Loss of PDL1 in mesenchymal stromal cells from young-onset MDS-RAEB-1 promotes inflamm-aging through epigenetic dysregulation of H3K9me3 [0.03%]
年轻发病MDS-RAB-1来源的间充质基质细胞中PDL1丢失通过H3K9me3表观遗传失调促进衰老相关炎症反应
Pengju Lv,Ranran Jin,Lei Sun et al.
Pengju Lv et al.
Myelodysplastic syndromes (MDS), an age-related hematological malignancy, involve dysfunctional bone marrow mesenchymal stromal cells (BM-MSCs). Our study reveals that BM-MSCs from young refractory anemia with excess of blasts-1 (RAEB-1)/MD...
Safety of intravascular administration of umbilical-cord-derived mesenchymal stromal cells: an updated systematic review and meta-analysis [0.03%]
胎盘来源间充质基质细胞静脉输注安全性：系统性回顾和meta分析更新
Christine Hum,Jessica Poliwoda,Manoj Lalu et al.
Christine Hum et al.
Background: Mesenchymal stromal cells (MSCs) have the capacity to self-renew and exert immunomodulatory and paracrine effects. Our previously published systematic review of 55 randomized controlled trials (RCTs) of all MS...
Five-year follow-up outcomes after phase 1 trial of mesenchymal stromal cells for periventricular hemorrhagic infarction in preterm infants [0.03%]
早产儿脑室周围白质损伤后进行间充质基质细胞一期临床试验5年随访结果
Misun Yang,So Yoon Ahn,Se In Sung et al.
Misun Yang et al.
Periventricular hemorrhagic infarction (PVHI), commonly referred to as grade 4 intraventricular hemorrhage, is a serious neurological disorder in premature infants with no established disease-modifying therapy. This study evaluated the long...
Imbalance in WNT: retinoic acid signaling dysregulates HOX gene expression: implications for cancer stem cell heterogeneity and CRC patient survival [0.03%]
WNT：视黄酸信号紊乱调节HOX基因表达：对癌症干细胞异质性和结直肠癌患者生存率的启示
Brian Osmond,Chi Zhang,Pascal K Kataboh et al.
Brian Osmond et al.
How HOX transcription factors play a role in the stem cell (SC) origin of cancer is unclear. Our goal is to determine how dysregulation of HOX gene expression promotes colorectal cancer (CRC) development through aberrant SC regulatory mecha...
Factors affecting outcomes of intra-articular injection of autologous, culture-expanded, adipose-derived mesenchymal stem cells in knee osteoarthritis [0.03%]
自体扩增脂肪来源的间充质干细胞膝关节腔注射治疗骨关节炎的疗效影响因素分析
Jun Bum Park,Gi-Young Jang,Kye-Youl Cho et al.
Jun Bum Park et al.
Background: This study aims to assess the outcomes of intra-articular injection of adipose-derived mesenchymal stem cells (ADMSC) in osteoarthritis (OA) of knee joint up to 3-year follow-up and evaluate possible factors r...
Observational Study
Stem cells translational medicine. 2026 May 18;15(6):szag027. DOI:10.1093/stcltm/szag027 2026
Inhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism [0.03%]
肩袖撕裂肌肉退变的靶向治疗：整合生物靶向肌生成、抗纤维化和改善代谢的研究
Seok Won Chung,Jong Pil Yoon,Sung-Jin Park
Seok Won Chung
Rotator cuff (RC) tears are commonly associated with progressive muscle atrophy, fatty infiltration, and fibrosis, which often persist despite successful tendon repair and remain major barriers to functional recovery and structural integrit...
Extracellular vesicles from SB431542-conditioned human adipose-derived stem cells enhance in vitro and in vivo osteogenesis via a miR-20a-5p-BAMBI-BMP/canonical Wnt signaling axis [0.03%]
SB431542条件人脂肪源性干细胞外泌体通过miR-20a-5p-BAMBI-BMP/经典Wnt信号轴促进体内外源发生
Julika Huber,Michael T Longaker,Natalina Quarto
Julika Huber
Background: Critical-sized bone defects resulting from tumors, trauma, or surgery present a significant clinical challenge due to its poor self-regenerating capabilities and limited therapeutic options. Mesenchymal stem c...
A study on 18F-FDG PET/CT imaging assessment of the anti-aging efficacy of BMMSCs in the macaque brain [0.03%]
基于氟代脱氧葡萄糖正电子发射断层显像/计算机断层扫描的脑内间充质干细胞抗衰老效应评估研究
Pinghui Li,Yaxi Jiang,Xinghua Pan et al.
Pinghui Li et al.
Objective: Aging is a pressing global challenge requiring urgent solutions, and the anti-aging potential of mesenchymal stem cells (MSCs) has drawn global attention. This study treated aged macaques with bone marrow mesen...
Differentiation of cord blood-derived Innate Lymphoid Cells 1 into KIR+NKG2A- natural killer cells in a human stem cell niche [0.03%]
人干细胞生态位中脐血源性固有淋巴样细胞1向KIR+NKG2A-自然杀伤细胞分化
Sabrina B Bennstein,Julian Reiß,Sandra Weinhold et al.
Sabrina B Bennstein et al.
KIR+NKG2A- natural killer (NK) cells can detect and eliminate malignant and infected cells that have downregulated single HLA class I molecules to escape T cell recognition. So far, these KIRonly NK cells cannot be efficiently expanded in v...