Predicting metabolic dysfunction-associated steatotic liver disease risk using patient-derived induced pluripotent stem cells [0.03%]
使用患者诱导多能干细胞预测代谢功能异常相关肝脂质蓄积症风险
Yuanyuan Qin,Parth Chhetri,Elizabeth Theusch et al.
Yuanyuan Qin et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is reversible at early stages, making early identification critical. We previously demonstrated that patient-derived induced pluripotent stem cells (iPSCs) carrying MASLD-asso...
Modeling rare genetic disease with gene-edited induced pluripotent stem cells: relevance of the starting stock line [0.03%]
采用基因编辑诱导多能干细胞模拟罕见遗传病：起始株系的相关性研究
Ashok R Dinasarapu,Diane J Sutcliffe,Erkin Ozel et al.
Ashok R Dinasarapu et al.
Induced pluripotent stem cells (iPSCs) are commonly used to model human genetic diseases. Two main strategies are used. The first involves making iPSC lines from individual cases with a disease, and the second involves making disease-releva...
Potency of human hematopoietic cells from a novel CD34+ isolation technique [0.03%]
一种新型CD34阳性分离技术获得的人造血细胞的潜能
James Ropa,Jimin Park,Jessica Newton et al.
James Ropa et al.
Hematopoietic stem and progenitor cells are responsible for maintenance of the immune system and can be a source of cells for therapies. A critical step in studying or utilizing hematopoietic cells is subpopulation isolation. FerroBio is an...
Mesenchymal stem cell-derived exosome delivery of let-7a-5p enhances macrophage efferocytosis via Arid3a/Mertk axis in acute-on-chronic liver failure [0.03%]
间充质干细胞衍生的外泌体递送let-7a-5p通过Arid3a/Mertk轴促进急性-on-慢性肝功能衰竭中巨噬细胞的胞葬作用
Junyi Wang,Zhihui Li,Zhouhan Wang et al.
Junyi Wang et al.
Background: Acute-on-chronic liver failure (ACLF) is a severe clinical syndrome with a high mortality rate and limited therapeutic options. Macrophage efferocytosis plays an essential role in maintaining tissue homeostasi...
Harnessing 3D cultured MSC exosomes through tangential flow filtration for enhanced diabetic wound healing [0.03%]
通过切向流过滤利用三维培养的间充质干细胞外泌体增强糖尿病创面修复
Yanmei Chen,Yang Xu,Yali Zheng et al.
Yanmei Chen et al.
Introduction: Mesenchymal stem cell-derived exosomes have garnered considerable attention in regenerative medicine due to their non-immunogenicity, low infusion toxicity, easy accessibility, straightforward preservation, ...
Comparative analysis of scaffold-free tissue-engineered cartilage derived from different seed cells: in vitro and in vivo studies [0.03%]
来源于不同种源细胞的无支架组织工程软骨体外及体内比较研究
Mengxin Xue,Kaiwen Zheng,Jiewei Chen et al.
Mengxin Xue et al.
Objective: The development of cartilage tissue engineering offers a promising strategy for effective cartilage regeneration. This study aims to synthesize scaffold-free tissue-engineered cartilage (TEC) using articular ch...
Comparative Study
Stem cells translational medicine. 2025 Nov 24;14(12):szaf057. DOI:10.1093/stcltm/szaf057 2025
Intrathecal versus intravenous umbilical cord mesenchymal stem cells for ischemic stroke sequelae [0.03%]
脐带间充质干细胞脑池内注射与静脉注射治疗卒中后遗症的比较研究
Liem Thanh Nguyen,Thuy Thi Ngoc Nguyen,Kien Trung Nguyen et al.
Liem Thanh Nguyen et al.
Background: Stroke is a leading cause of death worldwide. Traditional treatments have limitations, stem cell therapy has potential for regeneration after ischemic stroke. This study evaluated the safety and efficacy of al...
Tracking leukemic residuals: dissecting the inverse relationship between CD26+ stem cells and extracellular BCR::ABL1 transcript in Chronic Myeloid Leukemia (CML) [0.03%]
追踪白血病残留：探讨慢性粒细胞白血病(CML)中CD26+干细胞与胞外BCR::ABL1转录物之间的反比关系
Silvia Mutti,Alessia Cavalleri,Anna Sicuranza et al.
Silvia Mutti et al.
Chronic myeloid leukemia (CML) persists due to leukemic stem cells, notably the CD26+ subset. We investigated correlations between circulating CD26+ leukemic stem cells (LSCs) and BCR::ABL1 transcripts in an extracellular vesicle-enriched s...
Teratoma-free cartilage regeneration using p21-/- iPSCs engineered with iCasp9 [0.03%]
利用iCasp9基因工程改造的p21缺失的诱导多能干细胞进行无畸胎瘤软骨再生
Leila Larijani,Derrick Rancourt,Roman J Krawetz
Leila Larijani
Objective: Articular cartilage has limited regenerative capacity due to its lack of innervation, vascularization, and lymphatic vessels. As cartilage is devoid of nerves, injuries often go unnoticed until degeneration lea...
Combining genome and tissue engineering for next-generation human biomimetics [0.03%]
结合基因组和组织工程技术进行下一代人体仿生学研究
Eric K N Gähwiler,Valery L Visser,Melanie Generali et al.
Eric K N Gähwiler et al.
Tissue engineering for cardiovascular implants has largely utilized primary human cells to generate human tissue-engineered matrices (hTEMs). However, due to donor-to-donor variability and limited passage numbers, a more robust alternative ...