Systematic production of human kidney organoids for transplantation in porcine kidneys during ex vivo machine perfusion [0.03%]
人肾脏类器官的系统生产及其在体外机器灌注猪肾移植中的应用
Elena Garreta,Daniel Moya-Rull,Alberto Centeno et al.
Elena Garreta et al.
Organoids derived from human pluripotent stem (hPS) cells hold promise for therapeutic purposes. However, technological advances to overcome their massive production while ensuring differentiation fidelity are still lacking. Here we report ...
Steric stabilization-independent stealth cloak enables nanoreactors-mediated starvation therapy against refractory cancer [0.03%]
基于非立体稳定隐身外罩的纳米反应器介导的抗难治性肿瘤饥饿疗法
Junjie Li,Kazuko Toh,Panyue Wen et al.
Junjie Li et al.
The high interfacial energy of nanomaterials limits their certain biomedical applications that require stealthiness to minimize non-specific interaction with biological components. While steric repulsion-based entropic stabilization-such as...
NotifAI-OS: an AI framework for automated CT-based opportunistic screening in post-acute value-based care [0.03%]
基于CT的机遇性筛查人工智能框架用于急性后期以价值为基础护理中的自动预警系统（NotifAI-OS）
Rohit Reddy,Perry J Pickhardt,Arjun Manrai et al.
Rohit Reddy et al.
High-throughput evaluation of in vitro CRISPR activities enables optimized large-scale multiplex enrichment of rare variants [0.03%]
高效的体外CRISPR筛选方法实现稀有变异体的大规模多重富集
Joo Hye Yeo,Seungho Lee,Seungmin Kim et al.
Joo Hye Yeo et al.
Previous high-throughput evaluations of CRISPR activities for a large number of target and guide RNA sequences were based on measuring insertion-deletion frequencies rather than cleavage efficiencies. Here we develop two high-throughput in ...
Fangyi Guan,Ningning Bai,Jia Song et al.
Fangyi Guan et al.
Plaque accumulation in coronary arteries causes stenoses, reducing blood flow and increasing the risk of cardiovascular disorders such as heart attacks. To assess the physiological impact of blood pressure across a stenosis, commercial pres...
A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modelling [0.03%]
一种用于脑内皮细胞基因传递和脑血管畸形建模的载体病毒
Jun-Liszt Li,Zhanying Bi,Xing-Jun Chen et al.
Jun-Liszt Li et al.
Defects in brain endothelial cells (brainECs) can cause severe cerebrovascular malformations, including arteriovenous malformation (AVM) and cerebral cavernous malformation. The lack of appropriate tools for cerebrovascular disease modellin...
Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs [0.03%]
利用杂交向导RNA提高体内腺嘌呤碱基编辑疗法的特异性和效率
Madelynn N Whittaker,Lauren C Testa,Aidan Quigley et al.
Madelynn N Whittaker et al.
Phenylketonuria (PKU), pseudoxanthoma elasticum (PXE) and hereditary tyrosinemia type 1 (HT1) are autosomal recessive disorders linked to the PAH, ABCC6, and FAH and HPD genes, respectively. Here we evaluate the off-target editing profiles ...
Computational design of synthetic receptors with programmable signalling activity for enhanced cancer T cell therapy [0.03%]
用于增强癌症T细胞疗法的可编程信号活性合成受体的计算设计
Jan A Rath,Lucas S P Rudden,Nazila Nouraee et al.
Jan A Rath et al.
The tumour microenvironment (TME) plays a key role in tumour progression, and soluble and cellular TME components can limit CAR-T cell function and persistence. Targeting soluble TME factors to enhance anti-tumour responses of engineered T ...
Author Correction: Peptide design through binding interface mimicry with PepMimic [0.03%]
作者更正：通过界面模拟进行肽设计（PepMimic）
Xiangzhe Kong,Rui Jiao,Haowei Lin et al.
Xiangzhe Kong et al.
Published Erratum
Nature biomedical engineering. 2025 Oct 27. DOI:10.1038/s41551-025-01570-x 2025