HBsAg-tagged tumour vaccine system eliminates solid tumours through virus-specific memory T cells [0.03%]
HBsAg标记的肿瘤疫苗系统通过病毒特异性记忆T细胞消除实体瘤
Wenguang Wang,Ya Chu,Lili Zhao et al.
Wenguang Wang et al.
It is challenging for cancer vaccines to identify immunogenic antigens that are specifically and uniformly expressed on heterogeneous solid tumours and that can elicit production of T cells to lyse antigen-positive tumour cells and expand w...
Barriers to translating continuous monitoring technologies for preventative medicine [0.03%]
连续监测技术在预防医学中的应用障碍
Jack Chen,Patricia Jastrzebska-Perfect,Peter Chai et al.
Jack Chen et al.
While treatment remains essential, disease prevention often proves more effective in improving outcomes, enhancing well-being and reducing healthcare costs. Despite this understanding, preventative medical practices are still underutilized....
A vision-language pretrained transformer for versatile clinical respiratory disease applications [0.03%]
一种用于临床呼吸系统疾病应用的视觉语言预训练变压器模型
Liangdi Ma,Hengrui Liang,Yuwei He et al.
Liangdi Ma et al.
General artificial intelligence models have unique challenges in clinical practice when applied to diverse modalities and complex clinical tasks. Here we present MedMPT, a versatile, clinically oriented pretrained model tailored for respira...
A pre-trained large generative model for translating single-cell transcriptomes to proteomes [0.03%]
一个预训练的大生成模型，用于将单细胞转录组转化为蛋白质组
Linjing Liu,Wei Li,Fang Wang et al.
Linjing Liu et al.
Measuring protein abundance at the single-cell level can facilitate a high-resolution understanding of biological mechanisms in cellular processes and disease progression. However, current single-cell proteomic technologies face challenges ...
A microphysiological system for screening lipid nanoparticle-mRNA complexes predicts in vivo heart transfection efficacy [0.03%]
一种用于筛选脂质纳米颗粒-mRNA复合物的微生理系统可预测体内心脏转染效率
Gabriel Neiman,Mauro W Costa,Hesong Han et al.
Gabriel Neiman et al.
Gene transfection via lipid nanoparticle (LNP)-mRNA complexes have tremendous potential for treating cardiac diseases. However, the transfection efficiency is poor and there is a lack of in vitro screening systems that predict transfection ...
Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations [0.03%]
利用遗传病相关SMAD2突变的诱导多能干细胞模型揭示足细胞生成异常
Rohan Bhattacharya,Tarsha Ward,Titilola D Kalejaiye et al.
Rohan Bhattacharya et al.
Clinical observations of patients with congenital heart disease carrying SMAD2 genetic variants revealed correlations with multi-organ impairments at the developmental and functional levels. Many patients with congenital heart disease prese...
Nonexpansive biodegradable matrix promotes blood vessel organoid development for neurovascular repair and functional recovery in ischaemic stroke [0.03%]
非扩张型可降解支架促进血血管器官发生及其在缺血性脑卒中后神经血管修复和功能恢复中的作用
Dongling Xiao,Yue Sun,Guanyuan Yang et al.
Dongling Xiao et al.
Tissue engineering-based vascular reconstruction represents a promising therapeutic strategy for ischaemic stroke. However, in the confined stroke cavity, conventional implants are unable to simultaneously provide swelling-resistant support...