STRAIGHT-IN Dual: a platform for dual single-copy integrations of DNA payloads and gene circuits into human induced pluripotent stem cells [0.03%]
一种双单拷贝整合DNA负载和基因线路进入人类诱导多能干细胞的平台(straight-in_dual)
Albert Blanch-Asensio,Deon S Ploessl,Benjamin B Johnson et al.
Albert Blanch-Asensio et al.
Targeting DNA payloads into human induced pluripotent stem cells (hiPSCs) typically requires multiple inefficient steps, slowing the testing of gene circuits and cell-fate programmes. Here we show that STRAIGHT-IN Dual enables simultaneous,...
Non-viral targeted integration of large DNA in primary human T cells independent of double-stranded DNA breaks [0.03%]
无需双链DNA断裂即可在原代人T细胞中进行大片段基因组DNA的靶向整合
Sen Fang,Na Tang,Yiyun Li et al.
Sen Fang et al.
Non-viral targeted integration of large DNA cargoes into human primary T cells typically requires the induction of genomic double-strand breaks (DSBs), a process associated with cytotoxicity and potential tumorigenic chromosomal abnormaliti...
Publisher Correction: High-resolution functional mapping of androgen receptor variants [0.03%]
出版更正：雄激素受体变异的高分辨率功能映射
Hyeong-Cheol Oh,Yoojin Chang,Jihye Park et al.
Hyeong-Cheol Oh et al.
Published Erratum
Nature biomedical engineering. 2026 Apr 27. DOI:10.1038/s41551-026-01690-y 2026
A geometry aware framework enhances noninvasive mapping of whole human brain dynamics [0.03%]
一种几何感知框架提升了整个人脑动态非侵入性测绘技术
Song Wang,Kexin Lou,Chen Wei et al.
Song Wang et al.
Non-invasive electrophysiology lacks methods that accurately reconstruct whole-brain spatiotemporal dynamics while incorporating individual cortical geometry, leaving current electroencephalography and magnetoencephalography source imaging ...
David C Garrett,Jinhua Xu,Donghyeon Oh et al.
David C Garrett et al.
Ultrasonography is a vital component of modern clinical care, with handheld probes routinely used for diagnostic imaging and procedural guidance. However, handheld ultrasound imaging is limited by factors such as the partial cross-sectional...
DeepDrugDiscovery identifies blood-brain barrier permeable autophagy enhancers for Alzheimer's disease [0.03%]
深度药物发现识别增强自噬的小分子以治疗阿尔茨海默病
Yu Dong,Xianglu Xiao,Xu-Xu Zhuang et al.
Yu Dong et al.
Dysfunctional autophagy, a key cellular cleaning process, is a key driver of brain ageing and neurodegenerative diseases such as Alzheimer's disease (AD). However, developing effective treatments by enhancing autophagy has been challenging,...
A three-dimensional multi-modal foundation model for optical coherence tomography [0.03%]
一种用于光学相干断层扫描的三维多模态基础模型
Zixuan Liu,Hanwen Xu,Addie Woicik et al.
Zixuan Liu et al.
Vision loss caused by retinal diseases remains a leading global cause of disability. Optical coherence tomography (OCT) is an imaging technique that is used for diagnosing retinal diseases. Computational models can use OCT images for variou...
Yun Chang,Kunming Shao,Huiyang Li et al.
Yun Chang et al.
Despite their notable abundance in circulation and biological significance in the tumour microenvironment, direct genetic programming of neutrophils has been challenging. Here we develop a neutrophil-specific modified RNA translation platfo...
Pre-intervention with intravenous immunoglobulin reverses the immunogenic clearance of PEGylated nanomedicines [0.03%]
静脉注射免疫球蛋白预处理可逆转聚乙二醇纳米药物的免疫清除现象
Keren Lai,Peiyi He,Yuejian He et al.
Keren Lai et al.
Nanomedicines are susceptible to immunogenic clearance before reaching their disease targets, thereby limiting their pharmacodynamic efficacy. To overcome this challenge, PEGylation has been developed and widely used. However, in therapies ...
Cheng Wang,Yu Jiang,Zhihao Peng et al.
Cheng Wang et al.
Functional magnetic resonance imaging (fMRI) is crucial for studying brain function and diagnosing neurological disorders. However, existing analysis methods suffer from reproducibility and transferability challenges due to complex preproce...