Extracellular vesicles derived from differentiated granulosa-like cells restore the ovarian function of rats with premature ovarian insufficiency [0.03%]
分化颗粒细胞样细胞源性胞外囊泡可恢复卵巢早衰模型大鼠的卵巢功能
Cheng Zou,Zelan Yang,Yan Zou et al.
Cheng Zou et al.
Specifically differentiated cells exhibit greater therapeutic efficacy than mesenchymal stem cells (MSCs), and extracellular vesicles (EVs) present therapeutic benefits similar to those of parental cells and fewer safety issues. Ovarian gra...
Therapeutic potential of MSCs and their exosomes in hepatic Ischaemia-Reperfusion injury: a systematic review and meta-analysis of rodent studies [0.03%]
间充质干细胞及其外泌体在肝脏缺血再灌注损伤中治疗潜力的系统评价和Meta分析
Yanxi Mu,Weixiong Zhu,Wentao Ma et al.
Yanxi Mu et al.
Objective: This meta-analysis comprehensively evaluates the therapeutic efficacy and mechanisms of mesenchymal stem cells (MSCs) and their exosomes in rodent models of hepatic ischemia-reperfusion injury (HIRI), providing...
Cellular iron flux measurement by micromagnetic resonance relaxometry as a critical quality attribute of mesenchymal stromal cells [0.03%]
微磁共振弛豫度量细胞铁离子流量作为间充质基质细胞的关键质量属性
Yanmeng Yang,Meiqi Kang,Mengli Chen et al.
Yanmeng Yang et al.
Background: Clinical application of mesenchymal stromal cells (MSCs) for cartilage regeneration has been hampered by their poor retention of chondrogenic potential during in vitro culture, which has led to highly variable...
Clinical efficacy and safety of allogeneic adipose-derived stem cells ELIXCYTE in chronic kidney disease: a phase I/II study [0.03%]
自体脂肪来源干细胞治疗慢性肾病的安全性和有效性Ⅰ/Ⅱ期临床试验
Yi-Chun Lin,Yi-Pei Hung,Ya-Chung Tian et al.
Yi-Chun Lin et al.
Chronic kidney disease (CKD) poses a significant global health burden by reducing quality of life and increasing mortality. Current therapies remain inadequate in halting its progression, necessitating novel treatments to improve outcomes. ...
Human umbilical cord mesenchymal stem cells alleviate colon epithelial apoptosis in ulcerative colitis by activating inositol-requiring enzyme 1/X-box binding protein 1 signaling [0.03%]
人源脐带间充质干细胞通过激活inositol要求的酶1/X-框结合蛋白1信号通路缓解溃疡性结肠炎小鼠结肠上皮细胞凋亡
Taoran Zhao,Wenyi Hou,Mengwei Wang et al.
Taoran Zhao et al.
Background: Ulcerative colitis (UC), a chronic inflammatory gastrointestinal disease, is characterized by disrupted intestinal barrier integrity and unresolved endoplasmic reticulum (ER) stress, which drives epithelial ap...
The protection of mesenchymal stem cells in metabolic reprogramming and endothelial-mesenchymal transition in diabetic aortas [0.03%]
代谢重编程和内皮间充质转化对糖尿病主动脉间充质干细胞的保护作用
Mingying Ling,Jingxian He,Xu Jia et al.
Mingying Ling et al.
Vascular remodeling, a precursor to atherosclerosis and coronary heart disease, is associated with high morbidity and mortality in individuals with diabetes. The roles of endothelial-mesenchymal transition (EndMT) and human umbilical cord m...
Molecular time machines unleashed: small-molecule-driven reprogramming to reverse the senescence [0.03%]
分子时间机器：小分子驱动重编程以逆转衰老状态
Chunyin Tang,Zhen Zhang,Chunsong Yang et al.
Chunyin Tang et al.
Cellular reprogramming, a method of "resetting" the epigenetic clock by reversing the differentiation state of cells, has emerged as a promising approach to anti-aging, offering new strategies to slow down the aging process. Researchers con...
Therapeutic effect of amniotic membrane mesenchymal stem cell-derived exosome-rich conditioned medium in cerebral palsy model [0.03%]
人胎盘间充质干细胞外泌体治疗脑瘫动物模型的疗效研究
Eun-Jung Yoon,Jiwon Jeong,Yunseo Choi et al.
Eun-Jung Yoon et al.
Background: Cerebral palsy (CP), primarily caused by perinatal cerebral hypoxia and ischemia, is a devastating neurological disease in children characterized by motor, behavioral, and cognitive disorders. This study aimed...
Extracellular vesicles from mesenchymal stromal cells primed with synthetic toll-like receptor 4 agonists treat hematopoietic acute radiation syndrome [0.03%]
合成TLR4激动剂预处理的间充质基质细胞外泌体治疗造血急性辐射综合征
John A Kink,Matthew H Forsberg,Derek M Krismer et al.
John A Kink et al.
Whole-body exposure to ionizing radiation can lead to cellular DNA damage to bone marrow (BM), causing lethal hematopoietic acute radiation syndrome (H-ARS). Extracellular vesicles (EVs) from human BM-derived mesenchymal stromal cells were ...
Human induced pluripotent stem cell-derived neural stem/progenitor cell therapy for spinal cord injury: preclinical advances and translational perspectives [0.03%]
基于诱导多能干细胞的脊髓损伤治疗研究进展及转化应用前景
Ryo Ogaki,Narihito Nagoshi,Hideyuki Okano et al.
Ryo Ogaki et al.
Spinal cord injury (SCI) causes irreversible neurological damage and remains a major clinical challenge due to the lack of effective regenerative therapies. Human-induced pluripotent stem cells (hiPSCs) and their derivatives, hiPSC-derived ...