations is someti...
Collagen-binding IL-12-armoured STEAP1 CAR-T cells reduce toxicity and treat prostate cancer in mouse models [0.03%]
一种用于小鼠模型的胶原蛋白结合型IL-12装甲STEAP1 CART细胞可降低毒副作用并治疗前列腺癌
Koichi Sasaki,Vipul Bhatia,Yuta Asano et al.
Koichi Sasaki et al.
Immunosuppressive microenvironments, the lack of immune infiltration, and antigen heterogeneity pose challenges for chimaeric antigen receptor (CAR)-T cell therapies applied to solid tumours. Previously, CAR-T cells were armoured with immun...
Targeting immunosuppressive myeloid cells via implant-mediated slow release of small molecules to prevent glioblastoma recurrence [0.03%]
通过植入物介导缓慢释放小分子靶向免疫抑制性髓系细胞以预防胶质母细胞瘤复发
Yannik Kaiser,Christopher S Garris,Eliana Marinari et al.
Yannik Kaiser et al.
Glioblastoma is a highly aggressive brain tumour with a high risk of recurrence after surgery, even when combined with chemotherapy and radiotherapy. A major barrier to lasting treatment is the tumour's immunosuppressive environment, which ...
A HO-1 gene knockout using a NanoCRISPR scaffold suppresses metastasis in mouse models [0.03%]
基于NanoCRISPR支架的HO-1基因敲除抑制小鼠模型转移效果研究
Ning Wang,Zichao Luo,Chao Liu et al.
Ning Wang et al.
Photodynamic therapy-induced immunogenic cell death has the potential to generate autologous cancer vaccines. However, the innate or evolved genetic tolerance of tumours limits the efficacy of this approach. Here we report the development o...
Maya Ezzo,Boris Hinz
Maya Ezzo
Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis [0.03%]
靶向循环力响应性单核细胞和巨噬细胞以减少纤维化
Kellen Chen,Michelle Griffin,Dominic Henn et al.
Kellen Chen et al.
In response to injury, a variety of different cells are recruited to sites of injury to facilitate healing. Recent studies have examined the importance of the heterogeneity of tissue resident fibroblasts and mechanical signalling pathways i...