GaitDynamics: a generative foundation model for analyzing human walking and running [0.03%]
GaitDynamics：一种用于分析人类步行和跑步的生成基础模型
Tian Tan,Tom Van Wouwe,Keenon F Werling et al.
Tian Tan et al.
Understanding the dynamics of human gait, including both motions and forces, is vital to promote human mobility. While deep learning models may have advantages over costly laboratory-based experiments and physics-based simulations, existing...
Non-viral vectors as beacons of hope for reducing genotoxic risks of gene therapy [0.03%]
非病毒载体可降低基因治疗的致突变风险给人们带来希望
Marie-Madeleine Nzila,Ulrike Koehl,Zoltán Ivics
Marie-Madeleine Nzila
LDL-binding IL-10 reduces vascular inflammation in atherosclerotic mice [0.03%]
与LDL结合的IL-10可减轻动脉粥样硬化小鼠的血管炎症反应
Lisa R Volpatti,Salvador Norton de Matos,Gustavo Borjas et al.
Lisa R Volpatti et al.
Atherosclerosis is a chronic inflammatory disease associated with the accumulation of low-density lipoprotein (LDL) in arterial walls. Higher levels of the anti-inflammatory cytokine IL-10 in serum are correlated with reduced plaque burden....
Anchored random reverse primer sequencing for quantitative detection of novel gene fusions [0.03%]
定量检测新型基因融合的锚定随机反向引物测序法
Xuehao Xiu,Yi Wu,Jiangxue Li et al.
Xuehao Xiu et al.
Identifying novel gene fusions is critical for cancer diagnosis and drug development. While a few advanced methods have shown the capability to detect gene fusions involving unknown partners, comprehensive detection of gene fusions, especia...
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors [0.03%]
通过工程化共信号受体生成具有减少的脱靶交叉反应性的T细胞
Jose Cabezas-Caballero,Anna Huhn,Mikhail A Kutuzov et al.
Jose Cabezas-Caballero et al.
Adoptive T cell therapy using T cells engineered with novel T cell receptors (TCRs) targeting tumour-specific peptides is a promising immunotherapy. However, these TCR-T cells can cross-react with off-target peptides, leading to severe auto...
Low reactogenicity and high tumour antigen expression from mRNA-LNPs with membrane-destabilizing zwitterionic lipids [0.03%]
具有膜不稳定性双离子脂质的mRNA-LNP低反应原性和高肿瘤抗原表达
Yu Zhao,Ruoxin Li,Pingchuan Liu et al.
Yu Zhao et al.
Two key challenges in translating messenger RNA-based lipid nanoparticle (mRNA-LNP) cancer vaccines to clinical use are limited mRNA expression and unavoidable inflammatory responses. Here we develop a membrane-destabilizing zwitterionic io...
A trispecific antibody engaging T cells with tumour and myeloid cells augments antitumour immunity [0.03%]
一种三特异抗体通过T细胞与肿瘤和髓样细胞结合增强抗肿瘤免疫反应
Changrui Yang,Shanni Guo,Kaiyan Ye et al.
Changrui Yang et al.
Immunologically unresponsive tumours often resist immune checkpoint inhibitors due to the low abundance of tumour-specific T cells and an immunosuppressive microenvironment, despite pronounced infiltration of non-tumour-specific (bystander)...
Fernando Aranda,Aline Risson,Pedro Berraondo
Fernando Aranda