Investigational New Drug-enabling studies to use genetically modified mesenchymal stromal cells in patients with critical limb ischemia [0.03%]
使用基因修饰的间充质基质细胞治疗重症肢体缺血患者的临床试验前研究
Amin Cressman,Bryan Le,David Morales et al.
Amin Cressman et al.
Mesenchymal stromal cells (MSCs) have been tested in multiple clinical trials to treat peripheral artery disease, especially the more severe form called critical limb ischemia. However, MSCs have often not met the expected efficacy endpoint...
Cell-based therapies in preclinical models of necrotizing enterocolitis: a systematic review and meta-analysis [0.03%]
坏死性小肠结肠炎细胞疗法的系统评价和荟萃分析
Camille Maltais-Bilodeau,Ewa Henckel,Marc-Olivier Deguise et al.
Camille Maltais-Bilodeau et al.
Necrotizing enterocolitis (NEC) remains an incurable gut complication of prematurity with significant morbidity and mortality. Cell therapies, including mesenchymal stromal cells (MSCs), may be a promising treatment given their anti-inflamm...
Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury [0.03%]
评估免疫调节策略以增强人类神经干细胞在脊髓损伤啮齿动物模型中存活和整合的评估
Zijian Lou,Alex Post,Narihito Nagoshi et al.
Zijian Lou et al.
Regenerative therapies are currently lacking for spinal cord injury (SCI). Neural progenitor cells (NPCs) have emerged as a promising therapeutic approach. To facilitate translation of NPCs into the clinic, studying human NPCs in rodent mod...
3' UTR-truncated HMGA2 promotes erythroblasts production from human embryonic stem cells [0.03%]
3'UTR截短的HMGA2促进人类胚胎干细胞向红系细胞分化
Tiantian Cui,Xiaoling Wang,Ruge Zang et al.
Tiantian Cui et al.
Cultured red blood cells represent an alternative resource for blood transfusions. However, important issues such as low yields and high costs remain. Recently, gene editing of hematopoietic stem cells has been conducted to induce erythroid...
Amniotic fluid stem cell extracellular vesicles as a novel fetal therapy for pulmonary hypoplasia: a review on mechanisms and translational potential [0.03%]
胎盘干细胞外泌体治疗肺发育不全的机制及转化应用前景的研究进展
Fabian Doktor,Lina Antounians,Rebeca Lopes Figueira et al.
Fabian Doktor et al.
Disruption of developmental processes affecting the fetal lung leads to pulmonary hypoplasia. Pulmonary hypoplasia results from several conditions including congenital diaphragmatic hernia (CDH) and oligohydramnios. Both entities have high ...
Current perspectives on the dynamic culture of mesenchymal stromal/stem cell spheroids [0.03%]
有关间充质基质/干细胞球体动态培养的最新研究进展
Yumi Ohori-Morita,Amal Ashry,Kunimichi Niibe et al.
Yumi Ohori-Morita et al.
Mesenchymal stromal/stem cells (MSCs) are promising candidates for regenerative medicine owing to their self-renewal properties, multilineage differentiation, immunomodulatory effects, and angiogenic potential. MSC spheroids fabricated by 3...
iPSC-derived retinal pigment epithelium: an in vitro platform to reproduce key cellular phenotypes and pathophysiology of retinal degenerative diseases [0.03%]
由诱导多能干细胞衍生的视网膜色素上皮：一个体外平台，可重现视网膜退行性疾病的细胞表型和病理生理学
Huirong Li,Ruchi Sharma,Kapil Bharti
Huirong Li
Retinal pigment epithelium (RPE) atrophy is a significant cause of human blindness worldwide, occurring in polygenic diseases such as age-related macular degeneration (AMD) and monogenic diseases such as Stargardt diseases (STGD1) and late-...
In vivo bioengineered tooth formation using decellularized tooth bud extracellular matrix scaffolds [0.03%]
利用去细胞牙蕾细胞外基质支架在体内进行生物工程化牙齿形成
Weibo Zhang,Pamela C Yelick
Weibo Zhang
The use of dental implants to replace lost or damaged teeth has become increasingly widespread due to their reported high survival and success rates. In reality, the long-term survival of dental implants remains a health concern, based on t...
Critical roles of extracellular vesicles in periodontal disease and regeneration [0.03%]
细胞外囊泡在牙周病和再生中的关键作用
Lin Jing,Hong-Yu Wang,Ning Zhang et al.
Lin Jing et al.
Extracellular vesicles (EVs) are evolutionarily conserved communication mediators that play key roles in the development of periodontal disease as well as in regeneration processes. This concise review first outlines the pathogenic mechanis...