Corneal regenerative contribution of endogenous and grafted limbal-corneal cells in a mouse model of simple limbal-corneal epithelial transplantation [0.03%]
简单结膜-角膜上皮移植小鼠模型中外源和内源缘瓣细胞的角膜再生能力研究
Marcia F D Costa,Nicola Piazza,Erika Bonacci et al.
Marcia F D Costa et al.
Severe ocular damage, such as corneal alkali-injury, can compromise the limbal stem cell (LSC) niches, leading to LSC deficiency (LSCD) and resulting in significant vision impairment. Current insights into the wound healing process associat...
Extracellular vesicles conjugated with c(RGDyk) peptide targeting integrin αVβ3 repair optic nerve injury through YAP/TAZ and Smad2/3 signaling [0.03%]
靶向整合素αVβ3的c(RGDyk)肽修饰的细胞外囊泡通过YAP / TAZ和Smad2/3信号通路修复视神经损伤
Mira Park,Hyun Ah Shin,Hey Jin Lee et al.
Mira Park et al.
Extracellular vesicles (EVs) derived from mesenchymal stem cells have therapeutic potential for optic nerve injury. However, further investigations are needed to increase their efficacy. In this study, we tried to enhance targeting and reco...
MSC-small extracellular vesicles alleviated Th2-airway inflammation by regulating the metabolism of DCs in mice [0.03%]
小细胞外囊泡通过调节小鼠树突状细胞的代谢来缓解Th2型气道炎症
Long-Xin Huang,Lifen Wen,Tian Tian et al.
Long-Xin Huang et al.
Background: Allergic airway inflammation is one of the chronic inflammatory diseases and is generally dominated by T helper 2 cells (Th2). Dendritic cells (DCs) are essential to mounting the Th2-mediated airway inflammati...
Adamts4 coordinates the transcriptomic profile of primary rat costal chondrocytes [0.03%]
Adamts4调节大鼠肋软骨细胞转录谱型
Zhenxing Wei,Yijie Chen,Wanyi Kou et al.
Zhenxing Wei et al.
Chondrocytes play a pivotal role in cartilage tissue engineering. ADAMTS4 gene encodes aggrecanase-1, which is known to affect chondrocyte biology by regulating aggrecan degradation. However, the molecular mechanism by which ADAMTS4 regulat...
FGF2 alters the calvarial suture niche homeostasis shifting skeletal stem cell/progenitors toward an osteo-angiogenic coupling fate [0.03%]
FGF2通过重塑颅骨缝生态位平衡使骨骼干/祖细胞向成骨血管偶联命运分化
Natalina Quarto,Siddharth Menon,Jason L Guo et al.
Natalina Quarto et al.
Calvarial sutures, the major growth centers for skull morphogenesis, are currently regarded as "niches" for calvarial stem cells. Our previous study has identified a skeletal stem/progenitor cell population resident within the suture mesenc...
The harmonies played by miR-302/367 cluster in pluripotency, reprogramming, and rejuvenation [0.03%]
miR-302/367簇在多能性、重编程和返老还童中的作用
Melika Zamanian,Sharif Moradi,Hossein Baharvand
Melika Zamanian
The conserved, pluripotency-associated miR-302/367 cluster coordinates cell fate and aging via epigenetic, cell cycle, and signaling regulation. Highly expressed in pluripotent stem cells and silenced during differentiation, it promotes eff...
Yiping Fan,Si Tau Wong,Eyleen L K Goh et al.
Yiping Fan et al.
Brain injury describes a variety of injuries to the tissues and blood vessels in the head. It can be external such as in road accident or physical assaults or internal such as a stroke. Regardless, they are largely incurable with a long rou...
Adipose-derived stromal vascular fraction injection for radiation-induced bladder fibrosis: a first-in-human pilot study [0.03%]
人射线诱导的膀胱纤维化的脂肪源基质血管组分注射治疗：一项初步研究
Roger Klein,Nerone Douglas,Asim Ejaz et al.
Roger Klein et al.
Pelvic radiotherapy can lead to loss of bladder compliance, detrusor overactivity, and superficial vascular proliferation. Animal studies have demonstrated a reduction in radiation-induced inflammation and fibrosis following administration ...
Epicardial cell activation as a paradigm shift in cardiac repair and regeneration [0.03%]
冠状外膜细胞活化在心脏修复与再生中的范式转变
Roberto Vanni,Matteo Aubry,Mauro Rinaldi et al.
Roberto Vanni et al.
Cardiovascular diseases, particularly myocardial infarction, remain a leading cause of mortality globally, primarily due to the adult heart's limited regenerative capacity. Recent discoveries have highlighted the epicardium, a mesothelial l...
Heterogeneity and optimal study design between cell lines in induced pluripotent stem cell-based cardiac disease modeling [0.03%]
基于诱导多能干细胞的心脏疾病建模中的细胞系异质性和最佳研究设计
Renee G C Maas,Chris Denning,Joost P G Sluijter
Renee G C Maas
Human-induced pluripotent stem cell (hiPSC) technologies have provided access to in vitro models of inaccessible human cardiomyocytes (CMs), providing new insights into human disease mechanisms, therapy strategies, and cardiac toxicology. H...