Temporal interference stimulation for deep brain neuromodulation in humans [0.03%]
人类深部脑神经调控的时序干扰刺激法
Pierre Vassiliadis,Elena Beanato,Maximilian J Wessel et al.
Pierre Vassiliadis et al.
Deep brain stimulation needs high focality in deep parts of the brain; hence, it has largely relied on invasive surgical approaches in clinical populations. Transcranial temporal interference stimulation (tTIS) has emerged as a method for f...
Bridging the interpretability gap for medical artificial intelligence models using class-association manifold learning [0.03%]
基于类关联流形学习的医学人工智能模型可解释性研究桥梁方法
Ruitao Xie,Xiaoxi He,Limai Jiang et al.
Ruitao Xie et al.
Explainability has increasingly become a core requirement for intelligent medical devices. Current medical artificial intelligence (AI) technologies suffer from the 'interpretability gap' despite tremendous efforts for enhancing explainabil...
Wireless and in situ regenerable multimodal wearable bioelectronic sweat sensor for continuous biomarker monitoring in everyday settings [0.03%]
用于日常环境中连续生物标志物监测的无线和原位再生型多模态可穿戴生物电子汗传感器
Jerome Rajendran,Xiaochang Pei,Shingirirai Chakoma et al.
Jerome Rajendran et al.
Wearable sweat-sensing technologies are limited by their inability to detect multiple molecular biomarkers, lack of multimodal capabilities, insufficient environmental robustness and the absence of in situ regenerability needed for long-ter...
Liposomal nanoprobes actuated by engineered water channels for sensitive detection of molecular targets by MRI [0.03%]
由工程化水通道激活的脂质体纳米探针用于分子靶标的MRI检测
Sayani Das,Jacob Cyert Simon,Miranda Dawson et al.
Sayani Das et al.
Monitoring biochemical processes requires tools to detect specific molecular species in vivo. Although responsive probes detectable by MRI enable this, conventional MRI contrast agents often lack sufficient sensitivity. Here we circumvent t...
Fundamental limitations of kilohertz-frequency carriers in afferent fibre recruitment with transcutaneous spinal cord stimulation [0.03%]
高频载体在经皮脊髓刺激中募集传入纤维的基本限制
Rodolfo Keesey,Ursula Hofstoetter,Zhaoshun Hu et al.
Rodolfo Keesey et al.
Kilohertz-frequency (KHF) waveforms are gaining traction in transcutaneous spinal cord stimulation (tSCS) for motor recovery after paralysis. However, the mechanisms by which these fast-alternating currents depolarize proprioceptive afferen...
Mechanical force-induced tissue remodelling in a clinically relevant microphysiological model of asthmatic human lungs [0.03%]
临床相关哮喘人体肺微生理模型中的机械力诱导组织重塑
Jungwook Paek,Lakshminarayan Reddy Teegala,Farid Alisafaei et al.
Jungwook Paek et al.
Structural remodelling of living tissues due to mechanical forces is a common occurrence that plays an essential role in development, health and disease, but preclinical investigation of this dynamic process in human-relevant conditions rem...
Engineering challenges and translational opportunities in emerging gene delivery platforms [0.03%]
新兴基因传递平台面临的工程挑战及转化机遇
Yifan Ma,Shiyan Dong,Annette Wu et al.
Yifan Ma et al.
The clinical success of gene therapy depends critically on the development of delivery platforms capable of achieving precise, efficient and tissue-specific delivery of genetic payloads in vivo. A diverse array of carriers, including viral,...
Polymer-mRNA complexes for monocyte-trafficked, lymph node-targeted cancer vaccination [0.03%]
用于单核细胞运输和淋巴结靶向的癌症疫苗的聚合物-mrna复合物
Qiongzhe Ren,Xiaofei Zhao,Lili Zhou et al.
Qiongzhe Ren et al.
Lymph nodes are the primary sites where adaptive immunity is initiated, yet most messenger RNA cancer vaccines reach them inefficiently and instead accumulate in organs such as the liver, limiting therapeutic potency and increasing systemic...
Towards generalizable AI in medicine via Generalist-Specialist Collaboration [0.03%]
通过一般专家合作实现医学中通用人工智能
Sunan He,Yuxiang Nie,Hongmei Wang et al.
Sunan He et al.
Generalist foundation models (GFMs) are renowned for their exceptional capability and flexibility in diverse tasks. In the field of medicine, while GFMs exhibit superior generalizability, specialist models excel in precision because of thei...