METTL1-deficient mesenchymal stem cells protect against metabolic-associated fatty liver disease by increasing NAMPT secretion [0.03%]
METTL1缺陷性间充质干细胞通过增加NAMPT分泌对抗代谢相关脂肪肝病的作用
Jiang Du,Yuxuan Zhang,Chiheng Wang et al.
Jiang Du et al.
Background: Genetically modified mesenchymal stem cells (MSCs) have been shown to enhance their therapeutic properties, offering more effective treatment options for various diseases, including metabolic associated fatty ...
Dynamic immune reconstitution and clinical outcomes in different chimerism statuses of HLA-matched transplantation for severe aplastic anemia [0.03%]
人类白细胞抗原配型成功的重型再生障碍性贫血患者移植后免疫重建及不同嵌合体状态的临床转归
Ming-Hao Lin,Zheng-Li Xu,Ying-Jun Chang et al.
Ming-Hao Lin et al.
This retrospective study examines the clinical outcomes and immune reconstitution dynamics in patients with severe aplastic anemia (SAA) exhibiting mixed chimerism (MC) compared with those with full donor chimerism (FDC) following HLA-match...
Apoptotic periodontal ligament stem cells combined with developmental endothelial locus-1 counteract experimental periodontitis with type 2 diabetes mellitus [0.03%]
凋亡的牙周韧带干细胞联合血管发育定位点-1对抗2型糖尿病小鼠的实验性牙周病
Qian Ma,Houxuan Li,Xiaoyu Yang et al.
Qian Ma et al.
Stem cell therapy has been utilized in the treatment of periodontitis. Recent studies have demonstrated that treatment with apoptotic mesenchymal stem cells (MSCs) exhibits immunomodulatory effects comparable to those of living MSCs. Howeve...
Reproductive tissue-derived stromal cells rescue fertility by coupling follicular activation with endometrial remodeling [0.03%]
生殖组织源间充质干细胞通过连接卵泡激活和子宫内膜重塑来恢复生育力
Veronika Viktorija Borutinskaitė,Indrė Krastinaitė,Elvina Valatkaitė et al.
Veronika Viktorija Borutinskaitė et al.
Background: Mesenchymal stromal cells (MSCs) of various origins promote regeneration through paracrine signaling, immune modulation, and angiogenesis support. Premature ovarian failure (POF) is an excellent model to study...
Whole-genome CRISPR screening identifies genetic modifiers of stem cell-derived islet transplantation [0.03%]
基于全基因组的CRISPR筛选鉴定出影响干细胞来源的胰岛移植的遗传修饰因子
Marlie M Maestas,Kameron Bradley,Mira Shunkarova et al.
Marlie M Maestas et al.
Introduction: Genetically engineering human pluripotent stem cell (hPSC)-derived islets is a promising strategy for improving transplantation for diabetes cell therapy; however, genetic perturbations that modulate transpl...
The global regulatory landscape of stem cell medical aesthetics: challenges, comparisons, and pathways to coordination [0.03%]
全球干细胞医学美容监管格局：挑战、比较与协调路径
Yiding Xiao,Zirui Liao,Hailin Zhang et al.
Yiding Xiao et al.
This paper systematically examines the regulatory frameworks of major regulatory bodies-including the United States, the European Union, Japan, South Korea, and China-regarding the use of stem cells and their derivatives (such as conditione...
Autologous stem cell transplant for severe, progressive juvenile systemic sclerosis [0.03%]
自体干细胞移植治疗严重进行性幼年系统性硬化症
Shaikha Alqahtani,Fabiana Cacace,Andrea Bauchat et al.
Shaikha Alqahtani et al.
Juvenile systemic sclerosis (jSSc) is a rare, chronic, autoimmune disease in children/adolescents and is associated with significant morbidity, skin thickening/hardening (scleroderma), organ toxicity and sub-optimal therapeutic options. In ...
Alveolar ridge preservation with lyophilized microspheres of human dental pulp stem cells following 3D dynamic osteogenic induction [0.03%]
三维动态成骨诱导的人牙髓干细胞冻干微球用于牙槽嵴保存的效果研究
Yangyang Li,Jethro Zih-Shuo Wang,Zihan Yang et al.
Yangyang Li et al.
The clinical use of bone graft materials for alveolar ridge preservation following tooth extraction has become a standard procedure to facilitate subsequent implant restoration and prosthetic rehabilitation. However, the therapeutic efficac...
Towards evolutionary guided precision medicine of acute myeloid leukemia and Fanconi anemia associated bone marrow failure [0.03%]
向导进化精准医学治疗急性髓系白血病和范可尼贫血相关的骨髓衰竭
Robert A Beckman,Pamela S Becker,Julia Gallini et al.
Robert A Beckman et al.
Carcinogenesis and acquisition of multidrug resistance within established cancers are both multistep evolutionary processes in which stem cells play a role. This perspective will briefly review two corresponding theoretical constructs under...
Senescence profiling and biomarker identification in cell product based on adipose tissue-derived mesenchymal stromal cells [0.03%]
基于脂肪组织来源的间充质基质细胞的细胞产品的衰老表征及生物标志物鉴定
Ellen Mønsted Johansen,Cecilie Hoeeg,Rebekka Harary Søndergaard et al.
Ellen Mønsted Johansen et al.
Background/aim: Adipose tissue-derived mesenchymal stromal cells (ASC) are used in advanced therapy medicinal products due to their regenerative and immunomodulatory properties. Increasing the number of dosages derived fr...