High-efficiency TadA cytosine base editors for precise modelling of human disease variants [0.03%]
高效的TadA胞嘧啶基础编辑器可精准建模人类疾病变异体
Wei Qin,Sheng-Jia Lin,Yu Zhang et al.
Wei Qin et al.
Many missense mutations identified in genetic testing are variants of uncertain significance (VUS), not yet classified as either benign or pathogenic. Systematic determination of their functional relevance is a pressing clinical need. CRISP...
Xeno-learning: knowledge transfer across species in deep learning-based spectral image analysis [0.03%]
基于深度学习的光谱图像分析中的跨物种知识迁移
Jan Sellner,Alexander Studier-Fischer,Ahmad Bin Qasim et al.
Jan Sellner et al.
Optical imaging techniques, such as hyperspectral imaging combined with machine learning-based analysis, have the potential to revolutionize clinical surgical imaging. However, these modalities face a shortage of large-scale, representative...
A filamentary soft robotic probe for multimodal in utero monitoring of fetal health [0.03%]
一种用于监测胎儿健康的宫内多模态柔软机器人探测器
Hedan Bai,Jianlin Zhou,Mingzheng Wu et al.
Hedan Bai et al.
Fetal surgery offers valuable opportunities to address severe congenital disabilities, yet accurate evaluation of fetal physiological changes during in utero procedures to mitigate the risk of operative complications remains an unmet need. ...
Human gastric multi-regional assembloids for functional parietal maturation and patient-specific modelling of antral foveolar hyperplasia [0.03%]
人胃多区域组装体促进壁细胞成熟及幽门腺小凹增生的患者特异性建模研究
Brendan C Jones,Giada Benedetti,Giuseppe Calà et al.
Brendan C Jones et al.
Patient-derived human organoids have the capacity to self-organize into more complex structures. However, to what extent gastric organoids can recapitulate differentiated cell types and mucosal functions remains unexplored. Here we report o...
The AI sycophant [0.03%]
人工智能谄媚者
Rita Strack
Rita Strack
A droplet solution for wrapping thin bioelectronics onto complex 3D surfaces [0.03%]
一种液滴解决方案 可以将薄生物电子设备包裹到复杂的三维曲面中
Valeria Caprettini
Valeria Caprettini
Sadra Bakhshandeh
Sadra Bakhshandeh
Making large language models reliable data science programming copilots for biomedical research [0.03%]
使大型语言模型成为生物医学研究中可靠的数据科学编程副驾
Zifeng Wang,Benjamin Danek,Ziwei Yang et al.
Zifeng Wang et al.
Large language models (LLMs) can generate impressive data visualizations from simple requests, yet their accuracy remains underexplored. Here we present a benchmark of 293 coding tasks derived from 39 studies across 7 biomedical research ar...