Neural mechanisms underlying intracortical microstimulation for sensory restoration [0.03%]
皮质内微刺激感觉恢复的神经机制研究
Christopher Hughes,Xing Chen,Warren Grill et al.
Christopher Hughes et al.
Sensation plays a pivotal role in the orchestration of our daily lives. Intracortical microstimulation (ICMS) can elicit artificial sensations in persons who have lost sensation due to neurological injury or disease. Despite ongoing clinica...
Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis [0.03%]
间歇低压可诱导衰老细胞选择性死亡并缓解年龄相关性骨质疏松症
Bowen Meng,Yan Qu,Benyi Yang et al.
Bowen Meng et al.
Senescent cell accumulation contributes to aging, and their clearance represents an effective anti-aging strategy. Current senolytic strategies focus on drug-mediated senescent cell clearance, but it is unknown whether a hypobaric condition...
Digital CRISPR-based diagnostics for quantification of Candida auris and resistance mutations [0.03%]
数字CRISPR诊断技术用于量化耳霉菌及其耐药突变体
Justin C Rolando,Anton Thieme,Nicole E Weckman et al.
Justin C Rolando et al.
Candida auris, an increasingly prevalent fungal pathogen, requires both rapid identification and antifungal susceptibility testing to enable proper treatment. This study introduces digital SHERLOCK (dSHERLOCK), a platform that combines CRIS...
A chemiluminescence assay targeting granzyme A activity for monitoring inflammatory bowel disease [0.03%]
一种针对粒酶A活性的化学发光检测法在监测炎症性肠病中的应用
Jamie I Scott,Zhiming Cheng,Emily J Thompson et al.
Jamie I Scott et al.
The diagnosis and monitoring of inflammatory bowel disease (IBD) relies on histologic and endoscopic analysis, as well as measurements of generic markers of inflammation. However, there are no specific tests that report on T cell-mediated i...
Small intracellular vesicles outperform small extracellular vesicles in uptake, drug delivery and retinal neuroprotection [0.03%]
小细胞内囊泡比小细胞外囊泡在摄取、药物输送和视网膜神经保护方面表现更佳
Hui Zhang,Xinyue Yu,Fuhua Yang et al.
Hui Zhang et al.
Small extracellular vesicles have been widely studied for their therapeutic properties and ability to deliver bioactive molecules. In addition to secretory vesicles, cells contain small intracellular vesicles involved in physiological and m...
Real-time multimodal phenotyping reveals distinct tumour cell dynamics and immune escape mechanisms in T cell therapies [0.03%]
实时多模态表型分析揭示了T细胞治疗中的肿瘤细胞动态和免疫逃逸机制
Shengjie Chen,Kunru Yu,Shengsen Zhang et al.
Shengjie Chen et al.
Adoptive T cell transfer therapy remains limited by the inability to monitor live tumour cell dynamics during treatment. Here we introduce a real-time, label-free phenotyping system that integrates electrical impedance spectroscopy, Raman s...
Wireless and bioresorbable triboelectric nerve block system for postoperative pain control [0.03%]
用于术后止痛的无线且可生物降解的摩擦电神经阻断系统
Young-Jun Kim,So-Hee Kim,Byung-Joon Park et al.
Young-Jun Kim et al.
Amidst the chronic issue of opioid misuse, finding an alternative to pharmaceutical pain control following surgical interventions stands as a major hurdle. Conventional non-pharmacological pain control technologies often rely on rigid stimu...
A deep learning and large language hybrid workflow for omics interpretation [0.03%]
一种用于组学解释的深度学习和大型语言混合工作流
Dachao Tang,Chi Zhang,Weizhi Zhang et al.
Dachao Tang et al.
Profiling molecular panorama from massive omics data identifies regulatory networks in cells but requires mechanistic interpretation and experimental follow up. Here we combine deep learning and large language model reasoning to develop a h...
Engineered outer membrane vesicles enhance solid tumour CAR-T cell therapy [0.03%]
工程化外膜囊泡增强实体肿瘤CAR-T细胞治疗
Xianjun Li,Xuehan Li,Jiaqi Shi et al.
Xianjun Li et al.
Major challenges facing chimeric antigen receptor (CAR)-T cell therapy for solid tumours include the immunosuppressive tumour microenvironment and the heterogeneity of antigen expression. Bacterial outer membrane vesicles (OMVs) naturally a...
A multimodal vision-language model for generalizable annotation-free pathology localization [0.03%]
一种通用且无需标注的数据驱动的病理定位视觉语言模型
Hao Yang,Hong-Yu Zhou,Jiarun Liu et al.
Hao Yang et al.
Existing deep learning models for defining pathology from clinical imaging data rely on expert annotations and lack generalization capabilities in open clinical environments. Here we present a generalizable vision-language model for Annotat...