A study on 18F-FDG PET/CT imaging assessment of the anti-aging efficacy of BMMSCs in the macaque brain [0.03%]
基于氟代脱氧葡萄糖正电子发射断层显像/计算机断层扫描的脑内间充质干细胞抗衰老效应评估研究
Pinghui Li,Yaxi Jiang,Xinghua Pan et al.
Pinghui Li et al.
Objective: Aging is a pressing global challenge requiring urgent solutions, and the anti-aging potential of mesenchymal stem cells (MSCs) has drawn global attention. This study treated aged macaques with bone marrow mesen...
Differentiation of cord blood-derived Innate Lymphoid Cells 1 into KIR+NKG2A- natural killer cells in a human stem cell niche [0.03%]
人干细胞生态位中脐血源性固有淋巴样细胞1向KIR+NKG2A-自然杀伤细胞分化
Sabrina B Bennstein,Julian Reiß,Sandra Weinhold et al.
Sabrina B Bennstein et al.
KIR+NKG2A- natural killer (NK) cells can detect and eliminate malignant and infected cells that have downregulated single HLA class I molecules to escape T cell recognition. So far, these KIRonly NK cells cannot be efficiently expanded in v...
Intra-articular allogeneic adipose-derived mesenchymal stromal cell injections for stage III knee osteoarthritis: a double-blind placebo-controlled trial with 60-month follow-up [0.03%]
同种异体脂肪来源的间充质干细胞关节腔注射治疗膝骨关节炎的双盲安慰剂对照试验（六年随访）
Hanan Jafar,Osama Samara,Diana Shahin et al.
Hanan Jafar et al.
Knee osteoarthritis (KOA) is a progressive degenerative joint disease with limited treatment options that effectively modify disease progression. This study evaluates the safety and efficacy of allogeneic adipose-derived mesenchymal stromal...
Randomized Controlled Trial
Stem cells translational medicine. 2026 Apr 27;15(5):szag018. DOI:10.1093/stcltm/szag018 2026
Extracellular vesicles produced by a large-scale protocol are therapeutically effective in preclinical model of Parkinson's disease [0.03%]
大规模制备的细胞外囊泡在帕金森病临床上具有治疗效果
Agnė Pociūtė,Virginijus Tunaitis,Arūnas Žebrauskas et al.
Agnė Pociūtė et al.
Background: Therapeutic applications require large amounts of extracellular vesicles (EVs) that cannot be obtained by standard laboratory protocols. Since culturing parameters and isolation methods can significantly affec...
Discovery and validation of islet regenerative proteins secreted by human multipotent stromal cells [0.03%]
人类多能基质细胞分泌的促进胰岛再生蛋白的发现和验证
Xin Y Xie,Nouran N Al-Banaa,Yina Tian et al.
Xin Y Xie et al.
Introduction: Diabetes affects >500 million people worldwide. Despite insulin therapy, most patients develop devastating complications, emphasizing the need for curative strategies. Human multipotent stromal/stem cells (M...
Moderate neuroprotection of combination cell therapy in fetal growth restricted newborns at postnatal day 10 [0.03%]
联合细胞治疗对产后第10天生长受限新生儿的中度神经保护作用
Kirat K Chand,Kate Beecher,Rachel Nano et al.
Kirat K Chand et al.
Infants with fetal growth restriction (FGR) are at increased risk of adverse neurodevelopmental conditions, including motor, learning, and behavioral deficits. There are currently no treatments to protect the FGR newborn from lifelong neuro...
Effects of increasing intranuclear calcium levels via MCU inhibition on mouse and human PSC-derived cardiomyocyte differentiation and maturation [0.03%]
通过MCU抑制增加核内钙离子水平对小鼠和人类多能干细胞来源的心肌细胞分化及成熟的影响
Hyun Ju Seo,Ju-Young Kim,Hyun-Jai Cho et al.
Hyun Ju Seo et al.
Background Cardiovascular diseases remain the leading cause of death worldwide, accounting for approximately 19.41 million deaths annually. Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great promise for diseas...
A selection model for umbilical cord blood units with high isolation yield of total nucleated and CD34+ cells [0.03%]
一种选择脐带血单位的模型以获得较高总量核细胞和CD34+细胞产率
Vuong M Pham,Hung V Nguyen,Qui T Dang et al.
Vuong M Pham et al.
Background: Cord blood is an important hematopoietic stem cell source for treating over 80 FDA-approved diseases, driving demand for HSC-containing-umbilical cord blood (UCB) unit cryopreservation for future use. Total nu...
Efficient and robust generation of functional hematopoietic cells from human pluripotent stem cells in albumin-free conditions [0.03%]
无白蛋白条件下高效分化人多能干细胞产生造血功能细胞
Byung Woo Kim,Linyi Zhang,Mo Liu et al.
Byung Woo Kim et al.
Generation of human hematopoietic stem and progenitor cells (HSPCs) from pluripotent stem cells (PSCs) holds significant promise in disease modeling, drug screening, and the development of cell and gene therapies for various hematologic and...
Bone tissue regeneration: role of osteocyte mechanosensing and mechanotransduction [0.03%]
骨组织再生：成骨细胞力学感知与力信号转导的作用
Hadi Seddiqi,Jenneke Klein-Nulend,Jianfeng Jin
Hadi Seddiqi
Critical-sized bone defects caused by trauma, tumor resection, injury, and/or surgical intervention are posing significant clinical challenges. Bone tissue regeneration is crucial for restoring critical-sized bone defects. Central to the bo...