Autologous muscle precursor cell injection into the bladder neck improves the symptoms of stress urinary incontinence in adult females [0.03%]
自体肌肉干细胞注射至膀胱颈可改善成年女性压力性尿失禁症状
Rahul Dutta,James J Yoo,Anthony Atala et al.
Rahul Dutta et al.
Background: The transplantation of autologous muscle precursor cells (MPCs) is effective in the regeneration of muscle in multiple pathologies. This phase I clinical trial sought to use MPCs to treat stress urinary incont...
Artificial intelligence and systems biology analysis in stem cell research and therapeutics development [0.03%]
干细胞研究和治疗中的人工智能及系统生物学分析
Thayna Silva-Sousa,Júlia Nakanishi Usuda,Nada Al-Arawe et al.
Thayna Silva-Sousa et al.
Background: Stem cell research has rapidly advanced during the past decades, but the translation into approved clinical products is still lagging behind. Multiple barriers to effective clinical translation exist. We hypot...
Microencapsulated 3D culture of human umbilical cord-derived mesenchymal stem cells enhances their therapeutic effect on intrauterine adhesion [0.03%]
微囊化三维培养的人源脐带间充质干细胞可增强其治疗宫腔粘连的疗效
Hongjiang Liu,Xiaohua Jiang,Jin Qian et al.
Hongjiang Liu et al.
Therapeutic application of mesenchymal stem cells is emerging as a potential strategy for the management of intrauterine adhesion (IUA). However, conventional 2D cultures often face issues such as insufficient cell quantities and suboptimal...
YingYing Wei,Bin Zhang,Qingli Bie et al.
YingYing Wei et al.
Background: Aging is an inevitable and complex biological process characterized by progressive cellular and functional deterioration, leading to increased disease susceptibility and mortality. Stem cells, endowed with uni...
Rapid manufacturing of angiogenic cellular collagen patches for ischemic cardiomyopathy [0.03%]
用于缺血性心肌病的促血管生成细胞胶原补片的快速制造技术
Eric Pfrender,Sungwoo Kim,John A Farag et al.
Eric Pfrender et al.
Background: One in ten Americans carry a lifetime risk of ischemic heart failure, the most severe form of ischemic heart disease. Carrying a nearly 50% five‑year mortality rate, no interventional therapy exists to treat ...
Mesenchymal progenitor-derived proteoglycan 4 regulates the transdifferentiation of chondrocytes into osteoblasts during fracture healing [0.03%]
骨折愈合过程中软骨膜源性蛋白聚糖4调控软骨细胞成骨转分化功能及其机制研究
Nicoletta Ninkovic,Jessica May Corpuz,Alana Stahl et al.
Nicoletta Ninkovic et al.
Introduction: Proteoglycan 4 (PRG4), also known as lubricin, is essential for maintaining tissue homeostasis and acts as a lubricant that protects joint surfaces from wear and tear. Our previous studies have demonstrated ...
Preclinical efficacy of adipose-derived cell therapies for the treatment of myositis [0.03%]
脂肪衍生细胞疗法治疗肌炎的临床前疗效
Baptiste Pileyre,Silvia Gandolfi,Catalina Abad et al.
Baptiste Pileyre et al.
Importance: Idiopathic inflammatory myopathies, commonly referred as myositis, are autoimmune diseases that cause muscle damage, progressive weakness, and disability. Current treatments, including corticosteroids and immu...
Anti-tumor effect of intratumoral administration of induced pluripotent stem cell-derived NKT cells on glioblastoma through CD155/DNAM-1 interaction [0.03%]
诱导多能干细胞来源的NKT细胞通过CD155/DNAM-1相互作用对胶质母细胞瘤的抗肿瘤效应
Ko Ozaki,Takahiro Aoki,Masayoshi Kobayashi et al.
Ko Ozaki et al.
Background: Glioblastoma is the most malignant brain tumor with the poorest prognosis, but there have been no significant therapeutic advances in the past 20 years. Intratumoral administration of invariant natural killer ...
Hematopoietic stem cell therapy with gene modification to treat sickle cell disease [0.03%]
基因改良造血干细胞治疗镰状细胞病
Julia Ball,Avery Bradley,Anh Le et al.
Julia Ball et al.
Hematopoietic stem cells (HSCs) reconstitute blood cells throughout life. DNA-level correction of HSCs allows for a one-time cure of genetic diseases, including sickle cell disease (SCD). Sickle cell disease is one of the most common single...
Distal lung organoids derived from adult stem cells as novel tools in deciphering mechanisms of lung regeneration, infection, and cancer [0.03%]
成人干细胞衍生的远端肺类器官在解析肺再生、感染和癌症机制方面的新工具
Mark Bell,Anna D Krasnodembskaya
Mark Bell
While lung research has made great strides in understanding lung physiology, lung pathology still presents a major burden to patients and healthcare systems globally. To develop new effective therapeutics to improve lung regeneration, preve...