Pharmacokinetic tuning of protein-antigen fusions enhances the immunogenicity of T-cell vaccines [0.03%]
蛋白质抗原融合的药代动力学调整可增强T细胞疫苗的免疫原性
Naveen K Mehta,Roma V Pradhan,Ava P Soleimany et al.
Naveen K Mehta et al.
The formulations of peptide-based antitumour vaccines being tested in clinical studies are generally associated with weak potency. Here, we show that pharmacokinetically tuning the responses of peptide vaccines by fusing the peptide epitope...
Sahab Babaee,Simo Pajovic,Ahmad Rafsanjani et al.
Sahab Babaee et al.
Falls and subsequent complications are major contributors to morbidity and mortality, especially in older adults. Here, by taking inspiration from claws and scales found in nature, we show that buckling kirigami structures applied to footwe...
A fidget spinner for the point-of-care diagnosis of urinary tract infection [0.03%]
一种用于床旁检测尿路感染的手动摇杆盘游戏玩具改良性装置
Issac Michael,Dongyoung Kim,Oleksandra Gulenko et al.
Issac Michael et al.
The point-of-care detection of pathogens in biological samples in resource-limited settings should be inexpensive, rapid, portable, simple and accurate. Here, we describe a custom-made fidget spinner that rapidly concentrates pathogens in 1...
Jürgen Scheller,Philipp A Lang
Jürgen Scheller
Sustained suppression [0.03%]
持续压制
Further COVID-19 outbreaks are unavoidable. To detect and suppress them, governments ought to implement a range of public health measures aided by technology.
Sustained suppression [0.03%]
持续抑制疗法
Further COVID-19 outbreaks are unavoidable. To detect and suppress them, governments ought to implement a range of public health measures aided by technology.
Kim Henriksen,Morten A Karsdal
Kim Henriksen
A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs [0.03%]
超分子稳定胰岛素与普兰林肽共配方可增强糖尿病猪餐后 glucagon 的抑制作用
Caitlin L Maikawa,Anton A A Smith,Lei Zou et al.
Caitlin L Maikawa et al.
Treatment of patients with diabetes with insulin and pramlintide (an amylin analogue) is more effective than treatment with insulin only. However, because mixtures of insulin and pramlintide are unstable and have to be injected separately, ...
De novo development of proteolytically resistant therapeutic peptides for oral administration [0.03%]
用于口服给药的耐蛋白水解治疗性肽的从头开发
Xu-Dong Kong,Jun Moriya,Vanessa Carle et al.
Xu-Dong Kong et al.
The oral administration of peptide drugs is hampered by their metabolic instability and limited intestinal uptake. Here, we describe a method for the generation of small target-specific peptides (less than 1,600 Da in size) that resist gast...
David J Brayden
David J Brayden