Histone acetylation promotes FKBP5 to increase reparative dentin formation in pulp repair [0.03%]
组蛋白乙酰化促进FKBP5增加牙髓修复中修复性牙本质的形成
Shaoying Duan,Qianqian Su,Hui Yang et al.
Shaoying Duan et al.
Importance: A well-formed dentin bridge isolates irritants and prevents bacterial penetration into the remaining pulp tissue, which is essential for pulp regeneration. The existing literature on promoting reparative denti...
Lysine methyltransferase methyltransferase-like 13 regulates bone marrow mesenchymal stem cells osteo-adipogenic differentiation and senescence in osteoporosis via the Foxa1/HES-1 axis [0.03%]
组蛋白赖氨酸甲基转移酶_like_13通过Foxa1/HES_1轴调控骨髓间充质干细胞成软骨/脂分化及衰老在骨质疏松中的作用机制研究
Ying Liu,Ao Wang,Ziwen Liu et al.
Ying Liu et al.
Purpose: Recent research indicates that the senescence of bone marrow mesenchymal stem cells (BMSCs) disrupts the osteo-adipogenic balance, a primary factor contributing to the development of osteoporosis. Our previous fi...
From elective protocols to emergency reality: rethinking adipose tissue harvesting for stromal vascular fraction applications [0.03%]
从选择性协议到紧急现实：重新考虑脂肪组织收获以应用于血管基质组分
Caroline Nonnarath,Nicolas Serratrice
Caroline Nonnarath
Background: Adipose tissue is a readily accessible source of stromal vascular fraction (SVF) and adipose-derived stem/stromal cells, widely used in regenerative medicine. Current harvesting and processing standards are de...
A Phase 1 clinical trial to evaluate the safety and tolerability of CLZ-2002 for the treatment of patients with Charcot-Marie-Tooth disease type 1 [0.03%]
评估CLZ-2002治疗I型夏科马里托 Tooth 病患者的安全性与耐受性的 I 期临床试验
Hyesun Kim,Byung-Ok Choi,Hyunju Lee et al.
Hyesun Kim et al.
Background: Charcot-Marie-Tooth disease type 1 (CMT1) is a rare, genetically diverse condition and represents the most prevalent form of inherited peripheral neuropathy, characterized by Schwann cell dysfunction resulting...
Five-year follow-up of phase II trial of autologous cord blood mononuclear cells for bronchopulmonary dysplasia prevention in very preterm infants [0.03%]
极早产婴儿自体脐带血单个核细胞预防支气管肺发育不良II期临床研究的5年随访
Zhuxiao Ren,Jiangxue Han,Qi Zhang et al.
Zhuxiao Ren et al.
Background: We previously performed a phase II clinical trial involving the intravenous infusion of autologous cord blood mononuclear cells (ACBMNCs) to prevent bronchopulmonary dysplasia in premature infants. We reported...
Stem cell-based therapies for neuroretinal degeneration: current landscape and future perspectives [0.03%]
基于干细胞的神经视网膜退行性病变治疗：现状与未来展望
Sarah Saietz,Filippo Locri,Helena Isla-Magrané et al.
Sarah Saietz et al.
Retinal degenerations, comprising a heterogeneous group of disorders culminating in neuroretinal dysfunction, such as inherited retinal dystrophies (IRDs) and age-related retinal degeneration, are among the leading causes of irreversible vi...
A human iPSC-derived 3D spinal cord organoid model to study radiation-induced neural injury [0.03%]
人多能干细胞来源的三维脊髓类器官模型研究放射性神经损伤
Yifei Jiang,Xubo Li,Jingguang Zeng et al.
Yifei Jiang et al.
Background: Radiation therapy remains a cornerstone in the treatment of primary and metastatic tumors; however, its efficacy is limited by the spinal cord's high sensitivity to radiation-induced injury. To better understa...
Kazuto Kimura,Masaya Tsukamoto,Kohei Shishida et al.
Kazuto Kimura et al.
Background: Red blood cell (RBC) transfusions are essential for treating various medical conditions, but global demand is difficult to meet due to a dwindling donor pool and compatibility issues. Pluripotent stem cells (P...
Inhibition of inflammation and senescence with azole compound C7 enables expansion of hematopoietic stem and progenitor cells [0.03%]
azole化合物C7通过抑制炎症和衰老促进造血干细胞和祖细胞的扩增
Ze Hui Kok,Lin Ming Lee,Kelvin Y H Liu et al.
Ze Hui Kok et al.
Human hematopoietic stem and progenitor cells (HSPCs) derived from umbilical cord blood (UCB) are often insufficient in quantity for transplantation, necessitating efforts for ex vivo expansion. We previously developed a novel azole-based s...
The role of endothelial colony forming cells in the treatment of limb ischaemia: challenges in clinical translation [0.03%]
内皮集落形成细胞在治疗四肢缺血中的作用：临床转化的挑战
Christine Ayu Lagonda,Caomhán J Lyons,Yaqiong Liu et al.
Christine Ayu Lagonda et al.
Endothelial colony forming cells (ECFCs) are emerging as a promising therapeutic option for treating various vascular and degenerative disorders. These cells, also known as endothelial progenitor cells, which play a crucial role in angiogen...