Jun Wen,Sihang Zeng,Clara-Lea Bonzel et al.
Jun Wen et al.
Missense variants (MVs) influence clinical phenotypes, but our understanding of their phenotypic consequences remains constrained. Existing computational approaches to interpret MVs predominantly assess their pathogenicity, without consider...
Guo-Qing Fang,Yuan Deng,Xin-Yuan Lyu et al.
Guo-Qing Fang et al.
Prime editing (PE) enables precise genetic modifications using canonical prime editing guide RNA (pegRNA), with the reverse transcription template and primer binding site (RTT-PBS) attached to the 3' ends of CRISPR-Cas guide RNAs. Although ...
Haojun Yu,Youcheng Li,Nan Zhang et al.
Haojun Yu et al.
Foundation models have emerged as powerful tools for addressing various tasks in clinical settings. However, their potential development for breast ultrasound analysis remains untapped. Here we present BUSGen, the first foundation generativ...
Hyeong-Cheol Oh,Yoojin Chang,Jihye Park et al.
Hyeong-Cheol Oh et al.
The androgen receptor (AR) plays a central role in the progression and therapy resistance of prostate cancer, the most common cancer in men. While AR signalling inhibitors such as enzalutamide are key treatments, their efficacy is often com...
Programmable kinetic barcoding for multiplexed RNA detection with Cas13a [0.03%]
利用Cas13a实现多重RNA检测的可编程动力学条形码技术
Sungmin Son,Amy Lyden,Carlos F Ng et al.
Sungmin Son et al.
Rapid identification of viral infections and specific variants in patient samples requires a simple and multiplexed RNA detection method that does not rely on DNA sequencing. Although recent direct detection assays based on CRISPR-Cas13a of...
Empowering AI data scientists using a multi-agent LLM framework with self-evolving capabilities for autonomous, tool-aware biomedical data analyses [0.03%]
一种多代理LLM框架，用于赋能AI数据科学家进行自主、工具意识的生物医学数据分析
Dechao Bu,Jingbo Sun,Kun Li et al.
Dechao Bu et al.
Artificial intelligence agents are emerging as powerful applications of large language models (LLMs), automating complex tasks and enabling scientific data exploration. However, their use in biomedical data analysis remains limited by the d...
Human microphysiological systems of aging recreate the in vivo process expediting evaluation of anti-geronic strategies [0.03%]
人类衰老微生理系统重现体内衰老进程，加速抗衰老策略评估
Lin Qi,Yuchen He,Alexandra Sviercovich et al.
Lin Qi et al.
The search for biological mechanisms of human aging is stalled by a lack of suitable models, and it remains unknown whether and to what degree rejuvenation reported in rodents translates to people. Here we report a human induced pluripotent...
Rohan Shad,Cyril Zakka,Dhamanpreet Kaur et al.
Rohan Shad et al.
Cardiac MRI allows for a comprehensive assessment of myocardial structure, function and tissue characteristics. Here we describe a foundational vision system for cardiac MRI, capable of representing the breadth of human cardiovascular disea...